Knock-out Mouse Models

Knock-out mice have been widely used across the study of gene function, drug and therapeutic development and disease research. Mice remain the most efficient and easily genetically manipulated animal research model. Their genetic similarity to humans allows valuable advancements in human health research.

iTL’s commitment to developing and producing gene targeted mouse models as effective research tools began with conventional mouse knock-outs. As technology and our customers research has progressed, iTL has expanded our core competencies to more challenging and intricate variations of mouse knock-outs and knock-ins to continue to bring powerful research tools to our customers. Below are some of iTL’s knock-out specializations:

Conventional knock-out. The targeted gene is functionally eliminated Conditional knock-out. A site-specific DNA recombination for gene deletion in targeted tissues Knock-out with reporter gene. The introduction of a reporter gene marker to monitor target gene expression