"A better model is within reach."

Novel Transgenic Rat Model Of Cerebral Amyloid Angiopathy

Novel Transgenic Rat Model Of Cerebral Amyloid Angiopathy

According to a new study in The American Journal of Pathology, researchers have generated a novel transgenic rat model (rTg-DI) of cerebral amyloid angiopathy (CAA). This condition is often observed in older individuals afflicted by Alzheimer’s disease and dementia. To date, animal models of CAA have been lacking and results from available mouse models have […]

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Humans May Be Immune To CRISPR/Cas9

Humans May Be Immune To CRISPR/Cas9

CRISPR/Cas9, one of the most widely used gene editing tools for studying disease, may have no effect in most humans. Scientists at Charité – Universitätsmedizin Berlin discovered that over 90% of people were immune to the Cas9 protein, which could prevent this technology from successfully altering genetic code. The reason for this may be due […]

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Healthier Mice Born to Fathers Who Exercised

Healthier Mice Born to Fathers Who Exercised

Researchers at The Ohio State University College of Medicine’s Wexner Medical Center discovered that male mice who exercised bore offspring that were healthier. The goal of the study was to examine the role a father’s exercise routine and diet can play in the development of metabolic disorders, such as type 2 diabetes, in his offspring. […]

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What Is A Knockout Rat

What Is a Knockout Rat and What Is Its Main Purpose? What is a knockout rat, and what makes these animals such an important tool for examining the human genome? In the field of genetic study and drug development, the need for a better understanding and a deeper influence of knockout genes in complex organisms […]

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Transgenic Rats vs Mice

The Basics of Transgenic Rats vs Mice in Genetic Research and Engineering The use of transgenic rats vs mice to facilitate genetic research has been an important choice that researchers have needed to consider since the first transgenic rats were developed. Before that, laboratory mice and their use in embryonic stem cell studies dominated the […]

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Transgenic Rat Service

The Many Advantages of Using a Transgenic Rat Service for Genetic Research Transgenic rat services have become extremely prominent in recent years as a result of the rapid growth in the development of technology used for genetically altering animal models. Genetic manipulation in rats has considerably improved over the past five years. As a result, […]

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Transgenic Rat Models

Using Transgenic Rat Models to Transcend the Limitations of Neurological Studies Transgenic rat models are helpful in a variety of research areas. From the development of knockin rat models that facilitate the study of a specific gene to knockout rats designed to help find treatments for genetic disorders, transgenic rats have many potential uses. Many […]

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Rat Models

The Increasingly Important Use of Rodents and Rat Models in Genetic Experiments Genetic scientists across the entire world agree that the use rat models for genetic research and experimentation have become much more important than it was in past years. While species such as saccharomyces cerevisiae, fruit flies, and zebrafish have been used for the […]

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Knockout Rat Models

What Are Knockout Rat Models and Why Are They Needed? With the use of knockout rat models, genetic researchers are able to gather important information about the rat genome and the roles those genes play, not only in regulating physiological processes throughout the body, but also in inducing or eliminating certain disorders. The genetic origins […]

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Knockin Rats

Genetic Research in the Modern Age: How Are Knockin Rats Prepared? Knockin rats have become an essential tool for scientists and genetic research experts to discover new treatments, solutions, and breakthroughs for debilitating human diseases. So how are knockin rat models created, and how do they differ from knockin mice? Although the basic principle is […]

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Genetic Knockout Rats

The Technologies and Approaches Used in Developing Genetic Knockout Rats Rattus norvegicus, also known as the most common species of laboratory rat, has become the an important specimen for genetic research. With advancements in genetic technology, developing genetic knockout rats has become increasingly easier. Researchers are now able to use multiple technologies and methods for […]

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Conditional Knockout Rat

Obtaining More Accurate Results with Conditional Knockout Rat Models While the knockout mouse has received much attention for its contribution to a large body of genetic research, the conditional knockout rat has been gaining a lot of ground as well. Even though they are similar to mice, knockout rats are meant for experiments that examine […]

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Sleeping Beauty Used to Identify Genes Contributing to Type of Liver Cancer

Sleeping Beauty Used to Identify Genes Contributing to Type of Liver Cancer

Researchers from Osaka University have identified genes that play a role in hepatocellular carcinoma (HCC), the most common type of liver cancer. One of the most prominent risk factors for HCC is nonalcoholic fatty liver disease (NAFLD). To better identify the contributing genes involved in cancer onset, researchers utilized Sleeping Beauty transposon mutagenesis, integrating it […]

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Healthy Mice Born from Same-Sex Parents

Healthy Mice Born from Same-Sex Parents

In a study published in Cell Stem Cell, researchers at the Chinese Academy of Sciences successfully bred same-sex mice through gene editing and stem cell techniques. For the first time, pups born from male mice reached full term. However, most of them did not live past two days. In the same study, pups born from […]

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2018 Nobel Prize in Physiology or Medicine

2018 Nobel Prize in Physiology or Medicine

The 2018 Nobel Prize in Physiology or Medicine goes to Dr.’s James P. Allison and Tasuku Honjo for their contribution to cancer therapy. Early treatments focused on surgery, radiation, and/or chemotherapy. With the help of research in mice, Dr.’s Allison and Honjo turned their attention to a different place – the immune system – and […]

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