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Press Release: ingenious and SMOC Announce New Partnership to Distribute Catalog Humanized Mouse Models

ingenious and SMOC Announce New Partnership to Distribute Catalog Humanized Mouse Models

INGENIOUS TARGETING LABORATORY AND SMOC SIGN AGREEMENT TO PRODUCE AND DISTRIBUTE CATALOG MOUSE MODELS Ronkonkoma, New York and Shanghai, China — April 14, 2021 – ingenious targeting laboratory, a leading provider of custom animal models for in vivo studies, and Shanghai Model Organisms Center, “SMOC,” a major supplier of laboratory rodents and services, announced a […]

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How A Knockout Mouse Is Made

How A Knockout Mouse Is Made by INGENIOUS

How a Knockout Mouse is Made – Types of Methods and Procedures Understanding how a knockout mouse is made is essential for anyone who works with lab animals. In recent years, with advancements in technology and the development of more advanced methods, the science has become available for transgenic facilities to streamline the knockout mouse […]

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BAC Transgenic

BAC Transgenic

An Overview of BAC Transgenic Mice – BAC Constructs and Their Uses BAC transgenic mice are an invaluable tool for preclinical research as demonstrated by decades of use across many human disease areas. Understanding the potential of these mouse models can help you choose the right one for your next research project. So let’s take […]

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Humanized Mice

Humanized Mice

This content is available for informational purposes, intended for those who are interested in working with mouse models to further their research. Humanized Mice: Use Cases for Studying Human Immunity With the advancement of modern techniques and technologies used for genetic manipulation, humanized mice have become an important asset in the field of genetic research. […]

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Transgenic Mice

What Are Transgenic Mice? An Introduction to Transgenic Mouse Models and Their Role in Genetic Research Let’s start at the beginning: what are transgenic mice? The short answer is that they’re mice that have been artificially modified at a genetic level to include a foreign sequence, or transgene. This often involves the insertion of a […]

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Floxed Allele

Producing a Floxed Allele to Create Knockout Mice

Facts about Producing a Floxed Allele to Create Complete Knockouts An allele is an alternative form of a specific gene. While some genes are only present once in the body, depending on the species and the particular gene in question, others have two or more alleles of the same gene. This can result in various […]

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Why Make A Humanized Mouse?

Why Make a Humanized Mouse?

Humanized Mouse Models The mouse has been used for over 30 years as a model system for studying human disease. Recently, “humanized” mice have grown in popularity because they are formidable models of the human being and therefore extremely useful for understanding the human condition. What exactly is a humanized mouse? A humanized mouse is […]

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Cre-Lox Facts

cre-lox

6 Facts You May Not Know About Cre-Lox The basics of conditional knockout mice are familiar to any researcher who uses mouse models, even if this model type isn’t yet a part of your research. Using the Cre-lox system in an experiment seems simple: two lines are crossed, one with tissue-specific expression of Cre and […]

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Floxing

Floxing: Flanking by loxP

What Is Gene Floxing and Why Is It Used so Frequently by Scientists Today? Floxing, or flanking by loxP, is a process used by geneticists by which a specifically targeted gene is flanked by two loxP sites. Although seemingly simple, this process is relatively new and quite complex. In most cases, gene targeting with the […]

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What Is A Conditional Allele?

What Is A Conditional Allele by INGENIOUS

Understanding Animal Model Options and Uses of Alleles in Genetic Research – What Is a Conditional Allele? Genetically modified animals are the cornerstone of research programs across many fields of study. When choosing a mouse model in particular, one option that should be thoroughly evaluated is a conditional allele. What is a conditional allele and […]

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What Is A Point Mutation?

What Is A Point Mutation

What Is A Point Mutation And Why Is It Important To Researchers? Questions such as “What is a point mutation and how is it relevant when it comes to gene editing?” are at the core of genetic research. Knowing this is extremely important for a clear understanding of mutations. Point mutations are typically known to […]

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Press Release: Ingenious Targeting Laboratory, Inc. Receives NIH Grant to Generate Exclusive COVID-19 ACE2 Mouse Models

COVID-19 Mouse Model NIH Grant

Funding from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) titled, “Humanization of ACE2 and Associated Priming Proteases in New Mouse Models for Downstream Disease and Therapy Investigations of COVID-19” Ronkonkoma, NY; January 4, 2021: ingenious targeting laboratory announced today that it has received a federal grant […]

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New Design Guide For Cre-lox Conditional Knockout Mouse Models

New Cre-Lox Design Guide For Conditional Knockout Mouse Models

How to choose the right strategy for your cKO model We’ve compiled a short guide to choosing a strategy for your next Cre-lox conditional knockout (cKO) model which you can download here. Compared with standard knockout models a cKO has much greater flexibility, for example by enabling tissue-specific knockout of your target gene. As with […]

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Why Should You Consider Making Transgenic Mice For Your Experiments?

Why should you consider making transgenic mice?

A Custom Transgenic Mouse Can Fit Your Research Goals Transgenic mice are genetically modified animals with an extra genetic sequence, called a transgene, permanently integrated into their genome. Making transgenic mice is a popular option for researchers because the sequence of the transgene is under the researcher’s control. With this flexibility different transgenic mice can […]

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