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Humanized Immune Checkpoint Mice
Humanized immune checkpoint models enable preclinical testing of human specific checkpoint inhibitor antibodies in immunocompetent mice.
Single Checkpoint Models
Individual checkpoint humanizations available include:
- PD1 Humanized: Human PDCD1 extracellular domain for anti PD1 antibody testing
- PDL1 Humanized: Human CD274 extracellular domain for anti PDL1 antibody testing
- CTLA4 Humanized: Human CTLA4 extracellular domain for anti CTLA4 antibody testing
- LAG3 Humanized: Human LAG3 extracellular domain for anti LAG3 antibody testing
- TIM3 Humanized: Human HAVCR2 extracellular domain for anti TIM3 antibody testing
Double Checkpoint Models
Combination checkpoint humanizations enable testing of dual checkpoint blockade approaches:
- PD1/CTLA4 Double Humanized: For combination anti PD1 plus anti CTLA4 studies
- PD1/LAG3 Double Humanized: For combination anti PD1 plus anti LAG3 studies
- PD1/TIM3 Double Humanized: For combination anti PD1 plus anti TIM3 studies
Cre Driver Lines
Cre driver lines express Cre recombinase in specific tissues or under inducible control. Crossing Cre drivers with floxed alleles enables tissue specific or temporally controlled gene deletion.
Tissue Specific Cre Lines
Constitutive Cre drivers express Cre recombinase under tissue specific promoters. Available lines include drivers for liver, kidney, heart, brain, immune cells, and other tissues.
Inducible Cre Lines
Tamoxifen inducible CreERT2 and doxycycline inducible rtTA Cre systems enable temporal control over Cre activity. These lines are available with various tissue specific or ubiquitous promoters.
Reporter Lines
Reporter mice express fluorescent proteins, enzymatic markers, or other reporters under various promoter systems. These strains enable cell tracking, lineage tracing, and visualization of gene expression.
Constitutive Reporters
Ubiquitous reporter expression enables cell labeling and tracking applications.
Cre Dependent Reporters
Cre dependent reporters are activated only in cells expressing Cre recombinase, enabling fate mapping and lineage tracing when combined with tissue specific Cre drivers.
Inducible Reporters
Inducible reporter systems enable temporally controlled labeling for pulse chase experiments and acute lineage tracing.
Ordering Information
Availability
Catalog models are maintained as breeding colonies or cryopreserved stocks. Contact us to confirm current availability and estimated ship dates.
Shipping
Models are shipped as breeding pairs or cohorts depending on your requirements. Domestic and international shipping are available with appropriate documentation.
Documentation
All catalog models include genotyping protocols, strain background information, and health documentation.
Material Transfer
Standard material transfer agreements govern use of catalog models. Contact us to discuss licensing terms for commercial and academic applications.
Order Inquiry
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