"A better model is within reach."

Green Tea And Carrot Compounds Improved Cognition In Mouse Models Of AD

Green Tea And Carrot Compounds Improved Cognition In Mouse Models Of AD

Mouse models of Alzheimer’s disease experienced improved working memory after medical scientists fed them a diet of compounds found in green tea and carrots. The team of researchers from the University of Southern California looked to test how two compounds, epigallocatechin-3-gallate (EGCG) and ferulic acid, would work together, as they both showed signs of alleviating […]

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What Singing Mice Can Tell Us About Conversation

What Singing Mice Can Tell Us About Conversation

A new study may shed light on how the brain processes verbal responses during conversation. Researchers from New York University School of Medicine and The University of Texas at Austin conducted this study by observing back-and-forth verbal communication between Costa Rican singing mice. What’s unique about this species, known as Alston’s singing mice, is that […]

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Meet ingenious Scientist Richard Row

ingenious Scientist Introduction: Richard Row

Richard is a Scientific Strategy Consultant at ingenious. As a graduate student at the University of Washington he used zebrafish as a model organism to investigate embryonic development, and he continued similar research as a postdoc at Stony Brook University before joining ingenious. When he’s not helping scientists evaluate their options for new custom genetically […]

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Excitation-Inhibition Balance Theory Of Autism Examined In Mouse Models

Excitation-Inhibition Balance Theory Of Autism Examined In Mouse Models

By studying four mouse models of autism, researchers at the University of California, Berkeley discovered that altering the balance of excitation and inhibition of neurons in the brain does not affect hyperexcitability, also known as “spiking,” challenging a popular theory in the field. The excitation-inhibition balance theory proposes that spiking should decrease when inhibition increases, […]

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Monthly Animal Model Roundup: February

Monthly Animal Model Roundup February

Every month, the ingenious team reviews some of the most exciting new research using mouse, rat, and rabbit models. Here are the top stories for February, all in one place for your convenience. The Relationship Between Alzheimer’s And Gum Disease Using mice, researchers at the University of Louisville have identified a connection between Alzheimer’s and […]

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Effects Of Climate Change In Mouse Models With Influenza Virus

Effects Of Climate Change In Mouse Models With Influenza Virus

It is predicted that climate change will reduce crop yields and the nutritional value in food over time, as well as increase the infection range of insects that spread disease. However, how heat waves affect the immune system when exposed to common viruses has not been studied before. To investigate this further, scientists at the […]

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CL

The Cre-lox system is an incredibly powerful and versatile tool for scientists who use mice in their research. The method has many advantages including over two decades of proven success in mouse models and the ability to enable otherwise-impossible experiments. A common application of Cre-lox in mice is the conditional knockout model which is a […]

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Meet ingenious Scientist Jennifer Parla

ingenious Scientist Introduction: Jennifer Parla

Jennifer is a Scientific Strategy Consultant at ingenious. She completed her graduate work in molecular biology & biochemistry at Stony Brook University, then studied genetics of psychiatric disorders at Cold Spring Harbor Laboratory for her postdoctoral research. At ingenious, Jennifer helps researchers with design strategies for creating their custom genetically engineered animal models. Sometimes she […]

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New Cre-lox Design Guide For Conditional Knockout Mouse Models

New Cre-Lox Design Guide For Conditional Knockout Mouse Models

We’ve compiled a short guide to choosing a strategy for your next conditional knockout (cKO) model which you can download here. Compared with standard knockout models a cKO has much greater flexibility, for example by enabling tissue-specific knockout of your target gene. As with any genetic modification the right design is crucial and must be […]

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Cre Flox

The Cre-Lox System and What Floxed Mice Are Actually All About Whether you’re just starting out in genetic research, or you’ve already been studying it for several years, you’re probably already familiar with floxed mice. As many seasoned experts will tell you, floxing is an extremely useful and powerful process by which the Cre-lox system […]

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Floxed Mice

Floxed Mice and the Process of Obtaining Inverted, Translocated and Tissue-Specific Knockouts The Cre-lox recombination process and the floxing method have become an effective technique to use in order to obtain knockout mice. Whether researchers are looking to find the effects that the inactivation of a certain gene has on cancer cells, or whether they’re […]

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Flox

How to Obtain a Conditional Knockout – Floxed Mice and the Cre-Lox Procedure Conditional knockouts have become extremely useful in recent years. Having helped researchers find out the reasons behind countless ailments and some of the rarest and most dangerous genetic diseases in humans, genetic research has come a long way in the past 20 […]

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Floxed Gene

Cre-Lox Technology and the Helpful Development of Flox Genes and Mice Before understanding why flox mice are so important, it is necessary to take a closer look at the complex process that makes their existence possible: the Cre-lox recombination system. This system is responsible for developing flox mice in a fraction of the time that […]

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TLR4 Floxed Mice

The Practical Importance of TLR4 Floxed Mice in Preventing Immune System Disorders Genetically modified mice in general, and floxed mice in particular, have played a significant role in helping scientists better understand and protect the human body’s immune system. Due to the fact that mice have a similar genome to that of humans, researchers have […]

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P53 Flox Flox

P53 Floxing and the Important Research of Studying Cancer Treatments Also known as the tumor protein or even nicknamed the “guardian of the genome,” p53 is one of the most essential proteins in the body. It is actually the isoform of a protein that is responsible for regulating cell growth and preventing the formation of […]

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