The Challenges of Obtaining an ES Cell Line to Fight Neurological Diseases
Neurological disorders and injuries such as spinal cord injuries (SCI) have long been known to present significant issues to medical experts who try to prescribe a viable treatment against them. While there are conventional treatments and drugs that could help, there are no solutions that were regarded as “permanent” until the time when the study of neurological treatment was shifted to the field of cell-based therapies. The use of human embryonic stem cell lines for the purpose of producing regenerative tissue has been proposed and used successfully through a number of treatments in the past few years. Studies even show promising results, and very few side effects are being reported.
Before Using ES Cell Lines for SCI and Other Neurological Disorders
Spinal cord injuries are conditions that lead to the complete or partial paralyzing of the patient below the level of the injury. For example, if a certain patient develops a spinal cord injury in the lower back area, they might be stuck in a wheelchair all their life, as a result of being unable to move the lower half of their body, including their legs and feet. Unfortunately, no known cure exists against SCI, although several treatments have been used with some degree of success. Aside from surgical intervention, the main treatment options include the lowering of body temperature, the use of corticosteroids and the application of various forms of physiotherapy.
How MNs Can Be Grown from Stem Cells
The year 2010 has seen the first body of stem cell research work responsible for the differentiation of motoneurons from human ES cells. The neuron tissue has an exceptional potential for treating and even curing some spinal disorders, including ALS and spinal cord injury. Since isolating MNs from human tissue is not practical, the only remaining option is to use human embryonic stem cells – seeing as animal stem cells suffer from the problem of species variation. A revolutionary stem line labeled NSI-566RSC was obtained from an 8-week old fetal spinal cord to obtain viable MNs that were subsequently tested on mice and later on humans.
ES Cell Studies and Successful Treatments
Although other studies have also attempted the use of neural progenitor cells from adults and non-neural progenitor cells derived from various other organs, human embryonic stem cell lines remained the best choice for obtaining regenerative tissue that could be used against SCI. The results were nothing short of amazing. A study conducted by Geeta Shroff and Rakesh Gupta used human ES cells to treat five paraplegic and quadriplegic patients. After the treatment, all patients were able to sit, maintain their balance and move their lower and upper limbs more easily without any side effects. Another study achieved similar results with 226 patients, proving that ES cell therapy is safe and effective.
The Proper Administering of Human ES Cells
Research has shown that using the correct dosage of stem cells can be tricky. However, many patients have shown significant improvement when the dosage stayed between 1 and 5 ml for every 7-10 days, along with small doses of 0.25 ml administered on a daily basis. The stem cells are administered intramuscularly, and doctors report that the results obtained through these dosages are more than promising. Today, human ES cell therapy is viewed as an excellent treatment option for SCI and other similar disorders, and practical studies continue to show that the risks of developing adverse effects after the therapy are close to none.