Humanized Immune Checkpoint Mice
Humanized immune checkpoint models enable preclinical testing of human specific checkpoint inhibitor antibodies in immunocompetent mice.
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Explore 10,000+ genetically engineered mouse and rat models
Available Checkpoint Models
PD1 Humanized Mice
PDCD1Enables testing of anti PD1 antibodies including pembrolizumab and nivolumab.
Learn morePDL1 Humanized Mice
CD274Enables testing of anti PDL1 antibodies including atezolizumab, durvalumab, and avelumab.
Learn moreLAG3 Humanized Mice
CD223Supports development of anti LAG3 antibodies as single agents and in combination with PD1 blockade.
Learn moreTIM3 Humanized Mice
HAVCR2Enables testing of anti TIM3 antibodies as emerging checkpoint targets.
Learn moreCombination Checkpoint Models
PD1/CTLA4 Double Humanized
Testing combinations similar to nivolumab plus ipilimumab
PD1/LAG3 Double Humanized
Next generation combination therapies
Triple Checkpoint Models
Multi agent regimens testing
Custom Combinations
Tailored to specific immunotherapy programs
Humanization Strategies
Extracellular Domain Humanization
Humanizes the extracellular domain where therapeutic antibodies bind while retaining mouse transmembrane and intracellular domains. Maintains normal signaling while enabling human antibody binding.
Complete Gene Replacement
Complete replacement with the human gene provides a fully humanized target. Preferred when studying antibodies that modulate signaling or when complete humanization is required.
Tumor Model Compatibility
C57BL/6 Background
Compatible lines: MC38 (colon), B16 (melanoma), E0771 (breast), Lewis lung carcinoma
BALB/c Background
Compatible lines: CT26 (colon), 4T1 (breast), Renca (kidney)
What Researchers Say
“iTL produced a new conditional mouse model for us and the quality of service was exceptional. The team is extremely knowledgeable and the work was completed at the highest possible standards. My project manager was excellent and always happy to answer technical questions and keep me up to date with progress and potential problems. I would recommend iTL highly and will use them again in the future if I need to generate a new mouse line.”
— Albert Basson, PhD
King's College London
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