Add your starting alleles, define your target genotypes, and generate an optimized breeding plan. The tool calculates expected offspring ratios, identifies optimal cross sequences, and estimates timeline to study ready cohorts.
Planning multi allele breeding schemes can be complex. This tool simplifies the process by automating Mendelian genetics calculations and identifying optimal breeding strategies.
Enter each allele you need to combine in your final model. Include knockouts, Cre drivers, reporters, or humanized alleles. Specify starting genotypes and chromosomal locations if known to help identify potential linkage issues.
Define the experimental and control genotypes you need for your study. Specify how many mice of each genotype are required and any sex requirements. The tool accounts for Mendelian ratios when calculating breeding numbers.
The algorithm calculates the optimal sequence of crosses, identifies when to fix alleles to homozygosity, and maps the path from your starting strains to study ready cohorts. View expected offspring ratios at each generation.
Save your breeding plan as a PDF, share with collaborators, or request a consultation with our scientific team. We can help optimize your strategy, recommend Cre driver lines, or design custom models for your research.
See your entire breeding strategy mapped out generation by generation. Understand which crosses to prioritize and when you can expect to have experimental cohorts ready.
Calculate the number of breeding pairs and total mice needed to achieve your target sample sizes. Plan cage requirements and budget before starting.
The tool warns about embryonic lethal genotype combinations, germline Cre activity issues, and potential linkage problems that could complicate your breeding scheme.
Use the breeding scheme architect before ordering custom models to understand post delivery breeding requirements and timeline to study ready cohorts.
Our scientific consultants are available to discuss your breeding strategy and help design the optimal mouse model for your experimental goals.
Learn more about breeding strategies and model design
Understanding Cre recombinase and LoxP sites for conditional gene targeting
Choose the right knockout strategy for your research goals
Professional breeding services to accelerate your project timeline
Discuss your project with our scientific team