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Knockout Mice in the Study of Human Genetic Disease

Knockout Mice And Their Role in Disease Research Our understanding of human health and disease has been advanced immeasurably by research using knockout mouse models. In the thirty years since targeted gene knockouts were first demonstrated, thousands of these models have been created. For many human genetic diseases a specific gene is found to be associated with the disease but its
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What is the Mouse Knockout Timeline?

Understanding the timeline for generating knockout mice Today a founder mouse for a new knockout line can be generated in as little as 3 months. The pups of that founder can be genotyped 3-4 months after that, which is an essential step to confirm that a potential founder will pass on the mutation to the next generation. These short mouse knockout
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Incredible Results of Drug on Alzheimer’s Transgenic Mouse Model

Diabetes Drug Tested in Alzheimer’s mice “significantly reversed memory loss.” A drug developed for type 2 diabetes could be an effective way to treat Alzheimer’s disease. In recent research done in the UK, a drug developed for diabetes was tested in a transgenic mouse model of Alzheimer’s disease and showed significant improvement in neurocognitive function, through things such as maze testing.
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Natural Antiviral System Inspires New Tool For Researchers

“How will this system work if I remove one vital piece?” For researchers studying living organisms, answering this question is often a major component of their research. The system in question may be as small as three molecules or as large as a whole animal. Depending on the system and the nature of its components different tools are brought to bear.
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New CRISPR/Cas9 Application to Increase Crop Yields

CRISPR/Cas9 Technologies Many scientists believe that humanity is headed for a food shortage that has to be prevented as effectively as possible, by using and improving the CRISPR/Cas9 gene editing technologies that are available today. At the current growth rate, population increase can lead to the planet’s future agricultural demands becoming too great to address. A recent breakthrough made by plant
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Dawn of the Zombie Cells

Transgenic Mouse Study & the Zombie Cells   Oh, the beauty of ageing. The hair loss, the wrinkling of our skin, the loss of our eyesight, our diminishing cognitive memory…what joys. We’re all looking forward to it, right? Well, I guess not, but on the bright side, there might be some interesting breakthroughs to reverse this hideous truth…or at least slow
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