"A better model is within reach."

Quick Guide For Adding A Reporter To Your cKO Model

Enhance your model with our TruView technology Conditional knockout models enable more flexibility in experimental design compared with the older strategy of constitutive knockout. That flexibility is accompanied by a few additional requirements when planning how the line will be used, such as the extra element of a tissue-specific Cre line in breeding plans. Another […]

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Why Should You Consider Working With Transgenic Mice?

A Custom Transgenic Mouse Can Fit Your Research Goals Transgenic mice are genetically modified animals with an extra genetic sequence, called a transgene, permanently integrated into their genome. This type of genetically modified mouse model can be used for a wide variety of different studies because the sequence of the transgene is under the researcher’s […]

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P53 Floxed Mice

The Study of Cancer and Tumor Suppression Through p53 Floxed Mice P53 floxed mice and knockout mice are used for the study of tumor suppression mechanisms and what happens when they fail. While the human body is extremely complex and intelligent, the impairment of a “tiny” tumor suppressing gene like the p53 gene – as […]

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Lox Knockout

The Practical Process of Obtaining a Lox Knockout with the Cre-Lox System A Lox knockout obtained using the Cre-lox recombination system is simply the process of generating a gene knockout using floxed mice of a specifically targeted gene, then splicing and deleting that gene in the Cre/lox mice. For someone who is still new to […]

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Floxing A Gene

From Floxing a Gene to Curing a Disease – The In Vivo Study of Gene Function Most genetic researchers consider that floxing a gene to generate a knockout model of a certain gene, particularly when using mice with mutations for the task, to be an extremely important procedure when it comes to studying the function […]

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ATG5 Flox Mice

Studying the Role of Autophagy in ATG5 Flox Mice There has been a great increase in the study of ATG5 flox mice in order to achieve a better understanding of autophagy and the processes associated with it. The ATG5 protein is a well-known piece of genetic material encoded by the ATG5 gene, which facilitates programmed […]

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Floxed Mice CRE

The Importance of Floxed Mice – Cre Lox Recombination and Conditional Gene Targeting When it comes to understanding the significance of floxed mice, Cre lox recombination and similar methods for gene targeting are essential. This technique was created as a type of site-specific recombination process in order to delete or activate loxP-flanked DNA sequences. It […]

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Flox Sequence

The Process of Creating a Flox Sequence and Its Usefulness in Genetic Manipulation In genetic research, many scientists will mention terms like “gene recombination” and “flox sequence,” which might sound simple, but are actually extremely significant and carry a lot of weight in the field. Flox sequences, for instance, are DNA sequences that are flanked […]

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Rabbit Models of Endocarditis

Rabbit Models of Endocarditis

Infective endocarditis (IE) is a life-threatening disease caused by bacteria that enter the bloodstream and settle in the heart lining, a heart valve, or a blood vessel. If not treated quickly, IE can damage or destroy the heart valves. The heart valves are not supplied directly with blood, which means the body’s immune system cannot […]

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Knockin Mice Used To Discover Cause Of Mitral Valve Prolapse

Knockin Mice Used To Discover Cause Of Mitral Valve Prolapse

A new mouse model of mitral valve prolapse, a common heart disease, was used to find a potential cause for this disease in humans. Characterized by a “clicking” sound in the chest and regurgitation of blood in the left atrium of the heart, this heart complication previously did not have any known causes. Scientists at […]

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Bladder Drug May Increase Effects Of Atherosclerosis In Mice

Bladder Drug May Increase Effects Of Atherosclerosis In Mice

Mouse models were used to discover that mirabegron, a popular drug for the treatment of overactive bladder, may increase the likelihood of blocked arteries, cardiovascular disease, and stroke in patients with atherosclerosis. The mice for this study contained mutations in the ApoE gene or in the low density lipoprotein (LDL) receptor to mimic different forms […]

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Light Flickers Shown to Help Mouse Models of Alzheimer’s Disease

Light Flickers Shown To Help Mouse Models Of Alzheimers Disease

Researchers at MIT have published exciting new data on a potential treatment to reduce the severity of Alzheimer’s disease (AD), as seen in mouse models. They previously found that physical signs of AD, such as protein plaques in the brain, could be reduced by a regimen of light therapy. The treatment requires only exposure to […]

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Rat Models of Spinal Cord Injury

Rat Models of Spinal Cord Injury

Spinal Cord Injury, or SCI, results from physical trauma to the spinal cord or from medical illness that injures or damages the spinal cord. The spinal cord is a major bundle of nerves that extends from the base of the brain and down the middle of the back, to about the waist. It transmits nerve […]

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Floxing

What Is Gene Floxing and Why Is It Used so Frequently by Scientists Today? Floxing, or flanking by loxP, is a process used by geneticists by which a specifically targeted gene is flanked by two loxP sites. Although seemingly simple, this process is relatively new and quite complex, potentially leading to extremely important and far-reaching […]

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