clients across the globe achieve gene targeting and custom mouse model success with iTL
What You Need
F.A.S.T.™: One Vector, Five Mouse Lines.
Do you need a knockout?
Do you need to rescue gene expression?
Do you need to over-express your gene?
Do you need to knockdown your gene?
If you answered all or some of these questions with yes, then the FAST System is the right tool for you!
Based on the inducible tetracycline operator, iTL’s exclusive F.A.S.T.™ (Flexible Accelerated STOP TetO-knockin) technology will boost your research through unparalleled flexibility. One targeting event establishes the potential to generate up to five mouse lines for the same locus, just using mating.
Not satisfied just with the parental line, a constitutive, global knockout of your gene? Mate the parental line with a Cre model to generate a tissue-specific rescue line. Choose a tetracycline transactivator (tTA) line to produce an ectopic gene expression model, or a tissue-specific overexpression model. Or use a tetracycline trans-silencer (tTS) line to generate a tissue-specific conditional knockout/knockdown.
Join the investigators who are already exploring the versatility of multiple gain- and loss-of-function mouse lines, produced using this exciting and cost-saving approach. Get your mouse the F.A.S.T.™ way!
For more information and pricing, please contact us