Publications

We are one of the most highly experienced and published mouse gene targeting companies in the industry. All of the publications listed on our website are specifically for gene targeted mouse models that we have created in-house for our research clients since 1998.

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2016

NLRP2 controls age-associated maternal fertility. Anna A. Kuchmiy, Jinke D’Hont, Tino Hochepied, Mohamed Lamkanfi, J Exp Med. 2016 Nov 23. pii: jem.20160900

 

Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis Thomas Marichal, Nicolas Gaudenzio, Sophie El Abbas, Riccardo Sibilano, Oliwia Zurek, Philipp Starkl, Laurent L. Reber, Dimitri Pirottin, Jinah Kim, Pierre Chambon, Axel Roers, Nadine Antoine, Yuko Kawakami, Toshiaki Kawakami, Fabrice Bureau, See-Ying Tam, Mindy Tsai, and Stephen J. Galli1, J Clin Invest. doi:10.1172/JCI86359.

 

Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to long-term potentiation and spatial learning Evanthia Nanou, Todd Scheuer, and William A. Catterall PNAS 2016 113 (46) 13209-13214

 

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate Divya Jayaraman, Andrew Kodani, Dilenny M. Gonzalez, Joseph D. Mancias, Ganeshwaran H. Mochida, Cristiana Vagnoni, Jeffrey Johnson, Nevan Krogan, J. Wade Harper, Jeremy F. Reiter, Timothy W. Yu, Byoung-il Bae, Christopher A. Walsh; DOI: http://dx.doi.org/10.1016/j.neuron.2016.09.056

 

C-terminal Deletion of the HDL Receptor Reduces Receptor Levels in Liver and Steroidogenic Tissues, Induces Hypercholesterolemia and Causes Fatal Heart Disease. Rinku Pal, Qingen Ke, German A Pihan, Ayce Yesilaltay, Marsha L Penman, Li Wang, Chandramohan Chitraju, Peter M. Kang, Monty Krieger, Olivier Kocher, Am J Physiol Heart Circ Physiol. 2016 Sep 30:ajpheart.00463.2016. doi: 10.1152/ajpheart.00463.2016.

 

T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice. Xiao-Fei Wang, Elisabeth Barbier, Yi-Ting Chiu, Yi He, Jia Zhan, Guo-Hua Bi, Hai-Ying Zhang, Bo Feng, Lee-Yuan Liu-Chen, Jia Bei Wang and Zheng-Xiong Xi J Neurosci. 2016 Oct 5;36(40):10392-10403.

 

MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure Through Enhanced Rap1 Activation in Podocytes. Jie Ni1, Sujin Bao2, Ruth I. Johnson, Bingbing Zhu, Jianhua Li, Justin Vadaparampil, Christopher M. Smith, Kirk N. Campbell, Florian Grahammer, Tobias B. Huber, John C. He, Vivette D. D’Agati, Andrew Chan and Lewis Kaufman, J Biol Chem. 2016 Oct 5. pii: jbc.M116.745026

 

Long non-coding RNAs regulate effects of β-crystallin B2 on mouse ovary development. Qian Gao, Hanxiao Ren, Mingkun Chen, Ziguang Niu, Haibo Tao, Yin Jia, Jianrong Zhang, Wenjie Li, Mol Med Rep. 2016 Nov;14(5):4223-4231. doi: 10.3892/mmr.2016.5761. Epub 2016 Sep 22.

 

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Wendy Béguelin, Matt Teater, Micah D. Gearhart, María Teresa Calvo Fernández, Rebecca L. Goldstein, Mariano G. Cárdenas, Katerina Hatzi, Monica Rosen, Hao Shen, Connie M. Corcoran, Michelle Y. Hamline, Randy D. Gascoyne, Ross L. Levine, Omar Abdel-Wahab, Jonathan D. Licht, Rita Shaknovich, Olivier Elemento, Vivian J. Bardwell, Ari M. Melnick. Cancer Cell 2016 Aug 8;30(2):197-213. doi: 10.1016/j.ccell.2016.07.006.

 

Deficiency of SPATA46, a Novel Nuclear Membrane Protein, Causes Subfertility in Male Mice. Jianbo Chen, Yanli Gu, Zeng Zhang, Wenzhong Zheng, Lihua Yang, Weiren Huang, Shouren Lin, Yuchi Li, Huan Guo, Manling Luo, Qian Ma, Zhimao Jiang, Aifa Tang, and Yaoting Gui. Biol Reprod. 2016 Aug 3. pii: biolreprod.116.140996. [Epub ahead of print]

 

Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. Hsin-Yuan Cheng, Dalia E. Gaddis, Runpei Wu, Chantel McSkimming, LaTeira D. Haynes, Angela M. Taylor, Coleen A. McNamara, Mary Sorci-Thomas, and Catherine C. Hedrick. J Clin Invest. 2016 Aug 2. pii: 83136. doi: 10.1172/JCI83136. [Epub ahead of print]

 

Hierarchy within the mammary STAT5-driven Wap super-enhancer. Ha Youn Shin, Michaela Willi, Kyung Hyun Yoo, Xianke Zeng, Chaochen Wang, Gil Metser, & Lothar Hennighausen; Nat Genet. 2016 Aug;48(8):904-11. doi: 10.1038/ng.3606. Epub 2016 Jul 4.

 

The K153Del PRPH2 mutation differentially impacts photoreceptor structure and function. Dibyendu Chakraborty, Shannon M. Conley, Rahel Zulliger, and Muna I. Naash, Hum Mol Genet. 2016 Jun 29. pii: ddw193

 

Gene Therapy Corrects Mitochondrial Dysfunction in Hematopoietic Progenitor Cells and Fibroblasts from Coq9R239X Mice. Eliana Barriocanal-Casado, Cristina Cueto-Ureña, Karim Benabdellah, Alejandra Gutiérrez-Guerrero, Marién Cobo, Agustín Hidalgo-Gutiérrez, Juan José Rodríguez-Sevilla, Francisco Martín, Luis C. López; PLoS One. 2016 Jun 24;11(6):e0158344. doi: 10.1371/journal.pone.0158344. eCollection 2016.

 

CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis. Christine Caron, Jonathan DeGeer, Patrick Fournier, Philippe M. Duquette, Vilayphone Luangrath, Hidetaka Ishii, Fereshteh Karimzadeh, Nathalie Lamarche-Vane, and Isabelle Royal, Sci Rep. 2016 Jun 7;6:27485. doi: 10.1038/srep27485.

 

Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. Xudong Wu , Artur A. Indzhykulian , Paul D. Niksch, Roxanna M. Webber, Miguel Garcia-Gonzalez, Terry Watnick, Jing Zhou, Melissa A. Vollrath, David P. Corey PLoS ONE 11(5): e0155577. doi: 10.1371/journal.pone.0155577

 

Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1STEM Mouse. Francois E. Mercier, David B. Sykes, David T. Scadden; Stem Cell Reports. 2016 May 11

 

Rhythmic expression of DEC2 protein in vitro and in vivo. Sato, F., Muragaki, Y., Kawamoto, T., Fujimoto, K., Kato, Y., Zhang, Y.”Rhythmic expression of DEC2 protein in vitro and in vivo”. Biomedical Reports 4.6 (2016): 704-710.

 

TAM receptors regulate multiple features of microglial physiology. Lawrence Fourgeaud, Paqui G. Través, Yusuf Tufail, Humberto Leal-Bailey, Erin D. Lew, Patrick G. Burrola, Perri Callaway, Anna Zagórska, Carla V. Rothlin, Axel Nimmerjahn & Greg Lemke, Nature. 2016 Apr 14;532(7598):240-4. doi: 10.1038/nature17630. Epub 2016 Apr 6

 

Impact of individual acute phase serum amyloid A (SAA) isoforms on HDL metabolism in mice.Myung-Hee Kim, Maria C. de Beer, Joanne M. Wroblewski1, Richard J. Charnigo, Ailing Ji1, Nancy R. Webb, Frederick C. DeBeer, Deneys R. van der Westhuyzen, NJ Lipid Res. 2016 Mar 27. pii: jlr.M062174.

 

MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.Anil Noronha Antony, Melanie Paillard, Cynthia Moffat, Egle Juskeviciute, Jason Correnti, Brad Bolon, Emanuel Rubin, György Csordás, Erin L. Seifert, Jan B. Hoek, and György Hajnóczkyc, Nat Commun. 2016; 7: 10955.

 

High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.Catherine K. Hathaway, Albert S. Chang, Ruriko Grant, Hyung-Suk Kim, Victoria J. Madden, C. Robert Bagnell, Jr., J. Charles Jennette, Oliver Smithies, and Masao Kakoki. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2218-22.

 

Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.Swapnil K. Sonkusare, Thomas Dalsgaard, Adrian D. Bonev, Mark T. Nelson J Physiol. 2016 Feb 3. doi: 10.1113/JP271652.

 

Col4a1 mutations cause progressive retinal neovascular defects and retinopathy.Marcel V. Alavi, Mao Mao, Bradley T. Pawlikowski, Manana Kvezereli, Jacque L. Duncan, Richard T. Libby, Simon W. M. John & Douglas B. Gould Scientific Reports 6, Article number: 18602 (2016) doi:10.1038/srep18602

 

Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons.Evanthia Nanou, Jane M. Sullivan, Todd Scheuer, and William A. Catterall PNAS January 26, 2016 vol. 113 no. 4 1062-1067

 

Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels.Evanthia Nanou, Jin Yan, Nicholas P. Whitehead, Min Jeong Kim, Stanley C. Froehner, Todd Scheuer, and William A. Catterall PNAS January 26, 2016 vol. 113 no. 4 1068-1073

2015

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene. Luna-Sánchez M, Díaz-Casado E, Barca E, Tejada MÁ, Montilla-García Á, Cobos EJ, Escames G, Acuña-Castroviejo D, Quinzii CM, López LC. EMBO Mol Med. 2015 Mar 23;7(5):670-87. doi: 10.15252/emmm.201404632.

 

Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption.Veedamali S Subramanian, Nils W. G. Lambrecht, Christian Lytle, Hamid M Said American Journal of Physiology – Gastrointestinal and Liver Physiology Published 10 December 2015 Vol. no. , DOI: 10.1152/ajpgi.00340.2015

 

Reduced white matter MRI transverse relaxation rate in cognitively normal H63D-HFE human carriers and H67D-HFE mice.Mark D. Meadowcroft , Jianli Wang, Carson J. Purnell, Douglas G. Peters, Paul J. Eslinger, Elizabeth B. Neely, David J. Gill, Megha Vasavada, Fatima Ali-Rahmani, Qing X. Yang, James R. Connor Brain Imaging Behav. 2015 Dec 11

 

Generation of Kcnma1fl-tdTomato, a conditional deletion of the BK channel α subunit in mouse.Betsir G. Zemen, Michael H. Lai, Joshua P. Whitt, Zulqarnain Khan, Guiling Zhao, Andrea L. Meredith Physiological Reports Published 4 November 2015 Vol. 3 no. e12612 DOI: 10.14814/phy2.12612

 

Generation and characterization of mice harboring a conditional CXCL12 allele Ryan E. Hillmer, Joanne P. Boisvert, Monica J. Cucciare, Michael B. Dwinell, and Milan Joksimovic, Int. J. Dev. Biol. 59: 205-209 (2015)

 

Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer’s Disease Soumitra Ghosh, Robert L. Geahlen, EBioMedicine. 3 Oct. 2015. Web. 9 Oct. 2015.

 

SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. Rahel Zulliger, Shannon M. Conley, Maggie L. Mwoyosvi, Michael W. Stuck, Seifollah Azadi, Muna I. Naash, Oncotarget PLoS ONE 10(9): e0138508. doi:10.1371/journal.pone.0138508

 

Oncoprotein mdig contributes to silica-induced pulmonary fibrosis by altering balance between Th17 and Treg T cells. Chitra Thakur, Michael Wolfarth, Jiaying Sun, Yadong Zhang, Yongju Lu, Lori Battelli, Dale W. Porter, and Fei Chen, Oncotarget 6.6 (2015): 3722–3736. Print.

 

Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase. Haymo Pircher, Susanne von Grafenstein, Thomas Diener, Christina Metzger, Eva Albertini, Andrea Taferner, Hermann Unterluggauer, Christian Kramer, Klaus R. Lied and Pidder Jansen-Dürr, J Biol Chem. 2015 Mar 13;290(11):6755-62. doi: 10.1074/jbc.M114.609305. Epub 2015 Jan 9.

 

CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. Benjamin Causton, Ravisankar A. Ramadas, Josalyn L. Cho, Khristianna Jones, Ana Pardo-Saganta, Jayaraj Rajagopal, Ramnik J. Xavier, and Benjamin D. Medoff, J Immunol. 2015 Jul 15;195(2):683-94. doi: 10.4049/jimmunol.1402983. Epub 2015 Jun 3.

 

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. Justin E Wilson, Alex S Petrucelli, Liang Chen, A Alicia Koblansky, Agnieszka D Truax, Yoshitaka Oyama, Arlin B Rogers, W June Brickey, Yuli Wang, Monika Schneider, Marcus Mühlbauer, Wei-Chun Chou, Brianne R Barker, Christian Jobin, Nancy L Allbritton, Dale A Ramsden, Beckley K Davis & Jenny P Y Ting, Nat Med. 2015 Aug;21(8):906-13. doi: 10.1038/nm.3908. Epub 2015 Jun 24.

 

Crucial role of nicotinic α5 subunit variants for Ca2+ fluxes in ventral midbrain neurons. Miriam Sciaccaluga, Claudia Moriconi, Katiuscia Martinello, Myriam Catalano, Isabel Bermudez, Jerry A. Stitzel, Uwe Maskos and Sergio Fucile, FASEB J. 2015 Aug;29(8):3389-98. doi: 10.1096/fj.14-268102. Epub 2015 Apr 24.

 

Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention. Marion Jeanne, Jeff Jorgensen, Douglas B. Gould, Circulation. 2015 May 5;131(18):1555-65. doi: 10.1161/CIRCULATIONAHA.114.013395. Epub 2015 Mar 9.

 

Regulatory T cells require TCR signaling for their suppressive function. Amanda M. Schmidt, Wen Lu, Vishal J. Sindhava, Yanping Huang, Janis K. Burkhardt, Enjun Yang, Matthew J. Riese, Jonathan S. Maltzman, Martha S. Jordan, and Taku Kambayashi, J Immunol. 2015 May 1;194(9):4362-70. doi: 10.4049/jimmunol.1402384. Epub 2015 Mar 27.

 

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Kyoung Wan Yoon, Sanguine Byun, Eunjeong Kwon, So-Young Hwang, Kiki Chu, Masatsugu Hiraki, Seung-Hee Jo, Astrid Weins, Samy Hakroush, Angelika Cebulla, David B. Sykes, Anna Greka, Peter Mundel, David E. Fisher, Anna Mandinova, Sam W. Lee, Science 31 July 2015: Vol. 349 no. 6247 DOI: 10.1126/science.1261669

 

Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo. Anne-Laure Joly, Sang Liua, Carin I.M. Dahlberg, Reiner K.W. Mailer, Lisa S. Westerberg, John Andersson, J Autoimmun. 2015 Jul 3. pii: S0896-8411(15)30002-0. doi: 10.1016/j.jaut.2015.06.009.

 

Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities. Olga Igoucheva1, Vitali Alexeev, Carmen M. Halabi, Sheila M. Adams, Ivan Stoilov, Takako Sasaki, Machiko Arita, Adele Donahue, Robert P. Mecham, David E. Birk, Mon-Li Chu J Biol Chem. 2015 Jul 15. pii: jbc.M115.640425.

 

VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism. Wei-Jye Lin, Cheng Jiang, Masato Sadahiro, Ozlem Bozdagi, Lucy Vulchanova, Cristina M. Alberini, and Stephen R. Salton J Neurosci. 2015 Jul 15;35(28):10343-56. doi: 10.1523/JNEUROSCI.0584-15.2015.

 

Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. Claes Bavik, Susan Hayes Henry, Yan Zhang, Kyoko Mitts, Tim McGinn, Ewa Budzynski, Andriy Pashko, Kuo Lee Lieu, Sheng Zhong, Bruce Blumberg, Vladimir Kuksa, Mark Orme, Ian Scott, Ahmad Fawzi, Ryo Kubota Nat Immunol. PLoS One. 2015 May 13;10(5):e0124940. doi: 10.1371/journal.pone.0124940

 

The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor. Corey R Seehus, Parinaz Aliahmad, Brian de la Torre, Iliyan D Iliev, Lindsay Spurka, Vincent A Funari & Jonathan Kaye. Nat Immunol. 2015 Apr 27. doi: 10.1038/ni.3168.

 

Kbtbd5 regulates skeletal muscle myogenesis through the E2F1-DP1 complex. Wuming Gong, Rachel M. Gohla, Kathy M. Bowlin, Naoko Koyano-Nakagawa, Daniel J. Garry, Xiaozhong Shi. J Biol Chem. 2015 May 4. pii: jbc.M114.629956.

 

Forkhead Box F2 Regulation of Platelet-derived Growth Factor and Myocardin/Serum Response Factor Signaling Is Essential for Intestinal Development. Craig Bolte, Xiaomeng Ren, Tatiana Tomley, Vladimir Ustiyan, Arun Pradhan, April Hoggatt, Tanya V. Kalin, B. Paul Herring and Vladimir V. Kalinichenko. J Biol Chem. 2015 Mar 20;290(12):7563-75. doi: 10.1074/jbc.M114.609487

 

Severe neutrophil-dominated inflammation and enhanced myelopoiesis in IL-33-overexpressing CMV/IL33 mice. Talabot-Ayer D, Martin P, Vesin C, Seemayer CA, Vigne S, Gabay C, Palmer G. J Immunol. 2015 Jan 15;194(2):750-60. doi: 10.4049/jimmunol.1402057

 

FAAH genetic variation enhances fronto-amygdala function in mouse and human. Iva Dincheva, Andrew T. Drysdale, Catherine A. Hartley, David C. Johnson, Deqiang Jing, Elizabeth C. King, Stephen Ra, J. Megan Gray, Ruirong Yang, Ann Marie DeGruccio, Chienchun Huang, Benjamin F. Cravatt, Charles E. Glatt, Matthew N. Hill, B. J. Casey & Francis S. Lee. Nature Communications. 2015 March 03 DOI: 10.1038/ncomms7395

 

The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Duygu Sag, Caglar Cekic, Runpei Wu, Joel Linden & Catherine C. Hedrick. Nature Communications. 27 Feb 2015 doi:10.1038/ncomms7354

 

Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of ‘humanized’ knockin mice expressing full length or truncated VGF. Masato Sadahiro1, Connor Erickson, Wei-Jye Lin, Andrew C. Shin, Maria Razzoli, Cheng Jiang, Samira Fargali1, Allison Gurney, Kevin A. Kelley, Christoph Buettner, Alessandro Bartolomucci, and Stephen R. Endocrinology. 2015 Feb 12 DOI: 10.1210/en.2014-1826

2014

Targeted disruption of the intracellular domain of receptor FgfrL1 in mice. Gilles Bluteau, Lei Zhuang, Ruth Amann, and Beat Trueb PLoS One. 2014 Aug 15;9(8):e105210. doi: 10.1371/journal.pone.0105210

 

Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery Melissa D. Thompson, Yu Mei, Robert M. Weisbrod, Marcy Silver, Praphulla C. Shukla, Victoria M. Bolotina, Richard A. Cohen, Xiaoyong Tong J Biol Chem. 2014 Jul 18;289(29):19907-16. doi: 10.1074/jbc.M114.554451.

 

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. Sang H. Min, Aae Suzuki, Timothy J. Stalker, Liang Zhao, Yuhuan Wang, Chris McKennan, Matthew J. Riese, Jessica F. Guzman, Suhong Zhang, Lurong Lian, Rohan Joshi, Ronghua Meng, Steven H. Seeholzer, John K. Choi, Gary Koretzky, Michael S. Marks, and Charles S. Abrams Nat Commun. 2014 Sep 2;5:4691. doi: 10.1038/ncomms5691

 

Global Gene Expression Profiling in R155H Knock-In Murine Model of VCP Disease Angèle Nalbandian, Svetlana Ghimbovschi, Zuyi Wang, Susan Knoblach, Katrina J. Llewellyn, Jouni Vesa, Eric P. Hoffman, Virginia E. Kimonis Clinical and Translational Science(2014)DOI: 10.1111/cts.12241

 

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity Maike Jaworski, Ben J Marsland, Jasmine Gehrig, Werner Held, Stéphanie Favre, Sanjiv A Luther, Mai Perroud, Déla Golshayan, Olivier Gaide, Margot Thome The EMBO Journal(2014)embj.201488987 DOI 10.15252/embj.201488987

 

Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits. Keigo Kohara, Michele Pignatelli, Alexander J. Rivest, Hae-Yoon Jung, Takashi Kitamura, Junghyup Suh, Dominic Frank, Koichiro Kajikawa, Nathan Mise, Yuichi Obata, Ian R. Wickersham, and Susumu Tonegawa Nat Neurosci. 2014 Feb;17(2):269-79. doi: 10.1038/nn.3614. Epub 2013 Dec 15.

 

Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. Yu Mei, Melissa D. Thompson, Yasunaga Shiraishi, Richard A. Cohen, Xiaoyong Tong J Mol Cell Cardiol. 2014 Nov;76:275-82. doi: 10.1016/j.yjmcc.2014.09.018. Epub 2014 Sep 28.

 

Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development. Claudio Cantù, Dario Zimmerli, George Hausmann, Tomas Valenta, Andreas Moor, Michel Aguet, and Konrad Basler Genes Dev. 2014 Sep 1;28(17):1879-84. doi: 10.1101/gad.246140.114.

 

Fhl1 W122S causes loss of protein function and late-onset mild myopathy Valentina Emmanuele, Akatsuki Kubota, Beatriz Garcia-Diaz, Caterina Garone, Hasan O. Akman, Daniel Sánchez-Gutiérrez, Luis M. Escudero, Shingo Kariya, Shunichi Homma, Kurenai Tanji, Catarina M. Quinzii, Michio Hirano Hum. Mol. Genet. 2014 Sept 30 doi: 10.1093/hmg/ddu490

 

The Y141C knockin mutation in RDS leads to complex phenotypes in the mouse Stuck MW, Conley SM, Naash MI. Hum Mol Genet. 2014 Jul 7. pii: ddu345.

 

Function of Latent TGFβ Binding Protein 4 and Fibulin 5 in Elastogenesis and Lung Development Branka Dabovic, Ian B. Robertson, Lior Zilberberg, Melinda Vassallo, Elaine C. Davis and Daniel B Rifkin. J Cell Physiol. 2014 Jun 24. doi: 10.1002/jcp.24704.

 

Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion Woo-Jin Song, Prosenjit Mondal, Andrew Wolfe, Laura C. Alonso, Rachel Stamateris, Benny W.T. Ong, Owen C. Lim, Kil S. Yang, Sally Radovick, Horacio J. Novaira, Emily A. Farber, Charles R. Farber, Stephen D. Turner1, Mehboob A. Hussain. Cell Metab. 2014 Apr 1;19(4):667-81.

 

Gene dosage of the transcription factor Fingerin (bHLHA9) affects digit development and links syndactyly to ectrodactyly Omri Schatz, Erez Langer and Nissim Ben-Arie. Hum Mol Genet. pii: ddu257.

 

STRA6 is critical for cellular vitamin A uptake and homeostasis Jaume Amengual, Ning Zhang, Mary Kemerer, Tadao Maeda, Krzysztof Palczewski, and Johannes von Lintig. Hum Mol Genet. pii: ddu258.

 

A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression Johanne Dubail, Noriko Aramaki-Hattori, Hannah L. Bader, Courtney M. Nelson, Negin Katebi, Brittany Matusk, Bjorn R. Olsen and Suneel S. Apte. Genesis. 2014 Apr 20. doi: 10.1002/dvg.22784.

 

Pro32Pro33 Mutations in the Integrin β3 PSI Domain Results in αIIbβ3 Priming and Enhanced Adhesion: Reversal of the Hypercoagulability Phenotype by the Src Inhibitor SKI-606 Kendra H Oliver, Tammy Jessen, Emily L Crawford, Chang Y Chung, James S Sutcliffe, and Ana M Carneiro. Mol Pharmacol. 2014 Jun;85(6):921-31.

 

Targeting SUR1/Abcc8-Type Neuroendocrine KATP Channels in Pancreatic Islet Cells Yumiko Nakamura and Joseph Bryan; PLoS One; 9(3): e91525

 

AAV-Mediated Overexpression of LARGE Rescues α-Dystroglycan Function in Dystrophic Mice with Mutations in the Fukutin-related Protein Vannoy C, Xu L, Keramaris E, Lu P, Xiao X, Lu Q.; Hum Gene Ther Methods. 2014 Mar 18.

 

Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling Zhu Z1, Todorova K, Lee KK, Wang J, Kwon E, Kehayov I, Kim HG, Kolev V, Dotto GP, Lee SW, Mandinova A; Cancer Res April 1, 2014. 74; 2082.

 

Cdc2-like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis through Disruption of the PGC-1α and MED1 Complex Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P.; Diabetes. 2014 May;63(5):1519-32.

 

The Pex1-G844D Mouse: A Model for Mild Human Zellweger Spectrum Disorder Hiebler S, Masuda T, Hacia JG, Moser AB, Faust PL, Liu A, Chowdhury N, Huang N, Lauer A, Bennett J, Watkins PA, Zack DJ, Braverman NE, Raymond GV, Steinberg SJ; Mol Genet Metab. 2014 Jan 23. pii: S1096-7192(14)00034-1.

 

Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells Tzong-Shyuan Tai, Sung-Yun Pai, I-Cheng Ho.; PLoS One. 2014 May 15;9(5):e96535

 

Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance Mansour AA, Khazanov-Zisman S, Netser Y, Klar A, Ben-Arie N.; Development;141(3):574-84.

 

Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival Jonathan A. Coleman, Xianjun Zhu, Hidayat R. Djajadi, Laurie L. Molday, Richard S. Smith, Richard T. Libby, Simon W. M. John and Robert S. Molday; ; 2014 Mar 1;127(Pt 5):1138-49.

 

Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC.; J Biol Chem. 2014 Jan 17;289(3):1491-504.

 

Targeted deletion of the gene encoding the La protein SSB autoantigen in B cells or cerebral cortex causes extensive tissue loss Gaidamakov S, Maximova OA, Chon H, Blewett NH, Wang H, Crawford AK, Day A, Tulchin N, Crouch RJ, Morse HC, Blitzer RD and Maraia RJ; Molecular and Cellular Biology; 34 (1) 123-131.

2013

Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Peter C.W. Lee, Jean-Cosme Dodart, Liviu Aron, Lydia W. Finley, Roderick T. Bronson, Marcia C. Haigis, Bruce A. Yankner, J. Wade Harper; Mol Cell. 2013 Apr 25;50(2):172-84. doi: 10.1016/j.molcel.2013.02.014.

 

Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, and Palczewski P; J Clin Invest. 2013 January 2; 123(1): 121–137.

 

Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Bruce E. Herring, Yun Shi, Young Ho Suh, Chan-Ying Zheng, Sabine M. Blankenship, Katherine W. Roche, and Roger A. Nicoll Neuron. 2013 Mar 20;77(6):1083-96. doi: 10.1016/j.neuron.2013.01.017.

 

Ablation of Kappa-Opioid Receptors from Brain Dopamine Neurons has Anxiolytic-Like Effects and Enhances Cocaine-Induced Plasticity Ashlee Van’t Veer, Anita J Bechtholt, Sara Onvani, David Potter, Yujun Wang, Lee-Yuan Liu-Chen, Günther Schütz, Elena H Chartoff, Uwe Rudolph, Bruce M Cohen and William A Carlezon; Neuropsychopharmacology. 2013 Jul;38(8):1585-97.

 

Second generation liposomal cancer therapeutics; Transition from laboratory to clinic Kacoli Sen, Mahitosh Mandal;: Int J Pharm. 2013 May 1;448(1):28-43.

 

Deregulation of the Protocadherin Gene FAT1 Alters Muscle Shapes: Implications for the Pathogenesis of Facioscapulohumeral Dystrophy Nathalie Caruso, Balàzs Herberth, Marc Bartoli, Francesca Puppo, Julie Dumonceaux, Angela Zimmermann, Simon Denadai, Marie Lebossé, Stephane Roche, Linda Geng, Frederique Magdinier, Shahram Attarian, Rafaelle Bernard, Flavio Maina, Nicolas Levy, Françoise Helmbacher; PLoS Genet. 2013 Jun;9(6):e1003550.

 

A progressive translational mouse model of human VCP disease Nalbandian A, Llewellyn K.J., Badadani M, Yin H.Z, Nguyen C, Katheria V, Watts G, Mukherjee J, Vesa J, Caiozzo V, Mozaffar T, Weiss J.H, Kimonis V.E; (2012); The VCP R155H/+ mouse; Muscle and Nerve; DOI: 10.1002/mus.23522

 

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity Zaida G Ramirez-Ortiz, William F Pendergraft III, Amit Prasad, Michael H Byrne, Tal Iram, Christopher J Blanchette, Andrew D Luster, Nir Hacohen, Joseph El Khoury & Terry K Means; Nat Immunol. 2013 Sep;14(9):917-26.

 

Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease Kosuke Tsukamoto, D. R. Mani, Jianru Shi, Songwen Zhang, Darrow E. Haagensen, Fumiyuki Otsuka, Jian Guan, Jonathan D. Smith, Wei Weng, Ronglih Liao, Frank D. Kolodgie, Renu Virmani, and Monty Krieger; Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17023-8.

 

Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response Fu Y, Westenbroek RE, Scheuer T, Catterall WA; Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19621-6.

 

Adeno-associated Virus 9 Mediated FKRP Gene Therapy Restores Functional Glycosylation of α-dystroglycan and Improves Muscle Functions Xu L, Lu PJ, Wang CH, Keramaris E, Qiao C, Xiao B, Blake DJ, Xiao X, Lu QL; Mol Ther;21(10):1832-40.

 

Regulation of 130-kDa Smooth Muscle Myosin Light Chain Kinase Expression by an Intronic CArG Element. Chen M, Zhang W, Lu X, Hoggatt AM, Gunst SJ, Kassab GS, Tune JD, Herring BP; J Biol Chem;288(48):34647-57.

 

Convergence of g protein-coupled receptor and s-nitrosylation signaling determines the outcome to cardiac ischemic injury Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ; Sci Signal.6(299):ra95

 

Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis Hanel W, Marchenko N, Xu S, Yu SX, Weng W, Moll U; Cell Death Differ. 2013 Jul;20(7):898-909.

 

B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates Ota T, Doyle-Cooper C, Cooper AB, Doores KJ, Aoki-Ota M, Le K, Schief WR, Wyatt RT, Burton DR, Nemazee D; J Immunol. 15;191(6):3179-85.

 

Activated Alveolar Epithelial Cells Initiate Fibrosis through Secretion of Mesenchymal Proteins Yang J, Wheeler SE, Velikoff M, Kleaveland KR, Lafemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK.; Am J Pathol ; pii: S0002-9440(13)00537-3.

 

Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia Johansson JU, Pradhan S, Lokteva LA, Woodling NS, Ko N, Brown HD, Wang Q, Loh C, Cekanaviciute E, Buckwalter M, Manning-Bog AB, Andreasson KI; J Neurosci.; 33(40):16016-32.

 

Mitochondrial respiration without ubiquinone biosynthesis Ying Wang and Siegfried Hekimi;Hum. Mol. Genet.; 22(23):4768-83.

 

Innate Immune-Directed NF-κB Signaling Requires Site-Specific NEMO Ubiquitination Janice C. Jun, Sylvia Kertesy, Mark B. Jones, Jill M. Marinis, Brian A. Cobb, Justine T. Tigno-Aranjuez, Derek W. Abbott; Cell Reports, Volume 4, Issue 2, 352-361

 

Mouse models of fukutin-related protein mutations show a wide range of disease phenotypes Anthony Blaeser, Elizabeth Keramaris, Yiumo M. Chan, Susan Sparks, Dale Cowley, Xiao Xiao, Qi Long Lu ; Human Genetics; 132(8):923-34.

 

Regulation of the Expression of GARP/Latent TGF-b1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation Justin P. Edwards, Hodaka Fujii, Angela X. Zhou, John Creemers, Derya Unutmaz, and Ethan M. Shevach; The Journal of Immunology; 190(11): 5506-15.

 

Disruption of Ttll5/Stamp gene (Tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2 associated modulatory protein gene) in male mice causes sperm malformation and infertility Geun-Shik Lee, Yuanzheng He, Edward J. Dougherty, Maria Jimenez-Movilla, Matteo Avella, Sean Grullon, David S. Sharlin, Chunhua Guo, John A. Blackford, Smita Awasthi, Zhenhuan Zhang, Stephen P. Armstrong, Edra C. London, Weiping Chen, Jurrien Dean and S. Stoney Simons; Journal of Biological Chemistry: 288: 15167-15180.

 

The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription Claudio Cantù, Tomas Valenta, George Hausmann, Nathalie Vilain, Michel Aguet, and Konrad Basler; Development; 140, 2377-2386.

 

The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress Julia S. Schlehe, Marion S.M. Journel, Kelsey P. Taylor, Katherine D. Amodeo, Matthew J. LaVoie; Neurobiology of Disease; 58; 57-67.

 

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure Helge Wiig, Agnes Schröder, Wolfgang Neuhofer, Jonathan Jantsch, Christoph Kopp, Tine V. Karlsen, Michael Boschmann, Jennifer Goss, Maija Bry, Natalia Rakova, Anke Dahlmann, Sven Brenner, Olav Tenstad, Harri Nurmi, Eero Mervaala, Hubertus Wagner, Franz-Xaver Beck, Dominik N. Müller, Dontscho Kerjaschki, Friedrich C. Luft, David G. Harrison, Kari Alitalo and Jens Titze; JCI; 123(7):2803–2815

 

An Extraribosomal Function of Ribosomal Protein L13a in Macrophages Resolves Inflammation Poddar D, Basu A, Baldwin WM III, Kondratov RV, Barik S, Mazumder B; The Journal of Immunology; 190(7): 3600-12

A Population of CRES Resides in the Outer Dense Fibers of Spermatozoa Marvin Ferrer, Gail Cornwall, and Richard Oko; Biol Reprod. 2013 Mar 14;88(3):65.

 

Generation of mice with a conditional Lbh null allele. Linsey E. Lindley, Karoline J. Briegel. Genesis. 2013 Jul;51(7):491-7.

 

SAA does not induce cytokine production in physiological conditions Kim M-H, de Beer MC, Wroblewski JM, Webb NR, de Beer FC; Cytokine; http://dx.doi.org/10.1016/j.cyto.2012.10.019

 

Selenoprotein N deficiency in mice is associated with abnormal lung development Moghadaszadeh B, Rider BE, Lawlor MW, Childers MK, Grange RW, Kushagra Gupta K, Boukedes SS,Owen CA and Beggs AH; The FASEB Journal; 27(4): 1585-99.

 

A Mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice Nandara W, Neelya EB, Ungerb E, Connor JR; Biochimica et Biophysica Acta (BBA) ; 1832(6); 729-41.

 

Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency García-Corzo L, Luna-Sánchez M, Doerrier C, García J.A, Guarás A, Acín-Pérez R, Bullejos-Peregrín J, López A, Germaine Escames G, José A. Enríquez J.A., Acuña-Castroviejo D and López LC; Hum. Mol. Genet. (2013) 22 (6): 1233-1248.

 

The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A Maria C. de Beer, Joanne M. Wroblewski, Victoria P. Noffsinger, et al; Journal of Lipids, vol. 2013, Article ID 283486, 11 pages.

2012

Increased neointimal formation in cystathionine gamma-lyase deficient mice: Role ofhydrogen sulfide in α5β1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells Guangdong Yang, Hongzhu Li, Guanghua Tang, Lingyun W, Kexin Zhao, Qiuhui C,Changqing Xu , Rui Wang; J Mol Cell Cardiol. 2012 Mar;52(3):677-88.

 

Ferroxidase Hephaestins Cell-Autonomous Role in the Retinal Pigment Epithelium Natalie Wolkow, Delu Song, Ying Song, Sally Chu, Majda Hadziahmetovic, Jennifer C. Lee, Jared Iacovelli, Steven Grieco, Joshua L. Dunaief; Am J Pathol. 2012 Apr;180(4).

 

Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. Popmihajlov Z, Xu D, Morgan H, Milligan Z, Smith KA.; Front Immunol. 2012 May 10;3:102. doi: 10.3389/fimmu.2012.00102. eCollection 2012.

 

Rgnef (p190RhoGEF) Knockout Inhibits RhoA Activity, Focal Adhesion Establishment, and Cell Motility Downstream of Integrins Nichol L. G. Miller, Christine Lawson, Xiao Lei Chen, Ssang-Taek Lim, David D. Schlaepfer; PLoS One. 2012;7(5):e37830.

 

Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain S González, C Rangel-Barajas2, M Peper, R Lorenzo, E Moreno, F Ciruela, J Borycz, J Ortiz, C Lluís, R Franco, P J McCormick, N D Volkow, M Rubinstein, B Floran and S Ferré; Mol Psychiatry. 2012 Jun;17(6):650-62.

 

Construction of Conditional Acid Ceramidase Knockout Mice and in vivo Effects on Oocyte Development and Fertility Eliyahu E., Shtraizent N., Shalgi R., Schuchman E.H.; Cell Physiol Biochem. 2012;30(3):735-48.

 

The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE; PLoS One. 2012;7(9):e46308.

 

Decreased levels of Ca2+-calmodulin-dependent protein kinase IV in the testis as a contributing factor to reduced fertility in male Crybb2-/- mice Fenfen Xiang, Bei Cui, Qian Gao, Jianrong Zhang, Junjie Zhang, Wenjie Li; Int J Mol Med. 2012 Nov;30(5):1145-51.

 

The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/− mice Lapointe J, Wang Y, Bigras E, and Hekimi S; JCB vol. 199 no. 2 215-224

 

Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding. Zou C, Levine EM.; PLoS Genet. 2012 Sep;8(9):e1002924.

 

Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling Hu Huang, Dong Kong, Kyung Hee Byun, Chianping Ye, Shuichi Koda, Dae Ho Lee, Byung-Chul Oh, Sam W Lee, Bonghee Lee, Janice M Zabolotny, Min Seon Kim, Christian Bjørbæk, Bradford B Lowell & Young-Bum Kim;Nature Neuroscience; 15, 1391–1398

 

Depletion of Endothelial or Smooth Muscle Cell-Specific Angiotensin II Type 1a Receptors Does Not Influence Aortic Aneurysms or Atherosclerosis in LDL Receptor Deficient Mice Rateri DL, Moorleghen JJ, Knight V, Balakrishnan A, Howatt DA, Cassis LA, Daugherty A; PLoS ONE 7(12): e51483

 

Stress-induced increase in skeletal muscle force requires PKA phosphorylation of the ryanodine receptor Andersson DC, Betzenhauser MJ, Reiken S, Umanskaya A, Shiomi T, Marks AR; The Journal of Physiology; online before print.

 

Enzymatic Relay Mechanism Stimulates Cyclic GMP Synthesis in Rod Photoresponse: Biochemical and Physiological Study in Guanylyl Cyclase Activating Protein 1 Knockout Mice Makino CL, Wen X-H, Olshevskaya EV, Peshenko IV, Savchenko AB, Dizhoor AM; PLoS ONE 7(10): e47637.

 

CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2 Soberman RJ, MacKay CR, Vaine CA, Ryan GB, Cerny AM, Thompson MR, Nikolic B, Primo V, Christmas P, Sheiffele P, Aronov L, Knipe DM, Evelyn A. Kurt-Jones EA; PLoS ONE 7(10): e47740.

 

Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption Ghosal A, Lambrecht NWG, Subramanya SB, Rubina Kapadia R, and Said HM; American Journal of Physiology – Gastrointestinal and Liver Physiology; online before print.

 

Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury Guillemot L, Schneider Y, Brun P, Castagliuolo I, Pizzuti D, Martines D, Jond L, Bongiovanni M and Citi S; Journal of Cell Science; doi: 10.1242/jcs.101261 PNAS; doi:10.1073/pnas.1204166109

 

Brefeldin A-inhibited Guanine Exchange Factor 2 Regulates Filamin A Phosphorylation and Neuronal Migration Zhang J, Neal J, Lian G, Shi B, Ferland RJ, and Sheen V; Journal of Neuroscience; 32(36): 12619-12629

 

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity Wang C, Lee J-E, Cho Y-W, Xiao Y, Jin Q, Liu C, and Ge K. PNAS; doi:10.1073/pnas.1204166109

 

Conditional Knockout of the Menkes Disease Copper Transporter Demonstrates Its Critical Role in Embryogenesis Wang Y, Zhu S, Weisman GA, Gitlin JD, Petris MJ ; PLoSONE 7(8): e43039. doi:10.1371/journal.pone.0043039

 

Long-term perturbation of spine plasticity results in distinct impairments of cognitive function VanLeeuwen J-E, Penzes P; Journal of Neurochemistry; DOI: 10.1111/j.1471-4159.2012.07899.x

 

Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice H Z Yin, A Nalbandian, C-I Hsu, S Li, K J Llewellyn, T Mozaffar, V E Kimonis and J H Weiss; Cell Death and Disease; e374; doi:10.1038/cddis.2012.115

 

The Mechanosensory Structure of the Hair Cell Requires Clarin-1, a Protein Encoded by Usher Syndrome III Causative Gene Geng R, Melki S, Chen D. H-C., Tian G, Furness D.N., Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt J.R., Imanishi Y, and Kumar N. Alagramam K.N; (2012); The Journal of Neuroscience; 2(28): 9485-9498

 

The Myc 3 Wnt Responsive Element Regulates Homeostasis and Regeneration in the Mouse Intestinal Tract Wesley M. Konsavage Jr., Ge Jin and Gregory S. Yochum; (2012); Molecular and Cellular Biology; doi: 10.1128/MCB.00548-12

 

Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins Robbins G.R, Truax A.D, Davis B.K, Zhang L, Brickey WJ, Ting J.P-Y; Journal of Biological Chemistry; First Published on May 29, 2012, doi: 10.1074/jbc.M112.364604

 

Transient Exposure of Neonatal Female Mice to Testosterone Abrogates the Sexual Dimorphism of Abdominal Aortic Aneurysm Zhang X, Thatcher SE, Rateri DL, Bruemmer D, Charnigo R, Daugherty A, Cassis LA; Circulation Research; April 26, 2012

 

Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance Agrawal PB, Joshi M, Savic T, Chen Z, and Alan H. Beggs AH; Human Mol Gen; March 5, 2012 doi:10.1093/hmg/dds053

 

Age-related changes in Cngb1-X1 knockout mice: prolonged cone survival Zhang Y, Rubin GR, Fineberg N, Huisingh C, McGwin G, Pittler SJ, and Kraft TW;Documenta Ophthalmologica;

 

Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment Cook JR, Smaldone S, Cozzolino C, del Solar M, Arteaga SL, Harikiran Nistala H, and Ramirez F; Genesis; 50(8):635-41

 

Defective Retinal Depolarizing Bipolar Cells (DBCs) in Regulators of G-protein Signaling (RGS) 7 and 11 Double Null Mice Shim H, Wang CT, Chen YL, Chau VC, Fu KG, Yang J, McQuiston AR, Fisher RA, and Chen CK; Journal of Biological Chemistry; 287, 14873-14879

 

Megakaryocyte development is normal in mice with targeted disruption of TescalcinUkarapong S , Bao Y, Perera EM, Berkovitz GD; Experimental Cell Research; 318(5); 662-669.

 

CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments Zinzow-Kramer MW, Long AB, Youngblood BA, Rosenthal KM, Butler R, Mohammed A-U-R, Skountzou I, Ahmed R, Evavold BD and Boss JM; Genes and Immunity; 13; 299-310

 

Modeling the Human MTM1p.R69C Mutation in Murine Mtm1 Results in Exon 4 Skipping and a Less Severe Myotubular Myopathy Phenotype Pierson CR, Dulin-Smith AN, Durban AN, Marshall ML, Marshall JT, Snyder AD, Naiyer N, Gladman JT, Chandler DS, Lawlor MW, Buj-Bello A, Dowling JJ, and Beggs AH; Human Mol. Gen.; (21)4; 811-825

2011

Na,K-ATPase α4 isoform is essential for sperm fertility Tamara Jimenez, Jeffrey P. McDermott, Gladis Sánchez, and Gustavo Blanco; Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):644-9.

 

Group X secretory phospholipase A2 augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice; Melissa Zack, Boris B. Boyanovsky, Preetha Shridas, William Bailey, Kathy Forrest, Deborah A. Howatt, Michael H. Gelb, Frederick C. de Beer, Alan Daugherty, Nancy R. Webb; Atherosclerosis. 2011 Jan;214(1):58-64

 

Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. (2011) Verma S1, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR; J Immunol. 2011 Feb 15;186(4):2127-37. doi: 10.4049/jimmunol.1002878. Epub 2011 Jan 10.

 

A transgenic mouse for in vivo detection of endogenous labeled mRNA. (2011) Timothée Lionnet, Kevin Czaplinski, Xavier Darzacq, Yaron Shav-Tal, Amber L. Wells, Jeffrey A. Chao, Hye Yoon Park, Valeria de Turris, Melissa Lopez-Jones, and Robert H. Singer; Nat Methods. 2011 Feb; 8(2): 165–170.

 

Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice. (2011) HDebra L. Rateri, Jessica J. Moorleghen, Anju Balakrishnan, A. Phillip Owens, Deborah A. Howatt, Venkateswaran Subramanian, Aruna Poduri, Richard Charnigo, Lisa A. Cassis, and Alan Daugherty; Circ Res. 2011 Mar 4; 108(5): 574–581

 

Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor Shanshan Huang, Joseph J. Ling, Su Yang, Xiao-Jiang Li and Shihua Li; Brain. 2011 Jul;134(Pt 7):1943-58.

 

Alterations in the Testis and Epididymis Associated With Loss of Function of the Cystatin-Related Epididymal Spermatogenic (CRES) Protein Adam D. Parent, Gail A. Cornwall, Lauren Y. Liu, Charles E. Smith, Louis Hermo; J Androl. 2011 Jul-Aug;32(4):444-63.

 

Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice Yiannikouris F, Karounos M, Charnigo R, English VL, Rateri DL, Daugherty A and Cassis LA; American Journal of Physiology Regulatory, Integrative and Comparative Physiology; November 2011, doi: 10.​1152

 

Leucine Zipper Putative Tumor Suppressor 2, LZTS2, Regulates Kidney Development Peng Y , Clark C, Luong R, Tu WH, Lee J, Johnson DT, Das A, Carroll TJ, Sun Z; Journal of Biological Chemistry; September 26, 2011

 

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S and Ting JPY; Immunity; 34(6); 854-865

 

SRY-Box Containing Gene 17 Regulates the Wnt/β-Catenin Signaling Pathway in Oligodendrocyte Progenitor Cells Chew LJ, Shen W, Ming X, Senatorov Jr VV, Chen HL, Cheng Y, Hong E, Knoblach K, and Gallo V; Journal of Neuriscience; 31(39):13921-13935

 

Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways Kazuhito Tsuboi, Yasuo Okamoto, Natsuki Ikematsu, Manami Inoue, Yoshibumi Shimizu, Toru Uyama, Jun Wang, Dale G. Deutsch, Matthew P. Burns, Nadine M. Ulloa, Akira Tokumura and Natsuo Ueda Biochim Biophys Acta. 2011 Oct;1811(10):565-77. doi: 10.1016/j.bbalip.2011.07.009. Epub 2011 Jul 23

 

Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis Xiaodong Ma, Munish Kumar, Saibyasachi N. Choudhury, Lindsey E. Becker Buscaglia, Juanita R. Barker, Keerthy Kanakamedala, Mo-Fang Liu, and Yong Li; PNAS; 108 (25) 10144-10149

 

Mouse transmembrane BAX inhibitor Motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system Joseph A. Nielsen, Meredith A. Chambers, Elena Romm, Laurel Yong-Hwa Lee, Jo Ann Berndt and Lynn D. Hudson; Molecular and Cellular Biology; DOI: 10.1007/s11010-011-0877-3

 

Characterization of a Sphingosine 1-phosphate Receptor Antagonist Prodrug Perry C. Kennedy, Ran Zhu, Tao Huang, Jose L. Tomsig, Thomas P. Mathews, Marion David, Olivier Peyruchaud, Timothy L. Macdonald, Kevin R. Lynch; Journal of Phamacology and Experimental Therapeutics; Online first DOI: 10.1124/jpet.111.181552

 

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling Andrew T. Templin, Bernhard Maier, Yurika Nishiki, Sarah A. Tersey and Raghavendra G. Mirmira; Cell Cycle; 10 (7); 1043-1049

 

Hippocampal phenotypes in kalirin-deficient mice Zhong Xie, Michael E. Cahill, Jelena Radulovic, Jing Wang, Susan L. Campbell, Courtney A. Miller, J. David Sweatt and Peter Penzes; Molecular and Cellular Neuroscience; 46 (1); 45-54

 

Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch DG, Ueda N and Hansen HS; Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids vol1811 (9), 2011, 508-512

 

G-Protein -Complex Is Crucial for Efficient Signal Amplification in Vision Kolesnikov AV, Rikimaru L, Hennig AK, Lukasiewicz PD, Fliesler SJ, Govardovskii VI, Kefalov VJ, and Kisselev OG; The Journal of Neuroscience, 1 June 2011, 31(22): 8067-8077

 

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenburg A, Wei Y, Vu TH; The Journal of Clinical Invest. 2011;121(7):2855–2862.

 

The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice; Bacchelli C, Buckland KF, Buckridge S, Salzer U, Schneider P, Thrasher AJ, Gaspar HB; J ALLERGY CLIN IMMUNOL, Vol 127 (5) May 2011, 1253-1273.

 

Group X Secretory Phospholipase A2 Enhances TLR4 Signaling in Macrophages Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR; The Journal of Immunology May 27, 2011 1003552

 

Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder Zubenko GS, Hughes III HB. 2011. Am J Med Genet Part B.

 

Deletion of the Distal C Terminus of CaV1.2 Channels Leads to Loss of β-Adrenergic Regulation and Heart Failure in Vivo; Fu Y, Westenbroek RE, Yu FH, Clark, JP III, Marshall MR, Scheuer T, Catterall WA; The Journal of Biological Chemistry, April 2011, 286, 12617-12626.

2010

Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse. Rolf Herrmann, Ekaterina S. Lobanova, Timothy Hammond, Christopher Kessler, Marie E. Burns, Laura J. Frishman, and Vadim Y. Arshavsky; J Neurosci. 2010 Mar 3; 30(9): 3239–3253.

 

Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells (2010) Yang G1, Wu L, Bryan S, Khaper N, Mani S, Wang R.; Cardiovascular Research (2010) 86, 487–495.

 

Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors (2010) Fairbridge NA, Dawe CE, Niri FH, Kooistra MK, King-Jones K, McDermid HE; Birth Defects Research; 88(8); 619–625

 

Reduced Fertility In Vitro in Mice Lacking the Cystatin CRES (Cystatin-Related Epididymal Spermatogenic): Rescue by Exposure of Spermatozoa to Dibutyryl cAMP and Isobutylmethylxanthine (2010) Chau KM, and Cornwall GA; Biology of reproduction;110.084855

 

FGF8 acts as a classic diffusible morphogen to pattern the neocortex (2010) Toyoda R, Assimacopoulos S, Wilcoxon J, Taylor A, Feldman P, Suzuki-Hirano A, Shimogori T, and Grove EA; Development; 137, 3439-3448.

 

Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo (2010) Slee EA, Benassi B, Goldin R, Zhong S, Ratnayaka I, Blandino G, and Lu X; PNAS; 107(45); 19479-19484.

 

MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling (2010) Liang J, Saad Y, Lei T, Wang J, Qi D, Yang Q, Kolattukudy PE, and Fu M; Journal of Experimental Med; 207(13) 2959-2973

 

Deletion of hensin/DMBT1 blocks conversion of β- to α-intercalated cells and induces distal renal tubular acidosis (2010) Gao XB, Eladari D, Leviel F, Yi Tew B, Miró-Julià C, Cheema F, Miller L, Nelson R, Păunescu TG, McKee M, Brown D, and Al-Awqati Q; PNAS; 107(50); 21872-21877.

 

Loss of STAT1 from Mouse Mammary Epithelium Results in an Increased Neu-Induced Tumor Burden (2010) Klover PJ, Muller WJ, Robinson GW, Pfeiffer RM, Yamaji D, and Lothar Hennighausen L; Neoplasia; 12(11): 899–905.

 

Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype (2010) Xua X, Yanga H, Lina YF, Lia X, Capea A, Resslerc KJ, Lia S, and Lia XJ;PNAS; 107 (44); 19126-19131

 

Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense (2010) Harashima A, Guettouche T and Barber GN;Genes & Development; 24; 2640-2653.

 

VCP Associated Inclusion Body Myopathy and Paget Disease of Bone Knock-In Mouse Model Exhibits Tissue Pathology Typical of Human Disease (2010) Badadani M, Nalbandian A, Watts G.D, Vesa J, Kitazawa M, Su H, Tanaja J, Dec E, Wallace D.C, Mukherjee J, Caiozzo V, Warman M, Kimonis V.E; PLosONE; 5(10): e13183

 

Kalirin loss results in cortical morphological alterations (2010) Xie Z, Cahill ME and Penzes P; Molecular and Cellular Neuroscience; 43(1); 81-89

 

A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter (2010) Geva M, Cabilly Y, Assaf Y, Mindroul N, Marom L, Raini G, Pinchasi D and Elroy-Stein O; Brain; 133 (8): 2448-2461

 

Fukutin-related protein is essential for mouse muscle, brain and eye development and mutation recapitulates the wide clinical spectrums of dystroglycanopathies (2010) Chan YM, Keramaris-Vrantsis E, Lidov HG, Norton JH, Zinchenko N, Gruber HE, Thresher R, Blake DJ, Ashar J, Rosenfeld J, and Lu QL; Hum. Mol. Genetics; 19 (20): 3995-4006.

 

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation (2010) Lim S-T, Chen XL, Tomar A, Miller NLG, Yoo J, and Schlaepfer DD;Journal of Biological Chemistry; 285, 21526-21536.

 

Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene; (2010) Zhou Y, Cheunsuchon P, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Zhang X, Gordon FE, Lidov HGW, Bronson RT, and Klibanski A ; Development; 137, 2643-2652

 

Functional muscle analysis of the Tcap knockout mouse (2010) C.D. Markert, M.P. Meaney, K.A. Voelker, R.W. Grange, H.W. Dalley, J.K. Cann, M. Ahmed, B. Bishwokarma, S.J. Walker, S.X. Yu, M. Brown, M.W.Lawlor, A.H. Beggs and M.K. Childers; Human Molecular Genetics, 2010, Vol. 19, No. 11 2268–2283

 

Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis (2010) Eckhardt ER, Witta J, Zhong J, Arsenescu R, Arsenescu V, Wang Y, Ghoshal S, de Beer MC, de Beer FC, de Villiers WJ. BMC Gastroenterol. 2010 Nov 10;10:133.

 

Impact of serum amyloid A on high density lipoprotein composition and levels (2010) Maria C. de Beer1, Nancy R. Webb*,. Joanne M. Wroblewski*,Victoria P. Noffsinger, Debra L. Rateri* Ailing Ji*Deneys R. van der Westhuyzen and Frederick C. de Beer* The Journal of Lipid Research, 51,; November 2010, 3117-3125

 

Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation (2010) Garilyn M Jentarra, Shannon L Olfers, Stephen G Rice, Nishit Srivastava, Gregg E Homanics, Mary Blue, SakkuBai Naidu, Vinodh Narayanan Neuroscience 2010, 11:19

 

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy(2010) Yuko Fukataa, Kathryn L. Loveroc, Tsuyoshi Iwanagaa, Atsushi Watanabed, Norihiko Yokoia, Katsuhiko Tabuchie,Ryuichi Shigemotoe, Roger A. Nicollc, and Masaki Fukataa PNAS. 2010 Feb 23;107(8):3799-804.

 

Cyclic Expression of Lhx2 Regulates Hair Formation (2010) Gunilla To¨ rnqvist., Anna Sandberg., Anna-Carin Ha¨gglund, Leif Carlsson Plos Genetics.April 2010.Volume 6.Issue 4.e1000904

 

Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice (2010) Valérie Besnard, Yohei Matsuzaki, Jean Clark, Yan Xu, Susan E. Wert, Machiko Ikegami, Mildred T. Stahlman, Timothy E. Weaver, Alan N. Hunt, Anthony D. Postle, and Jeffrey A. Whitsett American Journal of Physiology, Lung Cell Mol Physiol 298: L646–L659, 2010.

 

Role of CaMKIIδ phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure (2010) Alexander Kushnir, Jian Shan, Matthew J. Betzenhauser, Steven Reiken, and Andrew R. Marks PNAS | June 1, 2010 | vol. 107 | no. 22

 

Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation (2010)
Shannon E. Powers, Kenichiro Taniguchi, Weiwei Yen, Tiffany A. Melhuish, Jun Shen, Christopher A. Walsh, Ann E. Sutherland and David Wotton Development 137, 249-259 (2010) doi:10.1242/dev.040782

 

Impaired Intestinal Vitamin B1 (Thiamin) Uptake in Thiamin Transporter-2–Deficient Mice (2010) JACK C. REIDLING, NILS LAMBRECHT, MOHAMMAD KASSIR and HAMID M. SAIDGASTROENTEROLOGY 2010;138:1802–1809

 

ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel (2010) Bahrami, J., Yusta, B., Drucker, D.J. Gastroenterology (2009), doi: 10.1053/j.gastro.2010.03.006

 

Modulation of Angiotensin II–Mediated Cardiac Remodeling by the MEF2A Target Gene Xirp2 (2010) Sarah A. McCalmon, Danielle M. Desjardins, Saad Ahmad, Katharine S. Davidoff,Christine M. Snyder, Kaori Sato, Koji Ohashi, Ondra M. Kielbasa, Matthen Mathew,Elizabeth P. Ewen, Kenneth Walsh, Haralambos Gavras, Francisco J. Naya Circ. Res. 2010;106;952-960

 

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo (2010) David R. Gibb, Mohey El Shikh, Dae-Joong Kang, Warren J. Rowe, Rania El Sayed, Joanna Cichy, Hideo Yagita, John G. Tew, Peter J. Dempsey, Howard C. Crawford, and Daniel H. Conrad The Journal of Experimental Medicine, Vol. 207, No. 3, 623-635. February 15, 2010

 

ZFP191 is required by oligodendrocytes for CNS myelination (2010) Howng SY, Avila RL, Emery B, Traka M, Lin W, Watkins T, Cook S, Bronson R, Davisson M, Barres BA, Popko B. Genes Dev. 2010 Feb 1;24(3):301-11. Epub 2010 Jan 15

 

Human TUBB3 Mutations Perturb Microtubule Dynamics, Kinesin Interactions, and Axon Guidance (2010) Max A. Tischfield, Hagit N. Baris, Chen Wu, Guenther Rudolph, Lionel Van Maldergem, Wei He, Wai-Man Chan, Caroline Andrews, Joseph L. Demer, Richard L. Robertson, David A. Mackey, Jonathan B. Ruddle, Thomas D. Bird, Irene Gottlob, Christina Pieh, Elias I. Traboulsi, Scott L. Pomeroy, David G. Hunter, Janet S. Soul, Anna Newlin, Louise J. Sabol, Edward J. Doherty, Clara E. de Uzca´ tegui, Nicolas de Uzca´ tegui, Mary Louise Z. Collins, Emin C. Sener, Bettina Wabbels, Heide Hellebrand, Thomas Meitinger, Teresa de Berardinis, Adriano Magli, Costantino Schiavi, Marco Pastore-Trossello, Feray Koc, Agnes M. Wong, Alex V. Levin, Michael T. Geraghty, Maria Descartes, Maree Flaherty, Robyn V. Jamieson, H.U. Møller, Ingo Meuthen, David F. Callen, Janet Kerwin, Susan Lindsay, Alfons Meindl, Mohan L. Gupta, Jr., David Pellman, and Elizabeth C. Engle
Cell. Volume 140, Issue 1, 8 January 2010, Pages 74-87

2009

DNA Polymerase δ Is Required for Early Mammalian Embryogenesis ;(2009) Uchimura A, Hidaka Y, Hirabayashi T, Hirabayashi M, Yagi T; Plos One; 4(1); e418.

 

Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro; (2009) Miyagoe-Suzuki Y, Masubuchia N, Miyamotoa K, Wadaa MR, Yuasac S, Saitod F, Matsumurad K, Kanesakie H, Kudoe A, Manyaf H, Endof T and Takeda S; Mechanisms of Development; 126(3-4); 107-116.

 

Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone;(2009)
Robling AG, Childress P, Yu J, Cotte J, Heller A, Philip BK, Bidwell JP; Journal of Cellular Physiology; 219(3); 734 – 743.

 

Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity.; (2009) Zhang Y, Molday LL, Molday RS, Sarfare SS, Woodruff ML, Fain GL, Kraft TW, and Pittler SJ; Journal of Cell Science 122, 1192-1200.

 

Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis.; (2009) Amleh A, Nair SJ, Sun J, Sutherland A, Hasty P, Li R; PLoS ONE 4(4): e5034.

 

Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon.; (2009) Saint Fleur S, Hoshino A, Kondo K, Egawa T, and Fujii H; Blood; 114 (7); 1355-1365.

 

KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors.; (2009) Weinreich MA, Takada K, Skon C, Reiner SL, Jameson SC, and Hogquist KA; Immunity. 2009 Jul 17;31(1):9-11.

 

Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice.; (2009) Hoover RG, Gullickson G, and Kornbluth J; The Journal of Immunology; 183; 6913 -6921.

 

Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1.; (2009) Festing MH, Speer MY, Yang HY, Giachelli CM. Department of Bioengineering, University of Washington, Seattle, Washington.
Genesis. 2009 Oct 30;47(12):858-863

 

Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis.; (2009) Amleh A, Nair SJ, Sun J, Sutherland A, Hasty P, Li R. Plos One. 2009;4(4):e5034. Epub 2009 Apr 2

 

Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice.; (2009) Liu J, Zhang H, Li Z, Hailemariam TK, Chakraborty M, Qui D, Bui HH, Peake DA, Kuo MS, Wadgaonkar R, Cao G, Jiang XC. Arterioscler Thromb Vasc Biol. 2009 Mar 12.

 

Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro.; (2009) Yuko Miyagoe-Suzuki, Nami Masubuchia, Kaori Miyamoto, Michiko R. Wadaa, Shigeki Yuasac, Fumiaki Saitod, Kiichiro Matsumurad, Hironori Kanesakie, Akira Kudoe, Hiroshi Manyaf, Tamao Endof and Shin’ichi Takeda Mech Dev. 2009 Mar-Apr; 126(3-4): 107-16.

 

DNA polymerase delta is required for early mammalian embryogenesis.; (2009) Arikuni Uchimura, Yuko Hidaka, Takahiro Hirabayashi, Masumi Hirabayashi, Takeshi Yag Plos One. 2009; 4(1): e4184.

2008

DEC1 modulates the circadian phase of clock gene expression; (2008) Nakashima A, Kawamoto T, Honda KK, Ueshima T, Noshiro M, Iwata T, Fujimoto K, Kubo H, Honma S, Yorioka N, Kohno N, and Kato Y; Mol Cell Biol.; 28(12): 4080–4092.

 

Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin; (2008) Lüke Y, Zaim H, Karakesisoglou I, Jaeger VM, Sellin L, Lu W, Schneider M, Neumann S, Beijer A, Munck M, Padmakumar VC, Gloy J, Walz G and Noegel AA; Journal of Cell Science 121, 1887-1898.

 

Targeted knockout of the mouse betaB2-crystallin gene (Crybb2) induces age-related cataract; (2008) Zhang J, Li J, Huang C, Xue L, Peng Y, Fu Q, Gao L, Zhang J, and Li W; IOVS; 49(12); 5476-5483.

 

Complementation in trans of altered thymocite development in mice expressing mutant forms of the adaptor molecule SLP76; (2008) Jordan, M.S., Smith, J.E., Burns, J.C., Austin, J.E., Nichols, K.E., Aschenbrenner, A.C., Koretzky, G.A. Immunity. 2008 Mar; 28(3): 359-69.

 

Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate; (2008) Joesting, MS., Cheever, TR., Volzing, KG., Yamaguchi, TP., Wolf, V., Naf, D. Rubin, J.S., Marker, PC. Dev Biol. 2008 May 1; 317(1): 161-73.

 

Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport; (2008) Suzuki, Y., Kovacs, CS., Takanaga, H. Peng, J.B., Landowski, CP., Hedinger, MA. J Bone Miner Res. 2008 Aug; 23(8): 1249-56

 

Epithelial cells remove apoptotic epithelial cells during post-lactation involution of the mouse mammary gland; (2008) Monks, J., Smith-Steinhart C., Kruk ER., Fadok, VA., Henson, PM. Biol Reprod. 2008 Apr; 78(4): 586-94.

 

The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development; (2008) Beliakoff, Jason., Lee, Jane.,Ueno, Hiroo., Aiyer, Aparna., Weissman, Irving L., Barsh, Gregory S., Cardiff, Robert D., Sun, Zijie.
Mol Cell Biol. 2008 Jan; 28(1): 282-92.

 

A novel role of Sprouty 2 in regulating cellular apoptosis; (2008) Edwin, F., Patel, T.B. J Biol Chem. 2008 Feb 8; 283(6): 3181-90.

 

Retinopathy in mice induced by disrupted all-trans-retinal clearance; (2008) Akiko Maeda, Tadao Maeda, Marcin Golczak and Krzysztof Palczewski J Biol Chem. 2008 Sep 26; 283(39): 26684-93.

 

DEC1 modulates the circadian phase of clock gene expression; (2008) Ayumu Nakashima, Takeshi Kawamoto, Kiyomasa K. Honda, Taichi Ueshima, Mitsuhide Noshiro, Tomoyuki Iwata, Katsumi Fujimoto, Hiroshi Kubo, Sato Honma, Noriaki Yorioka, Nobuoki Kohno and Yukio Kato Mol Cell Biol. 2008 Jun; 28(12): 4080–92.

 

Defining the Importance of Phosphatidylserine Synthase-1 (PSS1); (2008) Devi Arikketh, Randy Nelson, and Jean E. Vance J Biol Chem. 2008 May 9; 283(19): 12888-97.

 

A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice; (2008) Clint L. Makino, Igor V. Peshenko, Xiao-Hong Wen, Elena V. Olshevskaya, Ronald Barrett, and Alexander M. Dizhoor J Biol Chem. 2008 Oct 24; 283(43): 29135-43

 

H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase; (2008) Guangdong Yang, Lingyun Wu, Bo Jiang, Wei Yang, Jiansong Qi, Kun Cao, Qinghe Meng, Asif K. Mustafa, Weitong Mu, Shengming Zhang, Solomon H. Snyder, Rui Wang Science. 2008 Oct 24; 322(5901): 587-90.

 

Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation; (2008) Tiruneh K. Hailemariam; Chongmin Huan; Jing Liu; Zhiqiang Li; Christopher Roman; Michael Kalbfeisch; Hai H. Bui; David A. Peake; Ming-Shang Kuo; Guoqing Cao; Raj Wadgaonkar; Xian-Cheng Jiang Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8): 1519-26.

 

Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation; (2008) TYoshikazu Imanishi12, Wenyu Sun1, Tadao Maeda, Akiko Maeda, and Krzysztof Palczewski J Biol Chem. 2008 Sep 5; 283(36): 25091-102.

 

Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin; (2008) Yvonne Lüke, Hafida Zaim, Iakowos Karakesisoglou, Verena M. Jaeger, Lorenz Sellin, Wenshu Lu, Maria Schneider, Sascha Neumann, Asa Beijer, Martina Munck, V. C. Padmakumar, Joachim Gloy, Gerd Walz and Angelika A. Noegel
J Cell Sci. 2008 Jun 1; 121 (Pt 11): 1887-98.

2007

Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation.; Claudia M. Krispel, Maxim Sokolov, Yen-Ming Chen, Hongman Song, Rolf Herrmann, Vadim Y. Arshavsky, and Marie E. Burns; J Gen Physiol. 2007 Sep;130(3):303-12.

 

Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2).; Fullerton, M.D., Hakimuddin, F., Bakovic, M.; (2007) Mol Cell Biol.; 27(9):3327-36.

 

Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.; Garcia-Gonzalez, M.A., Menezes, L.F., Piontek, K.B., Kaimori, J., Huso, D.L., Watnick, T., Onuchic, L.F., Guay-Woodford, L.M., and Germino, G.C.; (2007); Human Mol. Gen.; 16(16):1940-1950

 

Mitochondrial fusion protects against neurodegeneration in the cerebellum.; Chen, H., McCaffery, M.J., Chan, D.C.; Cell.; 130 (3): 548-62.

 

A Gne knockout mouse expressing human GNE D176V mutation develops features similar to distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy.; Malicdan, M.C.V., Noguchi, S., Nonaka, I., Hayashi, Y.K., and Nishino, I.; (2007); Human Mol. Gen.; 16(22); 2669-2682.

 

Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation.; Ding, C., Liu, Y., Wang, Y., Park, B.K., Wang, C., Zheng, P., Liu, Y.; (2007); PLoS One; 2(10): e997

 

Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm.; Baertschi, S., Zhuang, L., Trueb, B.; (2007); FEBS Journal; 274(23): 6241–53.

 

Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases.; Anderson, G.R., Lujan R., Semenov, A., Pravetoni, M., Posokhova, E.N., Song, J.H., Uversky, V., Chen, C., Wickman, K., Martemyanov, K.A.; (2007); J Neurosci.; 27: 27(51): 14117-27.

2006

Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.; Kim, K.I., Yan, M., Malakhova, O., Luo, J.K., Shen, M.F., Zou, W., de la Torre, J.C. and Zhang, D.E.; (2006); Mol Cell Biol; 26(2): 472-9.

 

The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells.; Park, J. M., Kohn, M. J., Bruinsma, M. W., Vech, C., Intine, R. V., Fuhrmann, S., Grinberg, A., Mukherjee, I., Love, P. E., Ko, M. S., DePamphilis, M. L., and Maraia, R. J.(2006); Mol Cell Biol; 26(4): 1445-51.

 

ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth.; Vives, V., Su, J., Zhong, S., Ratnayaka, I., Slee, E., Goldin, R., and Lu, X.; (2006); Genes & Dev; 20(10): 1262-7.

 

Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors.; Nanda, A., Karim, B., Peng, Z., Liu, G., Qiu, W., Gan, C., Vogelstein, B., St. Croix, B., Kinzler, K. W., and Huso, D. L.; (2006); Proc Natl Acad Sci.; 103 (9): 3351-6.

 

The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions.; Faria, A.M.C, Levay, A., Wang, Y., Kamphorst,A.O, Rosa, M.L.P, Nussenzveig, D.R., Balkan, W., Chook,Y.M., Levy, D.E., Fontoura, B.; (2006); Immunity; 24(3): 295-304.

 

Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure.; FDalkilic, I., Schienda, J.,Thompson, T.G.,Kunkel,L.M.; (2006); Mol Cell Biol.; 26(17): 6522–34.

 

Loss of the mouse ortholog of the shwachman-diamond syndrome gene (Sbds) results in early embryonic lethality.; Zhang, S., Shi, M., Hui, C., Rommens, J.M.; (2006); Mol Cell Biol.; 26(17): 6656-63.

 

Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration.; Vasireddy, V., Jablonski, M.M., Mandal, M.N.A., Raz-Prag, D., Wang, X.F., Nizol, L., Iannaccone, A., Musch, D.C., Bush, R.A., Salem Jr., N., Sieving, P.A. and Ayyagari, Radha; (2006); Invest Ophthalmol Vis Sci.; 47: 4558-4568.

 

Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.; McVay, LD, Keilbaugh, SA, Wong, TMH, Kierstein, S, Shin, ME, Lehrke, M, Lefterova, M, Shifflett, ED, Barnes, SL, Cominelli, F, Cohn, SM, Hecht G, Lazar, MA, Haczku, A, Wu, GD; (2006); J Clin Invest; 116: 2914-2923.

 

Lipin deficiency impairs diurnal metabolic fuel switching.; Xu, J.,F2 Lee, W.N. P., Phan, J., Saad M.F., Reue, K., and Kurland, I.J.; (2006); Diabetes; 55:3429-3438.

 

Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice.; Maeda, A., Maeda, T., Imanishi, Y., Sun, W., Jastrzebska, B., Hatala, D.A., Winkens, H.J., Hofmann, K.P., Janssen, J.J., Baehr, W., Driessen, C.A. and Palczewski, K.; (2006); J Biol Chem.; 281(49): 37697-704.

2005

Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice.; Shen J., and Walsh, C.A; (2005); Mol Cell Biol.; 25(9): 3639–3647

 

Targeted disruption of inducible 6-phosphofructo-2-kinase results in embryonic lethality.; Chesney, J., Telang, S., Yalcin, A., Clem, A., Wallis, N., Bucala, R.; (2005); Biochem Biophys Res Commun.; 1(331): 139-46.

2004

Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse.; Sokolov, M., Strissel, K.J., Leskov, I.B., Michaud, N.A., Govardovskii, V.I., and Arshavsky, V.Y.; (2004); J Biol Chem. 2004 Apr 20; 279(18): 19149-56.

 

Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development.; Uda, M., Ottolenghi, C., Crisponi, L., Garcia, J.E., Deiana, M., Kimber, W., Forabosco, A., Cao, A., Schlessinger, D., and Pilia, G.;(2004); Hum Mol Gen. 2004 Jun 1; 13(11): 1171-81.

 

Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver.; Batten, M.L., Imanishi, Y., Maeda, T., Tu, D.C., Moise, A.R., Bronson, D., Possin, D., Van Gelder, R.N., Baehr, W., and Palczewski, K.; (2004); J Biol Chem. 2004 Mar 12; 279(11): 10422-32.

 

Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets.; Ogg, S.L., Weldon, A.K., Dobbie, L., Smith, A.J., and Mather, I.H.;(2004); PNAS; 101(27): 10084-9.

 

TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response.; Utku, N., Boerner, A., Tomschegg, A., Bennai-Sanfourche, F., Bulwin, G.C., Heinemann, T., Loehler, J., Blumberg, R., and Volk, H.D.;(2004); J Immunol; 173: 2342-52.

 

RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis.; Zeng, Y., Takada, Y., Kjellstrom, S., Hiriyanna, K., Tanikawa, A., Wawrousek, A., Smaoui, N., Caruso, R., Bush, R.A., and Sieving, P.A.; (2004); Invest Ophthalmol Vis Sci; 45(9): 3279-85.

2003

Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation.; Muller, A.J., Baker, J.F., DuHadaway, J.B., Ge, K., Farmer, G., Donover, P.S., Meade, R., Reid, C., Grzanna, R., Roach, A.H., Shah, N., Soler, A.P., and Prendergast, G.C.; (2003); Mol Cell Biol. 2003 Jun; 23(12): 4295-306.

2001

Coupling of the TCR to integrin activation by Slap-130/Fyb.; Peterson, E.J., Woods, M.L., Dmowski, S.A., Derimanov, G., Jordan, M.S., Wu, J.N., Myung, P.S., Liu, Q.H., Pribila, J.T., Freedman, B.D., Shimizu, Y., and Koretzky, G.A.; (2001); Science. 93(5538): 2263-5.