"A better model is within reach."


Cre-Lox Facts


6 Facts You May Not Know About Cre-Lox The basics of conditional knockout mice are familiar to any researcher who uses mouse models, even if this model type isn’t yet a part of your research. Using the Cre-lox system in an experiment seems simple: two lines are crossed, one with tissue-specific expression of Cre and […]

Tags: , , , ,

Read more

Gaining Inducible Control

inducible control

Inducible Control of Your Tissue-Specific Animal Model The Cre-lox system is commonly used to provide tissue-specific gene knockout.  In order for this to happen in vivo, two mouse lines are mated together – The tissue-specific Cre line and a second mouse line containing your gene of interest flanked by loxP sites (floxed mouse). Cre recombines […]

Tags: , , , , ,

Read more