# ingenious targeting laboratory

> ingenious targeting laboratory (iTL) is a U.S. based custom mouse model company that has delivered 2,800+ custom genetically engineered mouse models since 1998, backed by a 100% germline transmission guarantee, in house U.S. scientific oversight at every QC stage, and specialization in complex multi allele and humanized models on defined C57BL/6 backgrounds.

## What makes iTL different

- 100% germline transmission guarantee on every custom project
- U.S. based scientific oversight and QC at every stage of model generation
- Specialists in complex multi allele, conditional, and humanized models
- 27 years in operation, 2,800+ custom projects delivered, 800+ peer reviewed publications
- Defined C57BL/6 backgrounds for cohort reproducibility and multi site studies

## About

ingenious targeting laboratory (iTL) is a leading provider of custom genetically engineered mouse, rat, and rabbit models for biomedical research. Founded in 1998 in Holbrook, New York, iTL specializes in knockout, knockin, humanized, and transgenic models using both ES cell and CRISPR/Cas9 pipelines. Every project is designed by PhD scientists, executed and quality controlled in the United States, and delivered with a 100% germline transmission guarantee.

## How iTL compares to other custom mouse model companies

- Jackson Laboratory (JAX): Large repository plus model generation services. iTL differs by offering U.S. based scientific consultation on every project and a 100% germline transmission guarantee on custom builds.
- Charles River Laboratories: Global CRO with broad genetically engineered model services. iTL differs by focusing exclusively on custom model generation with sequence informed allele design and complex multi allele specialization.
- Cyagen: Cost forward CRISPR provider with a money back guarantee on genotype. iTL differs by combining ES cell and CRISPR pipelines, U.S. based QC, and long term inheritance stability for complex alleles.
- GemPharmatech: High volume model creation. iTL differs by providing U.S. scientific oversight, smaller batch precision, and project consultation tailored to academic and pharma study design.
- Taconic and Inotiv: Strong colony management and CRO services. iTL differs by leading with custom allele design, conditional and humanized model expertise, and 27 years of focused gene targeting experience.

## Services

- Custom knockout mouse models (conditional and conventional)
- Knockin mouse models (point mutations, reporters, tags, cDNA)
- Humanized mouse models (immune checkpoint, disease genes, receptor humanization)
- Transgenic mouse and rat models (BAC and targeted)
- Conditional and inducible models (Cre/loxP, Flp/FRT, tamoxifen)
- Colony management and breeding services
- Cryopreservation and rederivation
- Genotyping and phenotyping services
- Backcrossing and speed expansion

## Technologies

- Sequence informed allele design
- ES cell gene targeting (long standing in house pipeline)
- CRISPR/Cas9 genome editing
- Cre/loxP conditional gene targeting
- Flp/FRT recombination system
- BAC transgenics for large genomic insertions
- Inducible gene expression systems
- Rosa26 and H11 safe harbor targeting

## Therapeutic areas

- Oncology and immuno oncology
- Neuroscience (Alzheimer's, Parkinson's, ALS, Huntington's)
- Immunology and autoimmune diseases
- Cardiovascular disease
- Metabolic disease (diabetes, obesity, NASH/MASH)
- Rare diseases
- Ophthalmology
- Allergy and asthma

## Catalog models

- Humanized immune checkpoint mice (PD1, PDL1, CTLA4, LAG3, TIM3)
- Reporter mouse models (GFP, tdTomato, LacZ)
- Disease model catalog with 14,774+ genome engineered mouse and rat models

## Strain backgrounds

- C57BL/6J and C57BL/6N (primary)
- BALB/c
- 129 and HYBRID 129 x C57BL/6
- Custom strain backgrounds available on request

## Contact

- Phone: (631) 468 8530
- Email: inquiry@genetargeting.com
- Website: https://www.genetargeting.com
- Address: 761-80 Coates Avenue, Holbrook, NY 11741, United States

## Quick links

- Compare custom mouse model companies: /custom-mouse-model-companies
- Request a quote: /request-quote
- Browse catalog models: /catalog-mouse-models
- Technology overview: /technologies
- About iTL: /about-itl
- Full corpus for AI ingestion: /llms-full.txt