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Mouse models

Why Make A Humanized Mouse?

Why Make A Humanized Mouse?

Humanized Mouse Models The mouse has been used for over 30 years as a model system for studying human disease. Recently, “humanized” mice have grown in popularity because they are formidable models of the human being and therefore extremely useful for understanding the human condition. What exactly is a humanized mouse? A humanized mouse is a […]

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3 Things I Wish I Knew Before Making My First Knockin Mouse Model

knockin mouse model

My First Knockin Mouse Model Creating a new mouse model is a major step in any research program. Some things may have come to mind such as, “Can’t I finish this project using models that already exist?” or “Will I ever graduate if I undertake a knockin mouse model project?” If you have reached a […]

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Cre-Lox Facts

cre-lox

6 Facts You May Not Know About Cre-Lox The basics of conditional knockout mice are familiar to any researcher who uses mouse models, even if this model type isn’t yet a part of your research. Using the Cre-lox system in an experiment seems simple: two lines are crossed, one with tissue-specific expression of Cre and […]

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Gene Knockin Mouse

Aha! I Need a Gene Knockin Mouse... Now What?

Aha! I Need a Gene Knockin Mouse… Now What? Moving to animal studies At the start of your research, a live animal model may not have been necessary. You may have been studying a biochemical pathway or process that is highly conserved and can be investigated using cultured cells or sometimes with cell-free assays. Or […]

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Mouse Model of Lymphoma

conditional point mutation

Taking Control with a Conditional Point Mutation Model When designing a point mutation mouse model you should ask yourself, “Is a mouse with this mutation present in every cell the best model for my research?” It may make more sense to only express mutant sequence in specific cells, for example when making a cancer model. There […]

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A Conditional Knockout That Took Research Further

conditional knockout model

The Right Myopathy Model After years of work in in vitro systems and cultured cells your research may reach a point where an animal model is required. This major transition requires a new mindset, and consideration of factors that didn’t previously affect experiments. When evaluating genetically modified animal models each stage of their life must […]

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How Do I Start My Custom Model Project?

custom model

Begin your custom animal model in 3, 2, 1… Gene of interest? Check. Model type? Check. Species and strain? Check. Great, let’s get started! When you are ready to start a custom animal model project with us, we’re ready to move your project forward, too. Step 1: Sign your project quote and let your sales […]

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Knockout Mice In The Study Of Human Genetic Disease

genetic disease

Knockout Mice and Their Role in Disease Research Our understanding of human health and disease has been advanced immeasurably by research using knockout mouse models. In the thirty years since targeted gene knockouts were first demonstrated, thousands of these models have been created. For many human genetic diseases a specific gene is found to be […]

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Eye Microbiome Trigger Immune Response In Mice Models

eye microbiome

Study Proves a Resident Ocular Microbiome “Bugs in your eyes may be a good thing.” New research is showing that immune responses that protect the eye from infection are due to microbes living on the surface of the eye. Research conducted at the National Eye Institute (NEI), part of the National Institutes of Health, indicates […]

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Recent Client Publications!

research model

Congratulations to our Clients Congratulations to our Clients Dr. Douglas Gould from UCSF School of Medicine, Dr. Ichizo Nishino from National Institute of Neuroscience, Japan, & Dr. Jian-xing Ma from University of Oklahoma Health Sciences Center. Their research and publications included the use of conditional knockout models, and point mutation knockin mouse models from ingenious. They now are among the hundreds […]

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A New Humanized Mouse Model

A New Humanized Mouse Model

A New Humanized Mouse Model Leads to New Opportunities in Treating Colorectal Cancer While immunotherapy is effective in the case of many different types of cancer, colorectal cancers have always presented scientists with far greater challenges, due to being “microsatellite stable.” According to Julie Lang, PhD, the CU Cancer Center’s senior research associate, a new […]

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Genistein And Breast Cancer Tumors

Genistein And Breast Cancer Tumors

Genistein and Breast Cancer Tumors: Should Soy Consumption Be Halted in Breast Cancer Patients? According to recent scientific findings, the positive or negative effects associated with breast cancer patients consuming soy products can differ according to when the food was consumed. Patients who had already eaten soy products prior to their diagnosis might actually benefit […]

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The Value Of Knockout Mouse Models

The Value Of Knockout Mouse Models

A Detailed Analysis of the Price and Value of Knockout Mouse Models According to a recent report on the pricing analysis of knockout mouse models, there are many more factors involved in determining the monetary value of the mice, aside from the importance of the research studies they are used in. Demand, availability, the complexity […]

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Humanized Mice Used In Newborn Jaundice Research

Advanced Treatments Aiming to Stop the Development of Newborn Jaundice A condition known as jaundice is responsible for many health risks and problems involving newborn babies, particularly in lesser developed countries throughout Africa and South Asia, where treatments such as blood transfusions are not as readily available as in developed countries. Newborn jaundice is caused […]

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Gene Therapy And Usher Syndrome

Gene Therapy And Usher Syndrome

The Promising Results in Using Gene Therapy to Treat Usher Syndrome Patients Gene therapy has advanced considerably in recent years, due particularly to mutant mouse models genetically modified to mimic the effects of health problems like deafness and help test effective treatments. Various studies published this February in Nature Biotechnology showed the progress researchers have […]

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