Metabolic Disease Mouse Models
Since 1998, ingenious targeting laboratory has supported metabolic disease researchers with custom mouse models contributing to peer reviewed publications in Diabetes, Cell Metabolism, Nature Medicine, and leading metabolism journals worldwide.
Our metabolic disease mouse models have advanced understanding of glucose homeostasis, lipid metabolism, and the pathophysiology of obesity related complications.
Metabolic Disease Categories
Diabetes Mouse Models
- Immune gene modifications for T1D
- Beta cell specific deletions
- Liver specific knockouts for hepatic glucose production
- Adipose specific knockouts for adipokine signaling
Obesity Mouse Models
- Leptin pathway modifications
- Adipocyte specific knockouts
- Hypothalamic gene deletions
- Brown adipose thermogenesis models
NASH and Liver Disease
- Hepatocyte specific knockouts
- Stellate cell modifications for fibrosis
- Kupffer cell knockouts for inflammation
- Diet induced models with genetic susceptibility
Metabolic Tissue Cre Drivers
Strain Background Considerations
C57BL/6J
Susceptible to diet induced obesity; Nnt mutation affects insulin secretion
C57BL/6N
Different metabolic profile; intact Nnt gene
BALB/c
Relatively resistant to diet induced obesity
129 strains
Variable metabolic phenotypes depending on substrain
Selected Publications
Turner MB et al. (2025).
Adipocyte specific deletion of the mineralocorticoid receptor improves glucose homeostasis. ↗Diabetes, Obesity and Metabolism 27(5): 2341-2355
Philippe MA et al. (2025).
BMAL2 controls adipose tissue inflammation and metabolic adaptation during obesity. ↗Metabolism 174: 156396
Vacher CM et al. (2021).
Placental endocrine function shapes cerebellar development and social behavior. ↗Nature Neuroscience 24(10): 1392-1401
What Researchers Say
“The Hephaestin flox model ingenious has made for us has been great. It has helped generate eight research publications.”
— Joshua Dunaief, PhD, MD
University of Pennsylvania
Start Your Metabolic Disease Model Project
Our scientific consultants are ready to discuss your metabolic research requirements and recommend the optimal model design for your program.
Frequently asked questions
Metabolic Disease Research Insights
Expert research insights delivered biweekly. Written by PhD scientists, designed for researchers who need cutting-edge knowledge to advance their projects.