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10 Gift Ideas For Your Labmates

Lab Secret Santa

Is your lab ready for the holidays? Maybe you and your labmates have already decorated your spaces with festive ornaments, or even leftover gloves and pipette tips. But chances are, you haven’t finished your holiday shopping yet. It’s not easy coming up with an idea for a gift that one of your labmates might enjoy, […]

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Quick Guide For Adding A Reporter To Your cKO Model

Enhance your model with our TruView technology Conditional knockout models enable more flexibility in experimental design compared with the older strategy of constitutive knockout. That flexibility is accompanied by a few additional requirements when planning how the line will be used, such as the extra element of a tissue-specific Cre line in breeding plans. Another […]

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Meet ingenious Scientist Kristen Coughlin

ingenious Scientist Introduction: Kristen Coughlin

Kristen has been with ingenious since 2004 and has held roles in Sales, Marketing, Business Development and Scientific Project Management. She completed her graduate work in molecular genetics and microbiology at Stony Brook University where she studied viral protein trafficking in host cells. At ingenious, Kristen brings her science and business knowledge together to inform […]

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What Singing Mice Can Tell Us About Conversation

What Singing Mice Can Tell Us About Conversation

A new study may shed light on how the brain processes verbal responses during conversation. Researchers from New York University School of Medicine and The University of Texas at Austin conducted this study by observing back-and-forth verbal communication between Costa Rican singing mice. What’s unique about this species, known as Alston’s singing mice, is that […]

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Meet ingenious Scientist Richard Row

ingenious Scientist Introduction: Richard Row

Richard is a Scientific Strategy Consultant at ingenious. As a graduate student at the University of Washington he used zebrafish as a model organism to investigate embryonic development, and he continued similar research as a postdoc at Stony Brook University before joining ingenious. When he’s not helping scientists evaluate their options for new custom genetically […]

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Meet ingenious Scientist Jennifer Parla

ingenious Scientist Introduction: Jennifer Parla

Jennifer is a Scientific Strategy Consultant at ingenious. She completed her graduate work in molecular biology & biochemistry at Stony Brook University, then studied genetics of psychiatric disorders at Cold Spring Harbor Laboratory for her postdoctoral research. At ingenious, Jennifer helps researchers with design strategies for creating their custom genetically engineered animal models. Sometimes she […]

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Top 6 Blog Posts of 2018 by ingenious Scientists

Top Blog Posts of 2018 by ingenious Scientists

The holidays are over and it’s back to work for everyone. In reflection, 2018 was an amazing year for ingenious and the scientific community. We celebrated our 20th year in business and saw that some of the most exciting research results this year were obtained by studying mouse models. In addition, our scientists wrote several […]

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Humans May Be Immune To CRISPR/Cas9

Humans May Be Immune To CRISPR/Cas9

CRISPR/Cas9, one of the most widely used gene editing tools for studying disease, may have no effect in most humans. Scientists at Charité – Universitätsmedizin Berlin discovered that over 90% of people were immune to the Cas9 protein, which could prevent this technology from successfully altering genetic code. The reason for this may be due […]

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Healthier Mice Born to Fathers Who Exercised

Healthier Mice Born to Fathers Who Exercised

Researchers at The Ohio State University College of Medicine’s Wexner Medical Center discovered that male mice who exercised bore offspring that were healthier. The goal of the study was to examine the role a father’s exercise routine and diet can play in the development of metabolic disorders, such as type 2 diabetes, in his offspring. […]

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Sleeping Beauty Used to Identify Genes Contributing to Type of Liver Cancer

Sleeping Beauty Used to Identify Genes Contributing to Type of Liver Cancer

Researchers from Osaka University have identified genes that play a role in hepatocellular carcinoma (HCC), the most common type of liver cancer. One of the most prominent risk factors for HCC is nonalcoholic fatty liver disease (NAFLD). To better identify the contributing genes involved in cancer onset, researchers utilized Sleeping Beauty transposon mutagenesis, integrating it […]

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Healthy Mice Born from Same-Sex Parents

Healthy Mice Born from Same-Sex Parents

In a study published in Cell Stem Cell, researchers at the Chinese Academy of Sciences successfully bred same-sex mice through gene editing and stem cell techniques. For the first time, pups born from male mice reached full term. However, most of them did not live past two days. In the same study, pups born from […]

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2018 Nobel Prize in Physiology or Medicine

2018 Nobel Prize in Physiology or Medicine

The 2018 Nobel Prize in Physiology or Medicine goes to Dr.’s James P. Allison and Tasuku Honjo for their contribution to cancer therapy. Early treatments focused on surgery, radiation, and/or chemotherapy. With the help of research in mice, Dr.’s Allison and Honjo turned their attention to a different place – the immune system – and […]

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A Conditional Knockout That Took Research Further

conditional knockout model

The Right Myopathy Model After years of work in in vitro systems and cultured cells your research may reach a point where an animal model is required. This major transition requires a new mindset, and consideration of factors that didn’t previously affect experiments. When evaluating genetically modified animal models each stage of their life must […]

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Knockout Mice In The Study Of Human Genetic Disease

genetic disease

Knockout Mice and Their Role in Disease Research Our understanding of human health and disease has been advanced immeasurably by research using knockout mouse models. In the thirty years since targeted gene knockouts were first demonstrated, thousands of these models have been created. For many human genetic diseases a specific gene is found to be […]

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