Type 2 Diabetes Mouse Models
Since 1998, ingenious targeting laboratory has generated over 2,500 custom mouse models supporting metabolic disease research, with hundreds of type 2 diabetes models enabling investigation of glucose homeostasis, insulin resistance, and beta cell dysfunction mechanisms. Type 2 diabetes mouse models provide essential platform for identifying therapeutic targets and evaluating interventions addressing pathogenic mechanisms driving progressive metabolic disease.
Type 2 diabetes mouse models enable investigation of multifactorial disease mechanisms underlying impaired glucose tolerance, insulin resistance, and eventual beta cell failure characteristic of human type 2 diabetes. Mouse models permit mechanistic investigation of genetic and environmental contributors to diabetes development with control unavailable in human studies.
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Frequently asked questions
C57BL/6J strain develops robust diet-induced obesity and type 2 diabetes phenotypes with high penetrance and rapid disease onset. BTBR+tf/J strain shows even greater metabolic sensitivity. Strain selection depends on specific research question and pathway investigation focus.
High fat diet feeding typically produces measurable insulin resistance within 4 to 8 weeks and overt glucose intolerance by 12 to 16 weeks. Timeline varies with strain genetics, diet composition, and starting age.
Yes, db/db mice show good pharmacological response to antidiabetic drugs. However, monogenic obesity origins limit relevance to polygenetic human type 2 diabetes. DIO models may better represent human disease polygenic nature.
Glucose tolerance combined with insulin tolerance testing and adiposity assessment provide comprehensive type 2 diabetes phenotyping. Metabolic cage analysis reveals energy expenditure contributions. Islet function assessment reveals beta cell specific defects.
Yes, tissue specific conditional knockouts enable investigation of pathway specific contributions. Liver-specific knockouts reveal hepatic glucose production abnormalities, while muscle-specific knockouts reveal peripheral insulin resistance mechanisms.