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All Articles (20)
Insights into Neurodegenerative Diseases: Alzheimer’s Disease Progression and Treatments
Mouse models expressing human genes implicated in Alzheimer’s disease provided valuable insights into disease progression [1] . In a recent article, researchers used these models to study the...
Advances in Metabolic Disorders Research: Obesity and Diabetes
Recently developed genetically engineered mouse models have played a pivotal role in advancing our understanding of metabolic diseases, particularly in insulin resistance and obesity. These mouse...
Developments in Immune and Infectious Diseases: Insights from humanized models
The ongoing battle against COVID-19 highlighted the need for effective models to study SARS-CoV-2 infection. Researchers developed humanized mouse models expressing the human ACE2 (the receptor for...
Breakthroughs in Cancer Research: Innovations in Immunotherapy
Mouse Models & CRISPR: Revolutionizing Cancer Immunotherapy Immunotherapy has transformed cancer treatment, and mouse models have been pivotal in this progress. Recent advancements in cancer research...
Advancements in Gene Editing Technologies: Enhancements in CRISPR-Cas9
CRISPR: Revolutionizing Research, But at What Cost? Gene editing technologies have rapidly evolved, with CRISPR-Cas9 at the forefront of these advancements, revolutionizing how researchers study...
Building Better Floxed Alleles for Conditional Knockout Mice
1. Why floxed alleles still matter For most therapeutic areas, full germline knockouts are blunt instruments. Developmental lethality, compensation, and systemic effects make it hard to infer...
Conventional Vs. Conditional Knockout Mice
Knockout mice were once the cutting edge of genetic engineering for modeling diseases. However traditional conventional knockouts came with an important limitation for biological experimentation....
Cre-Lox: 6 Facts You May Not Know
Conditional knockout (cKO) mice are now basic infrastructure in in vivo biology. The core Cre-lox logic looks simple: cross a tissue-specific Cre line with a floxed allele, get tissue-specific loss...
How Humanized Mouse Models Are Transforming Pre-clinical R&D
Harnessing Humanized Mouse Models Preclinical Disease Models That Deliver Better Predictive Power The accelerating costs of biomedical R&D and the high failure rates of clinical trials have...
How To Obtain A Conditional Knockout
Introduction Conditional knockout mice have become indispensable tools in preclinical research. Since their introduction in the mid-90s, they have enabled researchers to inactivate genes in specific...
How a Knockout Mouse Is Made
Understanding how knockout mice are generated is essential for biomedical researchers. Recent advances in genome editing have dramatically streamlined this process, enabling labs to create knockout...
Inside the Humanized Mouse: Engineering the Human Immune System
Harnessing Humanized Mouse Models Preclinical Disease Models That Deliver Better Predictive Power In Part 1 of this series, we explored the translational gap that continues to undermine drug...
Knock-In Mice vs. Transgenic Mice: What You Need to Know
Knock-in and transgenic mice are foundational tools in biomedical research, yet their strategic differences drive distinct experimental outcomes and value. Both play key roles and accelerated our...
Leveraging Mouse Models for Point Mutation Diseases: R&D Landscape
How precision mouse genetics is de-risking mutation-targeted therapies from discovery to approval Point mutation diseases have moved from niche academic focus to the core of high-value pipelines in...
Model vs. Model: Humanized Mice Compared to Organoids, Chips, and AI
Model vs. Model: How Humanized Mice Compare to Organoids, Chips, and AI Preclinical Disease Models That Deliver Better Predictive Power In part 3 we explored how multi-cytokine and dual-organ...
Modeling Complexity: Multi-Cytokine and Multi-Organ Humanization
Modeling Complexity: Multi-Cytokine and Multi-Organ Humanization Preclinical Disease Models That Deliver Better Predictive Power In part 2 of this series on humanized mouse models, we examined how...
The Impact of Knockout and Knock-in Mouse Models on Biomedical Research
Knockout and knock-in mouse models have fundamentally transformed biomedical research, enabling scientists to dissect gene function and the genetic basis of many diseases. Through precise genetic...
Top 5 Lab Mouse Colony Management Software Options For 2025
Managing a mouse colony effectively is a critical but often underestimated aspect of laboratory research. Whether you’re creating a new mouse model tailored to your study or purchasing an existing...
Translating Promise into Practice – Clinical Applications, CROs, and the Future
Part 5: Translating Promise into Practice – Clinical Applications, CROs, and the Future Preclinical Disease Models That Deliver Better Predictive Power In Part 4 we examined how organoids, chips, and...
Inducible Systems 2026: Controlling Gene Expression With Precision
Inducible systems enable researchers to control gene expression with precision in terms of where, when, and how much a gene is active. By choosing the right system for the job, scientists can design experiments that were unimaginable a decade ago.
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