Metabolic Disease Mouse Models
Since 1998, ingenious targeting laboratory has supported metabolic disease researchers with mouse model generation contributing to peer reviewed publications in Diabetes, Cell Metabolism, Nature Medicine, and leading metabolism journals worldwide.
Our metabolic disease mouse models have advanced understanding of glucose homeostasis, lipid metabolism, and the pathophysiology of obesity related complications.
Metabolic Disease Categories
Diabetes Mouse Models
- Immune gene modifications for T1D
- Beta cell specific deletions
- Liver specific knockouts for hepatic glucose production
- Adipose specific knockouts for adipokine signaling
Obesity Mouse Models
- Leptin pathway modifications
- Adipocyte specific knockouts
- Hypothalamic gene deletions
- Brown adipose thermogenesis models
NASH and Liver Disease
- Hepatocyte specific knockouts
- Stellate cell modifications for fibrosis
- Kupffer cell knockouts for inflammation
- Diet induced models with genetic susceptibility
Metabolic Tissue Cre Drivers
Strain Background Considerations
C57BL/6J
Susceptible to diet induced obesity; Nnt mutation affects insulin secretion
C57BL/6N
Different metabolic profile; intact Nnt gene
BALB/c
Relatively resistant to diet induced obesity
129 strains
Variable metabolic phenotypes depending on substrain
Selected Publications
Nargis T, Muralidharan C, Enriquez JR, Wang JE, Kaylan K, Chakraborty A, Pratuangtham S, Figatner K, Nelson JB, May SC, Nadler JL, Boxer MB, Maloney, DJ, Tersey SA, Mirmira RG. (2024).
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice ↗JCI Insight 24(9): e185299
Ghosh A, Chénier I, Leung YH, Oppong AK, Peyot, M-L, Madiraju SRM, Al-Khairi I, Abubaker J, Al-Mulla F, Prentki M, Abu-Farha M. (2024).
Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice ↗iScience 12(27): 111292
Vacher CM, Lacaille H, O’Reilly JJ, Salzbank J, Bakalar D, Sebaoui S, Liere P, Clarkson-Paredes C, Sasaki T, Sathyanesan A, Kratimenos P, Ellegood J, Lerch JP, Imamura Y, Popratiloff A, Hashimoto-Torii K, Gallo V, Schumacher M, Penn AA. (2021).
Placental endocrine function shapes cerebellar development and social behavior ↗Nat Neurosci 24(10): 1392-1401
What Researchers Say
“The Hephaestin flox model ingenious has made for us has been great. It has helped generate eight research publications.”
— Joshua Dunaief, PhD, MD
University of Pennsylvania
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Metabolic Disease Research Insights
Expert research insights delivered biweekly. Written by PhD scientists, designed for researchers who need cutting-edge knowledge to advance their projects.