Cell Therapy Mouse Models

Common immunodeficient backgrounds include NSG (NOD-scid IL2Rγnull), NOG, and Rag2-/- IL2Rγ-/- mice. These backgrounds enable engraftment of human cells, tissues, or immune systems. Selection depends on whether you need complete immunodeficiency or specific immune component depletion.

Yes. Humanized immune system models can be created through engraftment of human hematopoietic stem cells, human peripheral blood mononuclear cells (PBMC), or human thymus and liver tissues. These models enable testing of cell therapies in context of human immune responses.

Tracking can be achieved through reporter knockins (fluorescent proteins, luciferase), genetic barcoding, or surface marker expression. Conditional transgenic systems can label specific cell populations. Reporter expression enables longitudinal tracking of engrafted cells through imaging or flow cytometry.

Yes. Cell therapy models can be combined with disease models (conditional knockouts, point mutations) to create permissive niches for cell engraftment or to study cell therapy function in disease context. For example, conditional deletion of endogenous cell populations can create space for transplanted cells.