Why Target the Rosa26 Locus?
- Predictable targeting
- Increased accuracy
- Shorter model generation timelines
- Overall lower production costs
- Stable gene expression without perturbing endogenous genes
Rosa26 Mouse Model Types
Constitutive Expression
Continuous expression from Rosa26 or CAG promoter
Tissue-Specific Expression
Expression controlled by tissue-specific Cre lines
Conditional Expression
Inducible expression with Cre or other systems
What is the Rosa26 Locus?
Rosa26 refers to a specific site on mouse chromosome 6. It was identified in a screen designed to find places in the genome where the insertion of foreign DNA would not have unpredictable results.
The Rosa26 locus is a genomic safe harbor—a targeted insertion site for foreign DNA that does not impact the growth, development or fertility of the resulting transgenic mice. This makes it ideal for integrating transgenes for stable expression.
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Rosa26 Resources
Download our free Rapid-Rosa26™ Quick Guide to learn more about our accelerated targeting technology.