"A better model is within reach."

Bladder Drug May Increase Effects Of Atherosclerosis In Mice

Bladder Drug May Increase Effects Of Atherosclerosis In Mice

Mouse models were used to discover that mirabegron, a popular drug for the treatment of overactive bladder, may increase the likelihood of blocked arteries, cardiovascular disease, and stroke in patients with atherosclerosis. The mice for this study contained mutations in the ApoE gene or in the low density lipoprotein (LDL) receptor to mimic different forms […]

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Light Flickers Shown to Help Mouse Models of Alzheimer’s Disease

Light Flickers Shown To Help Mouse Models Of Alzheimers Disease

Researchers at MIT have published exciting new data on a potential treatment to reduce the severity of Alzheimer’s disease (AD), as seen in mouse models. They previously found that physical signs of AD, such as protein plaques in the brain, could be reduced by a regimen of light therapy. The treatment requires only exposure to […]

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Rat Models of Spinal Cord Injury

Rat Models of Spinal Cord Injury

Spinal Cord Injury, or SCI, results from physical trauma to the spinal cord or from medical illness that injures or damages the spinal cord. The spinal cord is a major bundle of nerves that extends from the base of the brain and down the middle of the back, to about the waist. It transmits nerve […]

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Floxing

What Is Gene Floxing and Why Is It Used so Frequently by Scientists Today? Floxing, or flanking by loxP, is a process used by geneticists by which a specifically targeted gene is flanked by two loxP sites. Although seemingly simple, this process is relatively new and quite complex, potentially leading to extremely important and far-reaching […]

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Cre Recombinase

The Essential Use of Cre Recombinase in the Creation of Floxed Mice The creation of floxed mice can help geneticists and experts in genetic diseases to study highly specific occurrences of the diseases and how they progress over time. “Floxing” is the action of flanking a gene using two separate loxP sites, and its name […]

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Floxed Allele

Important Facts about the Producing a Floxed Allele to Create Complete Knockouts An allele is essentially a version of a given gene. While some genes are only present once in the body, depending on the species and the particular gene in question, others have two or more alleles of the same gene that result in […]

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Floxed Mouse Model

The Importance of Floxing and How the Use of Floxed Mouse Models Has Advanced The method known as “floxing” is heavily used in today’s genetic research. While scientists have not yet managed to reach its full potential, they are finding remarkable results in discovering how the mouse genome works, and subsequently making many new discoveries […]

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Monthly Animal Model Roundup: April

Monthly Animal Model Roundup: April

This month, animal models have helped make amazing discoveries in new published studies. We’ve summarized some of the top stories for you to read all in one place. Depression, Obesity, And Chronic Pain Relieved In Mice By Targeting Linked Protein Scientists have previously established that depression, obesity, and chronic pain all have a connection through […]

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Common Food Additive May Weaken Flu Vaccine, As Seen In Mouse Models

Common Food Additive May Weaken Flu Vaccine, As Seen In Mouse Models

Researchers at Michigan State University have discovered that a widely-used additive found in crackers, frozen meat, and other foods, suppressed the immune system’s ability to fight the flu in mouse models. The additive, known as tert-butylhydroquinone (tBHQ), may also render the flu vaccine less effective, which was demonstrated by the effects it can have on […]

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Mouse Models Demonstrate Connection Between Gut Microbiome And Cancer Prevention

Mouse Models Demonstrate Connection Between Gut Microbiome And Cancer Prevention

Using mouse models, a team led by researchers from Sanford Burnham Prebys Medical Discovery Institute has demonstrated a connection between the gut microbiome and the immune system’s response to cancer. They studied mice that lacked the RING finger protein 5 (RNF5) ubiquitin ligase, which functions as part of the unfolded protein response (UPR). While the […]

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Meet ingenious Scientist Kristen Coughlin

ingenious Scientist Introduction: Kristen Coughlin

Kristen has been with ingenious since 2004 and has held roles in Sales, Marketing, Business Development and Scientific Project Management. She completed her graduate work in molecular genetics and microbiology at Stony Brook University where she studied viral protein trafficking in host cells. At ingenious, Kristen brings her science and business knowledge together to inform […]

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New Frontiers for Rat Models of Cerebral Palsy

New Frontiers for Rat Models of Cerebral Palsy

The term “cerebral palsy” denotes a highly variable syndrome affecting up to 3 out of every 1000 children born. It’s characterized primarily by motor impairment, but there are also a range of accompanying conditions such as seizure disorders and cognitive defects. Cerebral palsy results from damage to the brain in utero or during the first […]

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Monthly Animal Model Roundup: March

Monthly Animal Model Roundup: March

This past month, there have been so many notable new studies with animal models that it’s difficult to keep track of them all. That’s why the ingenious team put together this summary of some of the top stories for March. Mice Gain “Night Vision” From Nanotech Injections Mammals are unable to see infrared light, but […]

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Green Tea And Carrot Compounds Improved Cognition In Mouse Models Of AD

Green Tea And Carrot Compounds Improved Cognition In Mouse Models Of AD

Mouse models of Alzheimer’s disease experienced improved working memory after medical scientists fed them a diet of compounds found in green tea and carrots. The team of researchers from the University of Southern California looked to test how two compounds, epigallocatechin-3-gallate (EGCG) and ferulic acid, would work together, as they both showed signs of alleviating […]

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