The Value Of Knockout Mouse Models

The Value Of Knockout Mouse Models

A Detailed Analysis of the Price and Value of Knockout Mouse Models

According to a recent report on the pricing analysis of knockout mouse models, there are many more factors involved in determining the monetary value of the mice, aside from the importance of the research studies they are used in.

Demand, availability, the complexity of the development process and the various licensing agreements associated with each specific mouse models are a few of the most significant criteria.

What Are Knockout and Knockin Mouse Models Used for?

Knockout mice are laboratory mouse models specially engineered to help scientists understand the genetic sources of various diseases such as diabetes, heart disease, arthritis, anxiety or Parkinson’s disease, and develop better treatments for them.

These mice are produced by either inactivating a specific gene thought to play a key role in the development of these diseases, or inserting a new DNA sequence – in the case of “knockin” mouse models. These techniques target the detailed study of gene activity.

One example is the p53 knockout mouse, which is named after a gene known as p53. This gene codes for a protein responsible in the suppression of tumor growths, and is widely used in cancer-related research studies. Aside from common debilitating diseases knockout mice can help us understand, like cancer and heart disease, other areas of research also includes substance abuse, aging and depression.

The Main Factors Responsible for Knockout Mouse Pricing

The price of a knockout mouse can depend heavily on the demand for specific mice and the development of new types of models that are more difficult to purchase or develop due to their complexity or unavailability. Models used in the treatment of cancer, for example, can be more expensive due to their demand, while those targeting less serious disorders are more affordable.

According to the report, however, demand and supply is only part of the story. Price variations can also be based on agreements and discounts established by those responsible for the production of mouse models, and the physiological traits of the mice also play an important role.

As such, the cost of mice developed for the study of more serious diseases like cardiovascular disease, or even some forms of cancer, has been reduced significantly in recent years due to their widespread availability. At the same time, neurological disorders and rare diseases are harder to counter using conditional knockouts, as their complexity and the limited funding allocated in the study of these health problems make the knockouts rarer and more expensive.

Constitutive and double knockout mouse models are less expensive, as the demand for some of these mice leads developing companies to reach their Break Even Point earlier and recover their investments more easily. This is one of the major factors contributing to the gradual reduction in pricing of mouse models that are in high demand.

The difference between prices set by established companies and that of lesser known brands associated with knockout mice is also thoroughly presented in the report, along with insight on the pricing attributed to the most important players in the industry.

Ultimately, the report helps stakeholders improve their business strategies by reassessing the market value of knockout mouse models, and pricing them accordingly. Stakeholders would, therefore, be able to increase their revenue share and customer base in order to improve profit and production.