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iTL ADVANTAGES |
Globally Experienced |
clients across the globe achieve gene targeting and custom mouse model success with iTL |
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We Help You
Stay Ahead of the Curve |
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iTL released a study of the performance of their 'iTLb' BALB/c mouse embryonic stem (ES) cell line for the creation of gene targeted, transgenic mice. As the whitepaper presents, the iTLb cell line overcomes previous BALB/c limitations with high rates of homologous recombination and germline transmission.
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| News |
 Industry News
-- Cell phone radiation may fight Alzheimer's... in mice
The possibility that cellular phones have an impact on human health has generally been viewed in terms of the potential to do harm, primarily by inducing or promoting the growth of cancer. But a study that will be published by the Journal of Alzheimer's Disease may turn that all on its head.
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-- An autoimmune-mediated strategy for prophylactic breast cancer vaccination
Immunologically targeting α-lactalbumin, a breast-specific protein highly expressed in breast carcinomas but absent from nonlactating mammary cells, provides protection against breast cancer in mice. This strategy may protect women against breast cancer in their post–child-bearing years, when lactation is readily avoidable and risk for developing breast cancer is high.
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-- UCSF transgenic mouse mimics Parkinson’s earliest symptoms
UCSF researchers have created the first transgenic mouse to display the earliest signs of Parkinson’s disease using the genetic mutation that is known to accompany human forms of the disease.
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-- Novel Model of Depression from Social Defeat Shows Restorative Power of Exercise
In a study in a mouse model that mimics the contribution of social stress to human depression, an environment that promotes exercise and exploration alleviated depressive behavior in the mice. The beneficial effect of activity depended on the growth of new neurons in the adult brain.
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 iTL News
-- New BALB/c Cell Line Whitepaper Released
iTL released a study of the performance of their 'iTLb' BALB/c mouse embryonic stem (ES) cell line for the creation of gene targeted, transgenic mice. As the whitepaper presents, the iTLb cell line overcomes previous BALB/c limitations with high rates of homologous recombination and germline transmission.
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Client Publications
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-- Tgif1 and Tgif2 regulate Nodal signaling and are
required for gastrulation
Project Type: 129SvEv Reporter Knockin
-- Impaired Intestinal Vitamin B1 (Thiamin) Uptake in
Thiamin Transporter-2–Deficient Mice
Project Type: 129SvEv Conventional Knockout
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-- ErbB activity links the glucagon-like peptide-2 receptor to refeeding-
induced adaptation in the murine small bowel
Project Type: C57BL/6 Conventional Knockout
-- Role of CaMKIIδ phosphorylation of the cardiac ryanodine receptor in
the force frequency relationship and heart failure
Project Type: Hybrid Point Mutation Knockin
-- Conditional deletion of Abca3 in alveolar type II cells alters surfactant
homeostasis in newborn and adult mice
Project Type: 129SvEv Conditional Knockout
-- Cyclic Expression of Lhx2 Regulates Hair Formation
Project Type: Hybrid Conditional Knockout
-- Abnormalities of cell packing density and dendritic complexity in
the MeCP2 A140V mouse model of Rett syndrome/X-linked mental
retardation
Project Type: 129 SvEv Mutation
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| Events |
November 13-17, San Diego, California, USA
iTL will attend the Neuroscience 2010. Come speak with us at our booth and learn about a new BALB/c line
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| Resources |
-- Software for researchers
As research and technology has advanced in the field of genetics and animal models, there has been an increase in the need for time and cost saving software. Below are a few options our staff and clients have found useful
- JCMS : Jackson Laboratory Colony Management Software
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Client Quote of the Quarter
"We made our own global knockout mouse,...it cost me 2 years and 5 times more money. iTL did exactly what they said they would...I have argued with reviewers and program administrators that having these mice generated by iTL was the efficient way to go...you have proven me right"
| Sponsorship
iTL proudly sponsors the TransGenic-List and ISTT
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| ©Copyright 2011All Rights Reserved. Ingenious Targeting Laboratory, Inc |
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