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Custom Rat Models

CRISPR Rat

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In just three months. Mosaicism eliminated.

Our advanced process enables genome editing directly within the rat’s germline. This allows for consistent and precise targeting, removes concerns and extra breeding due to mosaicism, and achieves germline transmission in three months versus six with traditional approaches.

  • More predictive power
  • Mosaicism eliminated
  • Enhanced speed
Get your custom rat model in less time & with more certainty.

Download Rat Model Technology Guide

What Types of CRISPR Rat Models Are Possible?

The types of custom rat models that we can make for you are rat knockins that include a point mutation knockin, a knockin with reporter, an inducible/reversible knockin, and a Rosa26 rat knockin. Rat knockout models include a constitutive knockout and a conditional knockout.

Rat Point Mutation Knockin
Rat Knockin w/ Reporter
Constitutive Rat Knockout
Rosa26 Rat Knockin
Rat Inducible/Reversible KI
Conditional Rat Knockout

Rat Strains Available

Gene targeting in diverse rat strains, including:

  • Why Rat Models?

    Rats have been used to model human disease for over a century within a broad range of science fields including neurobiology, cardiology, immunology and toxicology. Their size and physiological similarity to humans make them an ideal choice for many labs. For example, surgical manipulations can be performed on rats that are difficult or impossible with smaller rodents, and fewer animals are required to generate sufficient material for experiments. Previously it was difficult to genetically modify rats but these limitations have been overcome by the use of CRISPR technology. Coupling CRISPR with our sperm stem cell technology takes this one step further, alleviating issues of consistency, predictability and mosaicism which are common when using CRISPR in embryos.

  • Resources

    Chapman KM, Medrano GA, Jaichander P, Chaudhary J, Waits AE, Nobrega MA, Hotaling JM, Ober C, Hamra FK. 2015. Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem CellsCell Rep 10(11): 1828-35.