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Knockout

Gaining Inducible Control

inducible control

Inducible Control of Your Tissue-Specific Animal Model The Cre-lox system is commonly used to provide tissue-specific gene knockout.  In order for this to happen in vivo, two mouse lines are mated together – The tissue-specific Cre line and a second mouse line containing your gene of interest flanked by loxP sites (floxed mouse). Cre recombines […]

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How A Knockout Mouse Is Made

How A Knockout Mouse Is Made by INGENIOUS

How a Knockout Mouse is Made – Types of Methods and Specific Procedures Understanding how a knockout mouse is made is not necessarily an easy task. In recent years, with advancements in technology and the development of methods that can be easier to understand, the science has become available for transgenic facilities to streamline the […]

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Mouse Knockout Screen Identifies Hearing-Related Genes

Mouse Knockout Screen Leads To Discovery

Hearing Genes Identified by Mouse Knockout Screen Detailed analysis of 3006 lines of gene knockout mice has identified 67 genes related to hearing, including 52 not previously associated with that process. This result was made possible by the work of the International Mouse Phenotyping Consortium (IMPC), a group with the goal of testing the function […]

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The Value Of Knockout Mouse Models

The Value Of Knockout Mouse Models

A Detailed Analysis of the Price and Value of Knockout Mouse Models According to a recent report on the pricing analysis of knockout mouse models, there are many more factors involved in determining the monetary value of the mice, aside from the importance of the research studies they are used in. Demand, availability, the complexity […]

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Knockout Mice In Cushing’s Syndrome Research

Knockout Mice In Cushing's Syndrome Research

New Insight on the Effects of the ARMC5 Gene on Patients Suffering from Cushing’s Syndrome Genetic experiments and knockout mice have recently helped scientists at the University of Montreal Hospital Research Centre (CRCHUM) gain new insight on the effects that eliminating a specific gene known as ARMC5 can have in inducing particular ailments and predispositions […]

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Knockout Mouse In Circadian Rhythm Study

Knockout Mouse In Circadian Rhythm Study

Scientists Discover a Faster and More Accurate Method of Studying the Circadian Rhythm Nearly all animals that follow a 24-hour cycle are subject to the famous circadian rhythms – the physiological shifts that regulate our biology at a cellular level. These inner biological clocks are affected by numerous genetic factors that have a strong impact […]

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Reversible Infantile Liver Failure

Reversible Infantile Liver Failure

The Study of RILF Through a Genetically Modified Murine Mouse Model While studying RILF (reversible infantile liver failure), a mitochondrial disease that can cause severe unbalance in liver functions during infancy, scientists in Japan have found that they can explore the mechanisms involved with the progress of the condition through the use of a new […]

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Cardiac Health

Cardiac Knockout Mice

Cardiac Knockout Mice Show Role of Gene in Fat Metabolism Scientists know that the heart predominantly uses lipids as fuel in order to function. However, recent research conducted by molecular biologist Dr. Weiqin Chen of Augusta University seems to reveal that both too many and too few of the lipid droplets required for normal heart […]

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