"A better model is within reach."

Mouse models

Why Make A Humanized Mouse?

Why Make A Humanized Mouse?

By Kristen Coughlin Humanized Mouse Models The mouse has been used for over 30 years as a model system for studying human disease. Recently, “humanized” mice have grown in popularity because they are formidable models of the human being and therefore extremely useful for understanding the human condition. What exactly is a humanized mouse? A humanized […]

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3 Things I Wish I Knew Before Making My First Knockin Mouse Model

knockin mouse model

My First Knockin Mouse Model Creating a new mouse model is a major step in any research program. Some things may have come to mind such as, “Can’t I finish this project using models that already exist?” or “Will I ever graduate if I undertake a knockin mouse model project?” If you have reached a […]

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Humanized Mouse Model

Humanized Mouse Model

Can a Common Humanized Mouse Model Solve Immunotherapy Related Problems? If you are aware of how important a humanized mouse model can be in fields like cancer study and HIV research, you probably already know about other contributions. Humanized mice serve to offer researchers a great deal of help when it comes to dealing with […]

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Humanized Mice

Humanized Mice

What Are Humanized Mice and Why Are They Really Used? With an increase in the advancement of modern techniques used for genetic manipulation, humanized mice have become an important asset. These mice are used to mimic human conditions and apply potential therapies more efficiently, without any of the risks involved with using human patients. Also, […]

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Transgenic Mouse Model

Transgenic Mouse Model

The Benefits and Drawbacks of the Transgenic Mouse Model When Modeling Human Disease When it comes to evaluating the benefits and disadvantages of using a transgenic mouse model to test a hypothesis about disorders affected by genetics, there are many important points to remember. Importantly, transgenic models can be highly effective in evaluating the reason […]

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Transgenic Mice

Transgenic Mice

What Are Transgenic Mice and Why Are They Important in Genetic Research? When considering the drugs we take to alleviate the symptoms of disease, never would we have imagined how important transgenic laboratory mice are to drug development. However, these mice are of pivotal importance in the genetic research necessary to achieve the relief we […]

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Cre-Lox Facts

cre-lox

6 Facts You May Not Know About Cre-Lox By Richard Row, PhD The basics of conditional knockout mice are familiar to any researcher who uses mouse models, even if this model type isn’t yet a part of your research. Using the Cre-lox system in an experiment seems simple: two lines are crossed, one with tissue-specific […]

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Gene Knockin Mouse

gene knockin

By Jennifer Parla, Ph.D. Aha! I Need a Knockin Mouse… Now What? Moving to animal studies At the start of your research, a live animal model may not have been necessary. You may have been studying a biochemical pathway or process that is highly conserved and can be investigated using cultured cells or sometimes with cell-free […]

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Mouse Model of Lymphoma

conditional point mutation

Taking Control with a Conditional Point Mutation Model When designing a point mutation mouse model you should ask yourself, “Is a mouse with this mutation present in every cell the best model for my research?” It may make more sense to only express mutant sequence in specific cells, for example when making a cancer model. There […]

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CRISPR Mice

Crispr Mice by INGENIOUS

The Prospect of Using CRISPR Mice and the Future of Medical Research Many new breakthroughs were possible through the use of CRISPR mice. The CRISPR technique is one of the most groundbreaking new achievements in genetic research, and it works remarkably well to achieve knockout and transgenic mouse models for genetic research purposes. For anyone […]

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CRISPR Knockout

Crispr Knockout by INGENIOUS

Generating a CRISPR Knockout – Important Thoughts on the CRISPR/Cas Technique Generating a CRISPR knockout is easier than ever with advanced and highly simplified techniques like CRISPR/Cas9. The CRISPR Cas system has been in use for years, and it’s already helped researchers achieve some important breakthroughs in the field of medicine and genetic engineering. With […]

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A Conditional Knockout That Took Research Further

conditional knockout model

The Right Myopathy Model After years of work in in vitro systems and cultured cells your research may reach a point where an animal model is required. This major transition requires a new mindset, and consideration of factors that didn’t previously affect experiments. When evaluating genetically modified animal models each stage of their life must […]

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Knockout Mice Purpose

Knockout Mice Purpose by INGENIOUS

Researching Knockout Mice – Purpose and Understanding of Long Term Benefits When it comes to knockout mice, their purpose in research has already had a profound effect on our understanding of human genetics. We’re uncovering the underlying causes of conditions like cancer, diabetes, heart disease and many other debilitating disorders. Genetic research conducted on mice […]

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Knockout Mice Method

Knockout Mice Method by INGENIOUS

Using the Knockout Mice Method to Find Relevant Gene Information – Essential Steps and Useful Information The knockout mice method has been known since 1989, when researchers Martin Evans, Oliver Smithies and Mario R. Capecchi came up with the first successful procedure of creating a healthy knockout mouse that could deliver its knockout gene to […]

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