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Humanized Mice

Why Make A Humanized Mouse?

Why Make A Humanized Mouse?

Humanized Mouse Models The mouse has been used for over 30 years as a model system for studying human disease. Recently, “humanized” mice have grown in popularity because they are formidable models of the human being and therefore extremely useful for understanding the human condition. What exactly is a humanized mouse? A humanized mouse is a […]

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Humanized Mouse Model

Humanized Mouse Model

Can a Common Humanized Mouse Model Solve Immunotherapy Related Problems? If you are aware of how important a humanized mouse model can be in fields like cancer study and HIV research, you probably already know about other contributions. Humanized mice serve to offer researchers a great deal of help when it comes to dealing with […]

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Expand the Possibilities of Humanized Models

humanized models

…Beyond the Coding Sequence. Human genetic sequences have been routinely inserted into the mouse genome since the early 1980s when reliable methods were first developed. These genetically humanized models were quickly recognized as a means to study human diseases or produce specific valuable human proteins. Recent method development has expanded the possibilities for genetic humanization and […]

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Humanization of Larger Animal Models

humanization

Humanization of Custom Rabbit Models A major bottleneck in researching human disease and developing new drugs is the lack of larger animal models that more accurately simulate human disease in the pre-clinical setting. The advantages of developing better models for human biology become clearer every day, especially including improved chances of translating research from animal […]

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A New Humanized Mouse Model

A New Humanized Mouse Model

A New Humanized Mouse Model Leads to New Opportunities in Treating Colorectal Cancer While immunotherapy is effective in the case of many different types of cancer, colorectal cancers have always presented scientists with far greater challenges, due to being “microsatellite stable.” According to Julie Lang, PhD, the CU Cancer Center’s senior research associate, a new […]

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Humanized Mice Used In Newborn Jaundice Research

Advanced Treatments Aiming to Stop the Development of Newborn Jaundice A condition known as jaundice is responsible for many health risks and problems involving newborn babies, particularly in lesser developed countries throughout Africa and South Asia, where treatments such as blood transfusions are not as readily available as in developed countries. Newborn jaundice is caused […]

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Humanized Mouse Assists Cytokines Therapy

Humanized Mouse in FA Research

New Friedreich’s Ataxia Humanized Mouse Model Study Assists Cytokines Therapy A new study has recently appeared in Annals of Neurology, showing how neuroprotective results were obtained in a Friedreich’s Ataxia (FA) model. The mouse model in question was treated with clinically approved cytokines used for other diseases, and the results showed that future research using […]

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ZIKV Mouse Model 

ZIKV Mouse Model

Studying the Zika Virus with a New ZIKV Mouse Model The Zika virus, also known as ZIKV, has become notorious in Brazil, where it had spread during 2015, infecting thousands of people. The main risk of the virus is in its association with the Cuillain-Barre Syndrome, a rare autoimmune disease that can cause microencephaly in […]

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