Knockout Mouse Models

Knockout mice have been widely used across the study of gene function, drug and therapeutic development and disease research. Mice remain the most efficient and easily genetically manipulated animal research model. Their genetic similarity to humans allows valuable advancements in human health research.

iTL’s commitment to developing and producing gene targeted mouse models as effective research tools began with conventional mouse knockouts. As technology and our clients research has progressed, iTL has expanded our core competencies to more challenging and intricate variations of mouse knockouts and knockins to continue to bring powerful research tools to our clients. Below are some of iTL's knockout specializations:

Conventional knockout. The targeted gene is functionally eliminated

Conditional knockout. A site-specific DNA recombination for gene deletion in targeted tissues

Knockout with reporter gene. The introduction of a reporter gene marker to monitor target gene expression