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Respiratory Disease Models

Allergy Asthma Mouse Models

Since 1998, ingenious targeting laboratory has supported allergy and asthma research with custom mouse models enabling mechanistic studies of airway inflammation, allergic responses, and therapeutic interventions. Our allergy and asthma models have contributed to research on Th2 immune responses, airway remodeling, and anti inflammatory therapeutics.

Allergy and asthma mouse models provide essential platforms for investigating the molecular pathways underlying allergic inflammation, testing hypotheses about immune cell contributions, and developing therapies for respiratory diseases affecting millions of patients worldwide.

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Allergy and Asthma Disease Mechanisms

Th2 Immune Responses

Allergic asthma involves Th2 mediated inflammation:

  • IL4, IL5, IL13 production
  • Eosinophil recruitment
  • IgE production
  • Airway hyperresponsiveness

Airway Remodeling

Chronic inflammation leads to:

  • Epithelial changes
  • Smooth muscle hypertrophy
  • Mucus production
  • Basement membrane thickening

Model Types

Induced Asthma Models

Models using allergen sensitization:

OVA (ovalbumin) sensitization

Classic allergen sensitization model for airway inflammation studies

House dust mite models

Clinically relevant allergen for chronic airway disease

Cockroach allergen models

Urban asthma allergen exposure models

Pollen allergen models

Seasonal allergy and asthma research

Genetic Models

Gene targeted models for asthma research:

Th2 cytokine knockouts

Study cytokine contributions to allergic inflammation

Transcription factor models

Investigate transcriptional regulation of allergic responses

Receptor modifications

Study receptor signaling in airway disease

Signaling pathway models

Dissect intracellular pathways driving allergic responses

Lung-Specific Cre Drivers

Cre DriverTarget Cell TypeApplication
CC10-CreClara cellsAirway epithelium studies
SPC-CreType II pneumocytesAlveolar epithelium targeting
α-SMA-CreSmooth muscleAirway smooth muscle function
Tie2-CreEndothelial cellsVascular remodeling studies

Applications

Therapeutic Testing

Evaluate anti inflammatory agents:

Corticosteroid efficacy:Evaluate anti-inflammatory corticosteroid responses
Biologic therapeutics:Test monoclonal antibodies targeting cytokines and receptors
Small molecule inhibitors:Assess novel small molecule drug candidates
Combination therapies:Evaluate multi-target therapeutic approaches

Mechanism Studies

Investigate disease pathways:

Immune cell contributions:Define roles of specific immune populations
Cytokine networks:Map cytokine signaling in allergic inflammation
Airway remodeling mechanisms:Study structural changes in chronic disease
Genetic susceptibility:Investigate genetic risk factors for allergic disease

What Researchers Say

“iTL produced a new conditional mouse model for us and the quality of service was exceptional. The team is extremely knowledgeable and the work was completed at the highest possible standards. My project manager was excellent and always happy to answer technical questions and keep me up to date with progress and potential problems. I would recommend iTL highly and will use them again in the future if I need to generate a new mouse line.”

— Albert Basson, PhD

King's College London

Request Allergy and Asthma Models

Contact us to discuss allergy and asthma mouse models for your research. Our scientific team provides complimentary consultation to help you design the optimal model for your respiratory disease research goals.

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Frequently Asked Questions

Common asthma models include OVA-induced allergic airway inflammation, house dust mite models, and genetic models with conditional deletion of genes in lung epithelial cells, smooth muscle cells, or immune cells. Conditional knockout approaches enable tissue-specific study of asthma mechanisms without systemic effects.

Yes. We can design conditional knockout or knockin models targeting genes involved in airway hyperresponsiveness, mucus production, airway remodeling, or Th2 inflammation. Models can be combined with allergen challenge protocols to study specific asthma phenotypes.

Common lung Cre drivers include CC10-Cre (Clara cells), SPC-Cre (type II pneumocytes), alpha-SMA-Cre (smooth muscle), and Tie2-Cre (endothelial cells). Selection depends on whether you're studying airway epithelium, smooth muscle function, vascular remodeling, or immune cell recruitment.

Allergic sensitization is typically modeled through intranasal or intraperitoneal administration of allergens (OVA, house dust mite extract) with adjuvants, followed by repeated airway challenge. Genetic models can enhance susceptibility by modifying immune or epithelial barrier function.

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