"A better model is within reach."

10 Gift Ideas For Your Labmates

Lab Secret Santa

Is your lab ready for the holidays? Maybe you and your labmates have already decorated your spaces with festive ornaments, or even leftover gloves and pipette tips. But chances are, you haven’t finished your holiday shopping yet. It’s not easy coming up with an idea for a gift that one of your labmates might enjoy, […]

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Types Of Custom Mouse Models

Types Of Custom Mouse Models

Not sure which mouse model you might need for your next study? Whether you’ve made mouse models before or you’re about to create your first one, the experts here at ingenious targeting laboratory have put together this helpful guide for your reference. Ready to get started? Get a custom quote from one of our scientific […]

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A Need For Careful Screening In The Development Of CRISPR/Cas Lines

A Need for Careful Screening in the Development of CRISPR Cas Lines

What You Should Know from a Breeding and Genotyping Standpoint Standard applications of CRISPR/Cas9 as a genome editing tool aim to generate relatively small (up to several kb) targeted genetic mutations in the form of insertions, replacements, or deletions. Successful outcomes require both careful design of the genetic strategy and downstream screening efforts during subsequent […]

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What Lab Instrument Are You?

What Lab Instrument Are You?

You use a lot of equipment as a researcher, but does your favorite lab instrument best fit your personality style? Take ingenious targeting laboratory‘s quiz to find out!

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Client Success With Knockin Mouse Model

Point Mutation Knockin Mouse Model Brings Client Success

Point Mutation Knockin Mouse Model Brings Client Success Dr. Virginia Kimonis started her career as a pediatrician in the UK and United Arab Emirates, where she encountered a number of patients with rare genetic diseases. These experiences motivated her to pursue training as a clinical geneticist at the National Institutes of Health. She also trained […]

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APC Flox Mice

Studying APC Flox Mice and The Possible Treatment of Familial Adenomatous Polyposis APC flox mice have been the recent focus in research on the possible treatment of conditions such as familial adenomatous polyposis (FAP) and similar disorders that can lead to colon cancer. Colon cancer is among the top most problematic and widespread forms of […]

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Flox Design

Unique Flox Design Made Easy – Producing Conditional Knockout Mouse Models Without Any Complications Creating the ideal flox design for your project can be a difficult task depending on what the end goal might be. Generating conditional knockout mouse models requires a certain degree of precision and thorough research regarding the gene that has to […]

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CRE Floxed Mice

How the Use of Cre Floxed Mice Has Changed the Face of Genetic Research If you study genetics, you’re probably already familiar with Cre floxed mice and their remarkable contributions to genetic research. These types of mice are responsible for the study of genes that, if mutated or inactivated, can lead to severe physiological changes […]

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Quick Guide For Adding A Reporter To Your cKO Model

Enhance your model with our TruView technology Conditional knockout models enable more flexibility in experimental design compared with the older strategy of constitutive knockout. That flexibility is accompanied by a few additional requirements when planning how the line will be used, such as the extra element of a tissue-specific Cre line in breeding plans. Another […]

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Why Should You Consider Working With Transgenic Mice?

A Custom Transgenic Mouse Can Fit Your Research Goals Transgenic mice are genetically modified animals with an extra genetic sequence, called a transgene, permanently integrated into their genome. This type of genetically modified mouse model can be used for a wide variety of different studies because the sequence of the transgene is under the researcher’s […]

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P53 Floxed Mice

The Study of Cancer and Tumor Suppression Through p53 Floxed Mice P53 floxed mice and knockout mice are used for the study of tumor suppression mechanisms and what happens when they fail. While the human body is extremely complex and intelligent, the impairment of a “tiny” tumor suppressing gene like the p53 gene – as […]

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Lox Knockout

The Practical Process of Obtaining a Lox Knockout with the Cre-Lox System A Lox knockout obtained using the Cre-lox recombination system is simply the process of generating a gene knockout using floxed mice of a specifically targeted gene, then splicing and deleting that gene in the Cre/lox mice. For someone who is still new to […]

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Floxing A Gene

From Floxing a Gene to Curing a Disease – The In Vivo Study of Gene Function Most genetic researchers consider that floxing a gene to generate a knockout model of a certain gene, particularly when using mice with mutations for the task, to be an extremely important procedure when it comes to studying the function […]

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ATG5 Flox Mice

Studying the Role of Autophagy in ATG5 Flox Mice There has been a great increase in the study of ATG5 flox mice in order to achieve a better understanding of autophagy and the processes associated with it. The ATG5 protein is a well-known piece of genetic material encoded by the ATG5 gene, which facilitates programmed […]

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