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Knockin Rat Models

Since 1998, ingenious targeting laboratory has completed over 2,500 custom mouse and rat models, enabling precise insertion of human disease mutations, reporter genes, and functional variants in rodents providing superior translational relevance.

Knockin rats enable introduction of disease associated human variants within intact rat genomic context, permitting investigation of pathogenic mechanisms with greater translational fidelity than humanized mouse models. The combination of superior behavioral capacity, complex physiology, and precise genetic modifications makes knockin rats optimal for human disease modeling studies requiring maximal biological relevance.

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2,500+
Projects Completed
800+
Publications
26+
Years Experience
100%
Success Rate
✦ New for 2026

Breeding Scheme Architect

Plan complex multi-allele breeding strategies, calculate expected genotype ratios, and estimate time to experimental cohorts—all before starting your project.

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Visualize multi-generation breeding paths
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Calculate Mendelian ratios automatically
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Estimate timeline to study ready cohorts
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Free Research Tool

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Allele 1Gene-flox (conditional)
Allele 2Cre-driver (tissue-specific)
TargetHomozygous knockout

→ 3 generations to target genotype

Trusted by Leading Researchers

“The rat knock-in model from ingenious was reliable, precise, and accelerated our immunology research significantly.”

— Carla Rothlin, Professor and Director of Center of Immunology

Yale University

Start your project today

Our scientific consultants are ready to discuss your research requirements and recommend the optimal approach for your program. Initial consultation is provided at no charge.

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Frequently asked questions

Yes, knockin mutations can be introduced flanked by LoxP sites to create conditional knockin alleles permitting temporal or tissue specific modification. This approach is particularly valuable for studying mutations causing embryonic lethality or developmental toxicity when constitutive expression is problematic.

Humanized rats more closely approximate human physiology and behavior, with superior translational relevance particularly for diseases with behavioral components or cardiovascular manifestations. Transgenic mice with human transgene insertions remain valuable for high-throughput screening, while humanized knockin rats excel for detailed mechanistic investigation and drug development.

Yes, backcrossing knockin founders to wild type animals to establish F1 heterozygous generation enables rapid phenotype validation. Subsequent crosses generating F2 homozygous animals reveal genotype phenotype relationships.

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