Can a Common Humanized Mouse Model Solve Immunotherapy Related Problems?
If you are aware of how important a humanized mouse model can be in fields like cancer study and HIV research, you probably already know about other contributions. Humanized mice serve to offer researchers a great deal of help when it comes to dealing with immunology related obstacles when trying to enhance immunotherapy. These fields have a lot to do with the prospect of eliminating the negative impact of certain viruses that have plagued humanity for generations.
Humanized Mice and Immunotherapy
Humanized mice are superior to rodents for preclinical evaluation of the efficacy and safety of drug candidates using human cells or tissues. During the past decade, humanized mouse technology has been greatly advanced by the establishment of novel platforms of genetically modified immunodeficient mice. Several human diseases can be recapitulated using a humanized mouse model due to the improved engraftment and differentiation capacity of human cells or tissues. Immunology was one of the first fields to adopt multi-level humanization of mouse models. For the first time, immunotherapeutic drugs and treatments could be tested better relating to actual, human patients. This has led to remarkable breakthroughs in the field. Today, mice that were given humanized immune systems based on a variety of genetic manipulations, are frequently used to provide in vivo conditions that replicate immune and drug responses relating to the human body.
Immunodeficient Strains of Humanized Models
There are several important humanized mouse model strains that have been especially developed for the purpose of being used in the context of immunodeficiency and immunotherapy. The most common strain is the nonobese diabetic (NOD) severe combined immunodeficiency (NSG) strain, which was generated through the use of CD34+ stem cells. There are different variations of this strain that help create improved conditions for studying tumor tissue and the interaction between human cells and various cancer cells.
Leukemia Study – an Effective Application for Humanized Mouse Models
One of the most important applications of humanized mice has to do with the study and treatment of leukemia. Leukemia can be transferred to NSG mice that are grafted with oncogenic HSC. These models have already been used to provide evidence that suggests the the rejection of donor hematopoietic chimerism being closely linked to lymphopenia. According to researchers, the current xenograft models only permit the in vivo modeling of human tumors in hosts whose immune systems are completely compromised. However, with this mouse model, leukemia and other disorders can also be studied in secondary hosts that are in possession of an autologous human immune system. Such examples of scientific progress are often considered to be invaluable when it comes to the development of new and effective therapies.
Targeted Therapy and Humanized Mice
As of late, the use of humanized mouse model strains has been given full attention by the scientific community. This has happened especially since new mouse models were developed to not only support the pre-clinical study of immunotherapy, but also to induce improved response frequencies in patients through the use of targeted therapy. One good example is the work of Dr. Jonas Nilsson from the University of Gothenburg, whose team of scientists are pioneering the study of how viable it would be to consider modeling patient responses to reproduce them in rodent models. Such humanized mouse model strains are invaluable to the continual improvement of immunotherapeutics.
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