In Vivo Efficacy Studies
Efficacy studies evaluate therapeutic candidates in disease relevant mouse models. ingenious targeting laboratory designs and executes studies using your custom models or established disease models appropriate for your therapeutic target.
Study Design
Rigorous study design is essential for generating reliable preclinical data. Our team works with you to define:
- Appropriate endpoints based on therapeutic hypothesis
- Statistically powered group sizes
- Optimized dosing regimens
- Regulatory aligned analysis plans
Oncology Studies
Tumor efficacy studies evaluate antitumor activity using:
- Syngeneic tumor models
- Xenograft models
- Genetically engineered tumor models
- Tumor volume and survival endpoints
- Correlative biomarker analysis
Disease Model Studies
Therapeutic areas including neuroscience, metabolic disease, immunology, and cardiovascular research benefit from disease specific efficacy models. We design studies with endpoints relevant to your disease area and therapeutic approach.
Phenotyping Services
Phenotyping characterizes your mouse model across multiple parameters to understand the biological consequences of genetic modification. Comprehensive phenotyping informs experimental design and identifies unexpected phenotypes.
Basic Phenotyping
Foundational characterization identifies overt phenotypes and overall health impacts:
- Body Weight Monitoring:Tracks growth curves and identifies developmental abnormalities
- Survival Analysis:Enables Kaplan Meier analysis of lifespan effects
- Gross Anatomy:Necropsy with organ weight measurement
- Clinical Observations:Behavioral changes and neurological signs
Clinical Chemistry and Hematology
Blood based analysis provides insight into:
- Metabolic, hepatic, renal, and hematopoietic function
- Standard panels customized based on research focus
- Blood based insight into model physiology
Histopathology
Tissue collection and histological analysis reveals structural changes at the cellular level. Board certified pathologists provide expert interpretation of findings.
Metabolic
Glucose tolerance testing for metabolic models
Cardiovascular
Echocardiography for cardiac models
Behavioral
Behavioral testing for neuroscience models
Immune
Immune phenotyping for immunology models
Pharmacology Studies
Pharmacology studies evaluate drug pharmacokinetics, pharmacodynamics, and target engagement in your mouse models.
PK Studies
Pharmacokinetic studies determine drug absorption, distribution, metabolism, and excretion. Time course sampling enables characterization of exposure profiles.
PD Studies
Pharmacodynamic studies correlate drug exposure with biological effect. Target engagement, biomarker modulation, and downstream pathway effects demonstrate mechanism of action.
PK/PD Modeling
Integration of pharmacokinetic and pharmacodynamic data enables modeling of exposure response relationships to guide dose selection.
Integrated Preclinical Programs
Model to Data
ingenious targeting laboratory's integrated capabilities enable seamless progression from custom model generation through breeding, cohort development, and preclinical studies. This eliminates the complexity and delays associated with transferring animals between service providers.
Study Coordination
Our project management team coordinates all aspects of preclinical programs, from initial model design through data delivery. Regular updates keep you informed of progress and enable adaptive study design.
Data Delivery
Preclinical study reports include complete methodology, raw data, statistical analysis, and interpretation. Data packages are formatted to support regulatory submissions and publication.
Quality and Compliance
AAALAC Accreditation
ingenious targeting laboratory operates AAALAC accredited facilities meeting the highest standards for animal care and welfare.
Regulatory Alignment
Study designs and documentation are prepared with regulatory requirements in mind, supporting IND enabling studies and other regulatory submissions.
What Researchers Say
“The Hephaestin flox model ingenious has made for us has been great. It has helped generate eight research publications.”
— Joshua Dunaief, PhD, MD
University of Pennsylvania
Start Your Project
Ready to discuss preclinical services for your program? Our scientific team provides complimentary consultation to help you design an integrated approach from model generation through preclinical data.
Frequently Asked Questions
Preclinical Services Insights
Expert research insights delivered biweekly. Written by PhD scientists, designed for researchers who need cutting-edge knowledge to advance their projects.