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Mouse Models

Why Should You Consider Making Transgenic Mice For Your Experiments?

Why should you consider making transgenic mice?

A Custom Transgenic Mouse Can Fit Your Research Goals Transgenic mice are genetically modified animals with an extra genetic sequence, called a transgene, permanently integrated into their genome. Making transgenic mice is a popular option for researchers because the sequence of the transgene is under the researcher’s control. With this flexibility different transgenic mice can […]

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Types Of Custom Mouse Models

Types Of Custom Mouse Models

Not sure which mouse model you need for your next study? Whether you’ve made mouse models before or you’re about to create your first one, the experts here at ingenious targeting laboratory have put together this helpful guide for your reference. Ready to get started? Get a custom quote from one of our scientific consultants […]

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A Need For Careful Screening In The Development Of CRISPR/Cas Lines

A Need for Careful Screening in the Development of CRISPR Cas Lines

What You Should Know from a Breeding and Genotyping Standpoint Standard applications of CRISPR/Cas9 as a genome editing tool aim to generate relatively small (up to several kb) targeted genetic mutations in the form of insertions, replacements, or deletions. Successful outcomes require both careful design of the genetic strategy and downstream screening efforts during subsequent […]

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Knockin Mice Used To Discover Cause Of Mitral Valve Prolapse

Knockin Mice Used To Discover Cause Of Mitral Valve Prolapse

DZIP1 Knockin Mouse Model A new mouse model of mitral valve prolapse, a common heart disease, was used to find a potential cause for this disease in humans. Characterized by a “clicking” sound in the chest and regurgitation of blood in the left atrium of the heart, this heart complication previously did not have any […]

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Bladder Drug May Increase Effects Of Atherosclerosis In Mice

Bladder Drug May Increase Effects Of Atherosclerosis In Mice

Mirabegron in mice shown to increase risk of cardiovascular complications Mouse models were used to discover that mirabegron, a popular drug for the treatment of overactive bladder, may increase the likelihood of blocked arteries, cardiovascular disease, and stroke in patients with atherosclerosis. The mice for this study contained mutations in the ApoE gene or in […]

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Light Flickers Shown to Help Mouse Models of Alzheimer’s Disease

Light Flickers Shown To Help Mouse Models Of Alzheimers Disease

Light therapy may protect against neurodegeneration Researchers at MIT have published exciting new data on a potential treatment to reduce the severity of Alzheimer’s disease (AD), as seen in mouse models. They previously found that physical signs of AD, such as protein plaques in the brain, could be reduced by a regimen of light therapy. […]

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Memory And Seizures Improved In Mouse Models Of Autism With Gene Editing

Memory and Seizures Improved in Mouse Models of Autism with Gene Editing

Correcting genetic causes for neurodevelopmental disorders in adults A new study conducted by scientists at The Scripps Research Institute in Florida asserts that it’s possible to correct symptoms from a genetic cause of autism in adults, not just in infancy or early childhood as it has been believed. They used a mouse model where one […]

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Common Food Additive May Weaken Flu Vaccine, As Seen In Mouse Models

Common Food Additive May Weaken Flu Vaccine, As Seen In Mouse Models

The relationship between tBHQ and immune response Researchers at Michigan State University have discovered that a widely-used additive found in crackers, frozen meat, and other foods, suppressed the immune system’s ability to fight the flu in mouse models. The additive, known as tert-butylhydroquinone (tBHQ), may also render the flu vaccine less effective, which was demonstrated […]

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Green Tea And Carrot Compounds Improved Cognition In Mouse Models Of AD

Green Tea And Carrot Compounds Improved Cognition In Mouse Models Of AD

Effects of EGCG and FA compounds on memory Mouse models of Alzheimer’s disease experienced improved working memory after medical scientists fed them a diet of compounds found in green tea and carrots. The team of researchers from the University of Southern California looked to test how two compounds, epigallocatechin-3-gallate (EGCG) and ferulic acid, would work […]

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Excitation-Inhibition Balance Theory Of Autism Examined In Mouse Models

Excitation-Inhibition Balance Theory Of Autism Examined In Mouse Models

Effects of the E-I ratio on “spiking” By studying four mouse models of autism, researchers at the University of California, Berkeley discovered that altering the balance of excitation and inhibition of neurons in the brain does not affect hyperexcitability, also known as “spiking,” challenging a popular theory in the field. The excitation-inhibition balance theory proposes […]

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Effects Of Climate Change In Mouse Models With Influenza Virus

Effects Of Climate Change In Mouse Models With Influenza Virus

How the immune system can be affected by climate change It is predicted that climate change will reduce crop yields and the nutritional value in food over time, as well as increase the infection range of insects that spread disease. However, how heat waves affect the immune system when exposed to common viruses has not […]

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Mouse Models With Mutated Immune Cells Showed Risk Of Alzheimer’s Disease

Mouse Models With Mutated Immune Cells Showed Risk Of Alzheimer's Disease

Activating TREM2 as an early-stage therapy for AD In a study published in Nature Neuroscience, scientists from the German Center for Neurodegenerative Diseases and the Ludwig-Maximilians-University Munich discovered the TREM2 gene’s relationship with brain health. This gene works to activate microglia in the brain, which eliminate toxic deposits that can accumulate and lead to forms […]

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Coffee Compounds May Protect Mouse Models From Parkinson’s Disease

Coffee Compounds May Protect Mouse Models From Parkinson's Disease

These two compounds could protect against neurodegeneration While previous research has suggested that drinking coffee can potentially reduce the risk of Parkinson’s disease, scientists at Rutgers University have narrowed down the two compounds that could be fighting this condition. They discovered that a fatty acid called EHT (eicosanoyl-5-hydroxytryptamide), which can be found in the coating […]

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Ultrasound Technology Captures Whole-Brain Imaging In Mice

Ultrasound Technology Captures Whole-Brain Imaging In Mice

Advantages of functional ultrasound imaging According to a new study in Neuron, scientists are now able to capture unbiased whole-brain images of behavior in awake mice using functional ultrasound technology. These high-resolution activity maps can provide a deeper system-level understanding of a particular behavior of interest. Compared to fMRI and other whole-brain imaging technologies, functional […]

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