Grant Writing Resources
Obtaining funding for the creation of a novel mouse model is increasingly difficult. Here are some tips to increase your chances of funding for your next novel mouse model. Learn to choose the right grant for funding your model and include the right information to guarantee it can be generated and display the expected phenotype.
1) Choosing a suitable grant
First and foremost, PI’s need to make sure that they are applying for a suitable grant. NIH R21 grants are better suited for a novel mouse model than R01 grants, because “The R21 grant mechanism is intended to encourage exploratory/developmental research by providing support for the early and conceptual stages of project development.” R01 applications will almost certainly fail if the second and third aims depend on the successful generation of a novel mouse model in the first.
2) Proving that a novel mouse model can be generated – guaranteed
The generation of a novel customized mouse model from scratch involves risks and uncertainty. However, inclusion of supporting material gained from other alleles of the same mouse gene or from human disease studies will enhance the chances of positive evaluation.
With the availability of the International Knockout Mouse Consortium (IKMC) public resources such as KOMP, EuCOMM, NorCOMM and TIGM etc and funding agencies strongly promoting use of such resources, projects incorporating these materials will more likely gain a higher score. However, information pertaining to targeting a specific gene available in the public resources greatly improves the chances of successful retargeting of this gene in a customized manner. Furthermore, this information may be utilized to argue why a novel mouse model is needed, and why the existing models will not suffice for your studies.
When considering mouse model production outsourcing to a specialized and dedicated company provides much more time and cost efficient solutions than in house generation. Furthermore ingenious offers a full service guarantee for generating mouse models from start to finish, thus protecting your funding.
3) Showing evidence that mouse model will display expected phenotype
If phenotypes have been described from other models of the same gene, then the chance that the new, customized model will have the desired phenotype is also higher. Data from a human disease linked to your novel mouse model will likely increase the funding score.
4) Providing detailed information
Finally, a crucial part for the grant application is that the PI provides detailed information as to how and where the model will be generated. ingenious’ experienced team of sales personnel and scientific advisors can help with such information by providing not only price estimates and sole source letters, but also providing scientific insight and feedback for a given gene and its structure in regards to a suitable strategy for your customized model. ingenious performs all essential quality control steps necessary to generate a model and with over 16 years of expertise, short time lines and a full service guarantee, we provide the most cost and time efficient solution to your customized needs.