"A better model is within reach."

Knockout

Gaining Inducible Control

inducible control

By Kristen Coughlin Inducible Control of Your Tissue-Specific Animal Model The Cre-lox system is commonly used to provide tissue-specific gene knockout.  In order for this to happen in vivo, two mouse lines are mated together – The tissue-specific Cre line and a second mouse line containing your gene of interest flanked by loxP sites (floxed […]

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CRISPR Gene Knockout

Crispr Gene Knockout by INGENIOUS

Advanced Genetics: The Benefits and Uses of CRISPR Gene Knockout CRISPR gene knockout techniques have become highly popular in recent years, as scientists have used the technique countless times to research the influence that certain genes have on the mouse genome. Knockout mice offer impressive insight into the inner workings of the human genome, due […]

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Knockout Mice Purpose

Knockout Mice Purpose by INGENIOUS

Researching Knockout Mice – Purpose and Understanding of Long Term Benefits When it comes to knockout mice, their purpose in research has already had a profound effect on our understanding of human genetics. We’re uncovering the underlying causes of conditions like cancer, diabetes, heart disease and many other debilitating disorders. Genetic research conducted on mice […]

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Knockout Mice Method

Knockout Mice Method by INGENIOUS

Using the Knockout Mice Method to Find Relevant Gene Information – Essential Steps and Useful Information The knockout mice method has been known since 1989, when researchers Martin Evans, Oliver Smithies and Mario R. Capecchi came up with the first successful procedure of creating a healthy knockout mouse that could deliver its knockout gene to […]

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How A Knockout Mouse Is Made

How A Knockout Mouse Is Made by INGENIOUS

How a Knockout Mouse is Made – Types of Methods and Specific Procedures Understanding how a knockout mouse is made is not necessarily an easy task. In recent years, with advancements in technology and the development of methods that can be easier to understand, the science has become available for transgenic facilities to streamline the […]

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Gene Knockout Method

Gene Knockout Method by INGENIOUS

The Search for the Best Gene Knockout Method for Achieving Targeted Results The gene knockout method is a popular tool for genetic manipulation that researchers usually associate with mouse models designed to study specific diseases and new treatment methods. Gene knockouts are often targeted towards specific genes and mutations that are meant to achieve a […]

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Conventional vs. Conditional Knockout

Conventional Vs Conditional Knockout by INGENIOUS

Conventional vs. Conditional Knockout Mice – The Superiority of Advanced Conditional Knockout Technologies There are many reasons why the issue of conventional vs. conditional knockout mouse models is solved through a clear superiority of advanced conditional methods. Traditional knockouts were originally considered the most advanced engineered knockout laboratory mice. Some of the latest techniques in […]

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Conventional Knockout

Conventional Knockout by INGENIOUS

Gaining a Deeper Understanding About Conventional Knockout Mice and Their Role in Genetic Research Genetic research has come a long way in the past few years alone as a result of advancements made with the help of conventional knockout animal models. The knockout process is designed to inactivate a gene in an organism with the […]

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Conditional Knockout Mice

Conditional Knockout Mice by INGENIOUS

A Look at Conditional Knockout Mice and the Methods Used to Create Them Conditional knockout mice play a critical role in genetics and biology research, because they allow scientists to manage how and when a specific gene is deleted. Genes can have different functions during an individual’s lifespan. Most dramatically, a gene may be essential […]

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Mouse Knockout Screen Leads To Discovery

Mouse Knockout Screen Leads To Discovery

Novel Hearing-Related Genes Identified by Mouse Knockout Screen Detailed analysis of 3006 lines of knockout mice has identified 67 genes related to hearing, including 52 genes not previously associated with that process. This result was made possible by the work of the International Mouse Phenotyping Consortium (IMPC), a group with the goal of testing the […]

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The Value Of Knockout Mouse Models

The Value Of Knockout Mouse Models

A Detailed Analysis of the Price and Value of Knockout Mouse Models According to a recent report on the pricing analysis of knockout mouse models, there are many more factors involved in determining the monetary value of the mice, aside from the importance of the research studies they are used in. Demand, availability, the complexity […]

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Knockout Mice In Cushing’s Syndrome Research

Knockout Mice In Cushing's Syndrome Research

New Insight on the Effects of the ARMC5 Gene on Patients Suffering from Cushing’s Syndrome Genetic experiments and knockout mice have recently helped scientists at the University of Montreal Hospital Research Centre (CRCHUM) gain new insight on the effects that eliminating a specific gene known as ARMC5 can have in inducing particular ailments and predispositions […]

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Knockout Mouse In Circadian Rhythm Study

Knockout Mouse In Circadian Rhythm Study

Scientists Discover a Faster and More Accurate Method of Studying the Circadian Rhythm Nearly all animals that follow a 24-hour cycle are subject to the famous circadian rhythms – the physiological shifts that regulate our biology at a cellular level. These inner biological clocks are affected by numerous genetic factors that have a strong impact […]

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Reversible Infantile Liver Failure

Reversible Infantile Liver Failure

The Study of RILF Through a Genetically Modified Murine Mouse Model While studying RILF (reversible infantile liver failure), a mitochondrial disease that can cause severe unbalance in liver functions during infancy, scientists in Japan have found that they can explore the mechanisms involved with the progress of the condition through the use of a new […]

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Cardiac Health

Cardiac Knockout Mice

Cardiac Knockout Mice Show Role of Gene in Fat Metabolism Scientists know that the heart predominantly uses lipids as fuel in order to function. However, recent research conducted by molecular biologist Dr. Weiqin Chen of Augusta University seems to reveal that both too many and too few of the lipid droplets required for normal heart […]

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