inGenious Targeting Laboratory
inGenious Targeting Laboratory
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Publications

The ability to publish your results in globally respected peer reviewed journals is critical to your success. Since our first client published their research (Science, 2001), iTL clients have published over 100 articles in the world’s highest profile publications using their iTL custom mouse models.

Our clients have published numerous times in journals such as Nature, Science, Cell, PNAS, and the Journal of Biological Chemistry.  Leading the scientific community by pairing your novel ideas with our seasoned gene targeting experience is what fuels iTL’s and our clients’ passion to work together.

 


Below are just a few of the recent publications resulting from the accomplishments of iTL clients using their iTL custom gene targeted mouse models.

Publications by year


2011 publications

Modeling the Human MTM1p.R69C Mutation in Murine Mtm1 Results in Exon 4 Skipping and a Less Severe Myotubular Myopathy Phenotype (2011)
Pierson CR, Dulin-Smith AN, Durban AN, Marshall ML, Marshall JT, Snyder AD, Naiyer N, Gladman JT,  Chandler DS, Lawlor MW, Buj-Bello A, Dowling JJ, and Beggs AH; Human Mol. Genetics;First published online: November 7, 2011 doi: 10.1093

Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice (2011)
Yiannikouris F, Karounos M, Charnigo R,  English VL, Rateri DL, Daugherty A and Cassis LA; American Journal of Physiology Regulatory, Integrative and Comparative Physiology; Published online before print November 2011, doi: 10.​1152

Leucine Zipper Putative Tumor Suppressor 2, LZTS2, Regulates Kidney Development (2011)
Peng Y , Clark C, Luong R, Tu WH, Lee J, Johnson DT, Das A, Carroll TJ, Sun Z; Journal of Biological Chemistry; published online first September 26, 2011

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways (2011)
Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG,  Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S and Ting JPY; Immunity; 34(6); 854-865

SRY-Box Containing Gene 17 Regulates the Wnt/β-Catenin Signaling Pathway in Oligodendrocyte Progenitor Cells (2011)
Chew LJ, Shen W, Ming X, Senatorov Jr VV, Chen HL, Cheng Y, Hong E, Knoblach K, and Gallo V; Journal of Neuriscience; 31(39):13921-13935

Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways (2011)
Kazuhito Tsuboi, Yasuo Okamoto, Natsuki Ikematsu, Manami Inoue, Yoshibumi Shimizu, Toru Uyama, Jun Wang, Dale G. Deutsch, Matthew P. Burns, Nadine M. Ulloa, Akira Tokumura and Natsuo UedaBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids; 1811 (10); 565-577

Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis (2011)
Xiaodong Ma, Munish Kumar, Saibyasachi N. Choudhury, Lindsey E. Becker Buscaglia, Juanita R. Barker, Keerthy Kanakamedala, Mo-Fang Liu, and Yong Li; PNAS; 108 (25) 10144-10149

Mouse transmembrane BAX inhibitor Motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system (2011)
Joseph A. Nielsen, Meredith A. Chambers, Elena Romm, Laurel Yong-Hwa Lee, Jo Ann Berndt and Lynn D. Hudson; Molecular and Cellular Biology; Online first DOI: 10.1007/s11010-011-0877-3

Characterization of a Sphingosine 1-phosphate Receptor Antagonist Prodrug   (2011)
Perry C. Kennedy, Ran Zhu, Tao Huang, Jose L. Tomsig, Thomas P. Mathews, Marion David, Olivier Peyruchaud, Timothy L. Macdonald, Kevin R. Lynch; Journal of Phamacology and Experimental Therapeutics; Online first DOI: 10.1124/jpet.111.181552

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling (2011)
Andrew T. Templin, Bernhard Maier, Yurika Nishiki, Sarah A. Tersey and Raghavendra G. Mirmira; Cell Cycle; 10 (7); 1043-1049

Hippocampal phenotypes in kalirin-deficient mice (2011)
Zhong Xie, Michael E. Cahill, Jelena Radulovic, Jing Wang, Susan L. Campbell, Courtney A. Miller, J. David Sweatt and Peter Penzes; Molecular and Cellular Neuroscience; 46 (1); 45-54

Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine  in mice (2011)
Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch DG, Ueda N and Hansen HS; Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids vol1811 (9), 2011, 508-512

G-Protein -Complex Is Crucial for Efficient Signal Amplification in Vision (2011)
Kolesnikov AV, Rikimaru L, Hennig AK, Lukasiewicz PD, Fliesler SJ, Govardovskii VI, Kefalov VJ, and Kisselev OG; The Journal of Neuroscience, 1 June 2011, 31(22): 8067-8077

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice (2011)
Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenburg A, Wei Y, Vu TH; The Journal of Clinical Invest. 2011;121(7):2855–2862.

The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice; (2011)
Bacchelli C, Buckland KF, Buckridge S, Salzer U, Schneider P, Thrasher AJ, Gaspar HB; J ALLERGY CLIN IMMUNOL, Vol 127 (5) May 2011, 1253-1273.

Group X Secretory Phospholipase A2 Enhances TLR4 Signaling in Macrophages (2011)
Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR; The Journal of Immunology May 27, 2011 1003552

Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder (2011)
Zubenko GS, Hughes III HB. 2011. Am J Med Genet Part B.

Deletion of the Distal C Terminus of CaV1.2 Channels Leads to Loss of β-Adrenergic Regulation and Heart Failure in Vivo; (2011)
Fu Y, Westenbroek RE, Yu FH, Clark, JP III, Marshall MR, Scheuer T, Catterall WA; The Journal of Biological Chemistry, April 2011, 286, 12617-12626.

A CTRP5 gene S163R mutation knock-in mouse model for late-onset retinal degeneration (2011)
Chavali VR, Khan NW, Cukras CA, Bartsch DU, Jablonski MM, Ayyagari R;
Hum Mol Genet. 2011 May 15;20(10):2000-14.

ATP binding cassette G1-dependent cholesterol efflux during inflammation; (2011)
deBeer MC, Ji A, Jahangiri A, Vaughan AM, deBeer FC, van der Westhuyzen DR, Webb NR;
The Journal of Lipid Research, Feb 2011 52, 345-353.

Dynamic spatiotemporal gene expression in embryonic mouse thalamus; (2011)
Suzuki-Hirano A, Ogawa M, Kataoka A, Yoshida AC, Itoh D, Ueno M, Blackshaw S, Shimogori T; The Journal of Comparative Neurology, Feb 2011;
vol 519 (3), 528-543

Selenoprotein K Knockout Mice Exhibit Deficient Calcium Flux in Immune Cells and Impaired Immune Responses (2011)
Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto A.S., Hoffman P.R.;
Journal of Immunology 2011 vol. 186 no. 4, 2127-2137

Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor–/– Mice (2011)
Debra L. Rateri, Jessica J. Moorleghen, Anju Balakrishnan, A. Phillip Owens, III, Deborah A. Howatt, Venkateswaran Subramanian, Aruna Poduri, Richard Charnigo, Lisa A. Cassis Alan Daugherty;
Circulation Research 2011 Print ISSN: 0009-7330. Online

A transgenic mouse for in vivo detection of endogenous labeled mRNA (2011)
Timothée Lionnet,Kevin Czaplinski,Xavier Darzacq,Yaron Shav-Tal,Amber L Wells,Jeffrey A Chao,Hye Yoon Park,Valeria de Turris,Melissa Lopez-Jones& Robert H Singer;
Nature Methods 2011 Vol 8, 165-170  

Na,K-ATPase α4 isoform is essential for sperm fertility (2011)
Tamara Jimenez,Jeffrey P. McDermott,Gladis Sánchez, and Gustavo Blanco;
PNAS Jan qq, 2011, vol. 108 no.2 644-649

2010 publications

Functional muscle analysis of the Tcap knockout mouse (2010)
C.D. Markert, M.P. Meaney, K.A. Voelker, R.W. Grange, H.W. Dalley, J.K. Cann, M. Ahmed, B. Bishwokarma, S.J. Walker, S.X. Yu, M. Brown, M.W.Lawlor, A.H. Beggs and M.K. Childers;
Human Molecular Genetics, 2010, Vol. 19, No. 11 2268–2283

Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis (2010)
Eckhardt ER, Witta J, Zhong J, Arsenescu R, Arsenescu V, Wang Y, Ghoshal S, de Beer MC, de Beer FC, de Villiers WJ.
BMC Gastroenterol. 2010 Nov 10;10:133.

Impact of serum amyloid A on high density lipoprotein composition and levels (2010)
Maria C. de Beer1, Nancy R. Webb*,. Joanne M. Wroblewski*,Victoria P. Noffsinger, Debra L. Rateri* Ailing Ji*Deneys R. van der Westhuyzen and Frederick C. de Beer*
The Journal of Lipid Research, 51,; November 2010, 3117-3125

Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation (2010)
Garilyn M Jentarra, Shannon L Olfers, Stephen G Rice, Nishit Srivastava, Gregg E Homanics, Mary Blue, SakkuBai Naidu, Vinodh Narayanan
Neuroscience 2010, 11:19

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy (2010)
Yuko Fukataa, Kathryn L. Loveroc, Tsuyoshi Iwanagaa, Atsushi Watanabed, Norihiko Yokoia, Katsuhiko Tabuchie,Ryuichi Shigemotoe, Roger A. Nicollc, and Masaki Fukataa
PNAS. 2010 Feb 23;107(8):3799-804.

Cyclic Expression of Lhx2 Regulates Hair Formation (2010)
Gunilla To¨ rnqvist., Anna Sandberg., Anna-Carin Ha¨gglund, Leif Carlsson
Plos Genetics.April 2010.Volume 6.Issue 4.e1000904

Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice (2010)
Valérie Besnard, Yohei Matsuzaki, Jean Clark, Yan Xu, Susan E. Wert, Machiko Ikegami,Mildred T. Stahlman, Timothy E. Weaver, Alan N. Hunt, Anthony D. Postle, and Jeffrey A. Whitsett
American Journal of Physiology, Lung Cell Mol Physiol 298: L646–L659, 2010.

Role of CaMKIIδ phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure (2010)
Alexander Kushnir, Jian Shan, Matthew J. Betzenhauser, Steven Reiken, and Andrew R. Marks
PNAS | June 1, 2010 | vol. 107 | no. 22

Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation (2010)
Shannon E. Powers, Kenichiro Taniguchi, Weiwei Yen, Tiffany A. Melhuish, Jun Shen, Christopher A. Walsh, Ann E. Sutherland and David Wotton
Development 137, 249-259 (2010) doi:10.1242/dev.040782

Impaired Intestinal Vitamin B1 (Thiamin) Uptake in Thiamin Transporter-2–Deficient Mice (2010)
JACK C. REIDLING, NILS LAMBRECHT, MOHAMMAD KASSIR and HAMID M. SAID
GASTROENTEROLOGY 2010;138:1802–1809

ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel (2010)
Bahrami, J., Yusta, B., Drucker, D.J.
Gastroenterology (2009), doi: 10.1053/j.gastro.2010.03.006

Modulation of Angiotensin II–Mediated Cardiac Remodeling by the MEF2A Target Gene Xirp2 (2010)
Sarah A. McCalmon, Danielle M. Desjardins, Saad Ahmad, Katharine S. Davidoff,Christine M. Snyder, Kaori Sato, Koji Ohashi, Ondra M. Kielbasa, Matthen Mathew,Elizabeth P. Ewen, Kenneth Walsh, Haralambos Gavras, Francisco J. Naya
Circ. Res. 2010;106;952-960

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo (2010)
David R. Gibb, Mohey El Shikh, Dae-Joong Kang, Warren J. Rowe, Rania El Sayed, Joanna Cichy, Hideo Yagita, John G. Tew, Peter J. Dempsey, Howard C. Crawford, and Daniel H. Conrad
The Journal of Experimental Medicine, Vol. 207, No. 3, 623-635. February 15, 2010

ZFP191 is required by oligodendrocytes for CNS myelination (2010)
Howng SY, Avila RL, Emery B, Traka M, Lin W, Watkins T, Cook S, Bronson R, Davisson M, Barres BA, Popko B.
Genes Dev. 2010 Feb 1;24(3):301-11. Epub 2010 Jan 15

Human TUBB3 Mutations Perturb Microtubule Dynamics, Kinesin Interactions, and Axon Guidance (2010)
Max A. Tischfield, Hagit N. Baris, Chen Wu, Guenther Rudolph, Lionel Van Maldergem, Wei He, Wai-Man Chan, Caroline Andrews, Joseph L. Demer, Richard L. Robertson, David A. Mackey, Jonathan B. Ruddle, Thomas D. Bird, Irene Gottlob, Christina Pieh, Elias I. Traboulsi, Scott L. Pomeroy, David G. Hunter, Janet S. Soul, Anna Newlin, Louise J. Sabol, Edward J. Doherty, Clara E. de Uzca´ tegui, Nicolas de Uzca´ tegui, Mary Louise Z. Collins, Emin C. Sener, Bettina Wabbels, Heide Hellebrand, Thomas Meitinger, Teresa de Berardinis, Adriano Magli, Costantino Schiavi, Marco Pastore-Trossello, Feray Koc, Agnes M. Wong, Alex V. Levin, Michael T. Geraghty, Maria Descartes, Maree Flaherty, Robyn V. Jamieson, H.U. Møller, Ingo Meuthen, David F. Callen, Janet Kerwin, Susan Lindsay, Alfons Meindl, Mohan L. Gupta, Jr., David Pellman, and Elizabeth C. Engle
Cell. Volume 140, Issue 1, 8 January 2010, Pages 74-87

2009 publications (Click "+" to expand)

2008 publications (Click "+" to expand)