Custom Mouse Models
We create genetically engineered mouse models aligned with your genetic, regulatory, and phenotype-driven research questions—supporting precise allele design and background control.
Learn More→Custom Mouse Models Designed for Study-Ready, Reproducible Research
ingenious targeting laboratory creates custom genetically engineered mouse models (GEMMs) designed for stable inheritance, controlled C57BL/6 backgrounds, and reproducible experimental cohorts. For more than two decades, researchers have partnered with our U.S.–based scientific team to achieve sequence-informed allele design, rigorous QC oversight, and study-ready, germline-transmitting mouse lines.
ingenious targeting laboratory helps researchers determine the most appropriate approach for long-term allele stability, clear genotype interpretation, and successful model creation.
Core Research Services
Cohort Development
Study-ready cohorts on C57BL/6 backgrounds with structured breeding to support statistical power and multi-site reproducibility.
Learn More→Catalog Library
Access our catalog of 10,000+ genome engineered mouse and rat models for study-ready scientific discovery.
Learn More→Preclinical Services
Non-GLP phenotype characterization, PK/PD, pharmacology, and exploratory in-vivo support for your custom or catalog animal models.
Learn More→Overview
Why Researchers Choose ingenious targeting laboratory
For more than 25 years, ingenious targeting laboratory has supported biomedical research with animal models that provide stable allele designs, reproducible cohorts, C57BL/6 backgrounds, and U.S.-based QC oversight. Each project follows an evidence-based, results-driven approach to deliver animal models with reliable inheritance and long-term performance.
What We Provide
- Custom mouse models including conventional knockouts, conditional knockouts, knock-ins (point mutation, cDNA, gene replacement), reporter alleles, Rosa26 and other targeted transgenics, and humanized models.
- Multi-generation cohort development and colony planning for study readiness.
- Animal model catalog access to 10,000+ lines for study-ready biomedical research.
- Integrated non-GLP preclinical services for your custom or catalog model to support translational decisions.
Modern Model-Generation Landscape
Across today's research environment, scientists utilize a wide array of genome-modification technologies, including programmable nucleases, rapid-editing strategies, exploratory one-cell–stage modifications, and other contemporary editing systems used throughout the field. These approaches and others are discussed with an emphasis on structured allele design, stable inheritance, and multi-generational reproducibility for long-term performance aligned with your specific study requirements.
ingenious targeting laboratory's High-Level Approach
Optimized Targeting Strategy
We evaluate all available genome engineering technologies to determine the best method for your specific research goals. Technology selection is based on allele complexity, stability requirements, and reproducibility standards.
U.S.-Based QC Oversight
Each stage of custom development—allele confirmation, germline transmission, colony establishment, and cohort expansion—is validated through U.S.-based QC. This comprehensive oversight ensures consistent quality and reliable results across all project phases.
Project Backgrounds
The C57BL/6 background ensures reproducibility across cohorts, replicates, and multi-site studies to eliminate confounding variables and support consistent phenotypic outcomes.
Structured Allele Design
Allele designs are chosen to support reliable and consistent performance across downstream assays. This includes constitutive knockout, conditional knockout, reporter gene insertion, knock-in (point mutation, cDNA), and humanization projects, all designed to maintain stable inheritance and interpretable outcomes across generations.
Conceptual Workflow
Our systematic approach ensures consistent results from project initiation through delivery of study-ready cohorts:
1
Project Consultation
Free scientific consultation to review experimental goals, recommend optimal targeting strategies, and provide timeline and pricing estimates.
2
Allele Design
Custom allele design development based on your research requirements, including selection of appropriate targeting approach and cassette configuration.
3
Targeting Materials
Design and synthesis of targeting materials, including sequence verification and quality control.
4
Germline Transmission
Injection and breeding of F0s to achieve germline transmission.
5
Cohort Development
Study-ready cohort expansion with structured breeding for statistical power.
Trusted by Researchers Worldwide
Since 1998 · 2,500+ Projects Completed · 800+ Peer Reviewed Publications · Nature · Science · Cell
ingenious targeting laboratory has generated custom mouse models for researchers at leading academic institutions, pharmaceutical companies, and biotechnology organizations worldwide. Our models have contributed to research published in the most prestigious scientific journals.
What Researchers Say
“The Hephaestin flox model ingenious has made for us has been great. It has helped generate eight research publications.”
— Joshua Dunaief, PhD, MD
University of Pennsylvania
“The rat knock-in model from ingenious was reliable, precise, and accelerated our immunology research significantly.”
— Carla Rothlin, Professor and Director of Center of Immunology
Yale University
“ingenious Targeting Laboratory is highly recommended for generating custom animal models. Past 2 years, we have made 2 conditional knockout mouse lines. All processes of each project were scientifically and professionally handled. Their scientific consulting to initiate the project was superb compared to other companies, and transparency of the project progress reported by project managers was excellent. Their excellency and dedication to meet our needs in a timely manner are invaluable to continuation of our research progress.”
— Hyekyung Plumley, PhD
Warren Center for Neuroscience Drug Discovery
“iTL produced a new conditional mouse model for us and the quality of service was exceptional. The team is extremely knowledgeable and the work was completed at the highest possible standards. My project manager was excellent and always happy to answer technical questions and keep me up to date with progress and potential problems. I would recommend iTL highly and will use them again in the future if I need to generate a new mouse line.”
— Albert Basson, PhD
King's College London
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Start Your Project
Our scientific consultants are ready to discuss your research requirements and recommend the optimal approach for your project. Initial consultation is provided at no charge and includes allele design recommendations, timeline estimates, and project pricing.