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How to Make a Transgenic Mouse

How to Make a Transgenic Mouse and What Technologies Can Be Used? Understanding how to make a transgenic mouse is important for a number of reasons that are relevant to the direction that genetic research has taken. Transgenic mice – primarily in the form of knockout mice – are an integral part of the research of diseases such as obesity, heart
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Making Knockout Mice

The Process of Making Knockout Mice: Essential Steps and Recommendations Making knockout mice might be a complicated process overall, and the rate of success that researchers can expect is far from 100%, even with the most advanced tools and methods. However, the concept behind the creation of knockout transgenic mouse models is not too difficult to understand. Considering the remarkable usefulness
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Gene Targeting

Understanding Gene Targeting and Its Practical Applications in Genetics Scientists and students interested in gene targeting are at the forefront of one of the most advanced and exciting research area in human history. The ability to alter specific genes and replace them through homologous recombination has been perfected recently, but it is based on studies dating back to Sternberg and Hamilton’s
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Gene Knockout

Gene Knockout and Its Essential Role Played in the Fight Against Human Disease The gene knockout process is one of the most important genetic techniques used for altering the genetic makeup of mammalian creatures. Typically used on mice, it involves a number of complex processes and methods that can be used for facilitating the inactivation of a gene. Whether we’re talking
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Gene Knockout Mice

Obtaining the Perfect Gene Knockout – Mice and Their Role in Genetics When using the right technology and methods to obtain a gene knockout, mice are found to be the best tool we can utilize. Mice are easy to work with, their lifespans allow for convenient long term experimentation, and their genome is close enough to the human genome to allow
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Why Make A Humanized Mouse?

Why Make A Humanized Mouse?

By Kristen Coughlin Humanized Mouse Models The mouse has been used for over 30 years as a model system for studying human disease.  Recently, “humanized” mice have grown in popularity because they are formidable models of the human being and therefore extremely useful for understanding the human condition.  What exactly is a humanized mouse? A humanized mouse is a mouse that
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