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Knockout Rat Models

Since 1998, ingenious targeting laboratory has completed over 2,500 gene targeting projects across multiple species, including rat, enabling loss of function studies in larger rodents offering superior behavioral characterization and physiological readout capacity.

Knockout rat models provide distinct advantages for studies examining behavioral responses, cardiovascular physiology, renal function, and complex neurobiological phenomena where rodent size or documented behavioral capacity offers superior scientific value compared to mouse models. The trade off between increased project timeline and cost against superior phenotypic readouts makes knockout rats optimal for specific research questions despite greater complexity.

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2,500+
Projects Completed
800+
Publications
26+
Years Experience
100%
Success Rate
✦ New for 2026

Breeding Scheme Architect

Plan complex multi-allele breeding strategies, calculate expected genotype ratios, and estimate time to experimental cohorts—all before starting your project.

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Visualize multi-generation breeding paths
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Calculate Mendelian ratios automatically
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Estimate timeline to study ready cohorts
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Free Research Tool

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Allele 1Gene-flox (conditional)
Allele 2Cre-driver (tissue-specific)
TargetHomozygous knockout

→ 3 generations to target genotype

Trusted by Leading Researchers

“The rat knock-in model from ingenious was reliable, precise, and accelerated our immunology research significantly.”

— Carla Rothlin, Professor and Director of Center of Immunology

Yale University

Start your project today

Our scientific consultants are ready to discuss your research requirements and recommend the optimal approach for your program. Initial consultation is provided at no charge.

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Frequently asked questions

Yes, multiple mutations in several genes are feasible in rats, though knockout efficiency typically decreases with increased target number.

Morris water maze, open field tests, elevated plus maze, and novel object recognition effectively characterize behavioral phenotypes in knockout rats. More complex learning paradigms including 5 choice serial reaction time and operant conditioning reveal subtle cognitive changes invisible in simpler behavioral assays.

Yes, rat body size and commercial telemetry system availability make cardiovascular telemetry studies highly practical. Implanted transmitters enable continuous blood pressure, heart rate, and ECG monitoring throughout lifespan, revealing phenotypes impossible to detect in mice.

Lab Signals

Monitor Your Knockout Rat Project

Stay updated on your rat knockout model development with notifications on germline transmission, genotype confirmation, and behavioral characterization progress.

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