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Conventional Knockout Mice

A conventional knockout is a mouse model in which a targeted gene or genetic region has been functionally or completely eliminated. This process is done by inserting a selection cassette or a reporter gene such as GFP or lacZ into the locus of the gene. The resulting deletion yields a mouse model lacking the function of those targeted genes.

Conventional Knockout Mice Diagram 

 

inGenious Targeting Laboratory
iTL delivers genetically modified mouse model services: conventional knockout mice, conditional knockout mice (KO mouse models), knockin mice
(reporter genes, humanizations, cDNA)
, transgenics (targeted transgenic mouse models) Copyright 2010 inGenious Targeting Laboratory, Inc.