Rabbits have a unique advantage as animal models for biomedical research. Adult rabbits are closer in weight and size to humans than are smaller animals, allowing technology and equipment developed for humans to be easily tested. Because of the anatomical, physiological, genetic and biochemical similarities between the rabbit and the human, this species is preferentially used in pulmonary, cardiovascular and metabolic studies.
ingenious has partnered with leading researchers to develop CRISPR technology for creating custom rabbit models. With these advanced technological capabilities, ingenious rabbit models strive to address the needs of drug discovery and drive progress in disease research.
Rabbits have a gestation period of 30-31 days, large litter sizes of 4-12 kits per litter, and can be housed conveniently in an indoor facility. Compared to mice, rabbits are phylogenetically closer to humans.
A major bottleneck in researching human disease and developing new drugs is the lack of large animal models that more accurately simulate human disease in the pre-clinical setting. For example, although the study of the cardiovascular system has benefited significantly from the use of mouse models, small rodents do not always reflect human cardiovascular physiology.
To generate more useful animal models for better mimicking the human system, ingenious now offers rabbit models for disease exploration. Rabbits are good models for disease research because their systems are similar to those of humans. However, the use of rabbits has been hindered by a lack of availability of embryonic stem cell lines for gene manipulation. With the use of CRISPR technology, as with CRISPR mice, creating gene targeted rabbits is now easier, and ingenious offers a streamlined service to make it easy.
The process starts with evaluating your target gene for CRISPR knockout or knockin design feasibility, and then carrying out the rabbit model production process. From project initiation to founder or germline transmission rabbits, the timeline is estimated to be about 12 months. To get started with discussing your custom rabbit model project with us, submit your quote request using the button below.
1) Niimi M, Yang D, Kitajima S, Ning B, Wang C, Li S, Liu E, Zhang J, Eugene Chen Y, Fan J. 2016. ApoE knockout rabbits: A novel model for the study of human hyperlipidemia. Atherosclerosis 245: 187-93.
2) Song J, Yang D, Ruan J, Zhang J, Chen YE, Xu J. 2017. Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting. Sci Rep 7(1):12202.