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Mouse Model Strategies & Allele Types

Conventional (Constitutive) Knockout Mouse Models

A genetically engineered mouse in which a target gene is permanently deleted or disrupted in every cell of the body from the earliest stages of development. This classical approach provides foundational insight into gene function.

Overview

Before conditional and inducible systems were developed, the conventional knockout was the primary strategy for studying gene function—and it remains one of the most powerful tools in modern genetics. By completely inactivating a specific gene across all tissues, researchers can observe the full range of biological consequences.

Frequently Asked Questions

When is a conventional knockout better than a conditional knockout?

Conventional knockouts are ideal for understanding fundamental gene functions and modeling diseases caused by complete gene loss. Conditional approaches are better when the gene is essential or has tissue-specific effects.

Can a conventional knockout model be converted into a conditional one?

No. Conventional knockouts involve permanent gene deletion. Conditional knockouts must be designed with site-specific recombination elements, such as LoxP sites, from the start.

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Related Terms

Knockout (KO) Mouse Models

A genetically engineered mouse in which a specific gene has been permanently inactivated ('knocked out') to study its biological function, role in disease, and potential as a therapeutic target.

Conditional Knockout (cKO) Mouse Models

A genetically engineered mouse in which a specific gene can be selectively inactivated in chosen tissues, cell types, or developmental stages—enabling precise studies of gene function while avoiding embryonic lethality or systemic effects.

More in Mouse Model Strategies & Allele Types

Knockout (KO) Mouse ModelsConditional Knockout (cKO) Mouse ModelsKnockin (KI) Mouse ModelsHumanized Mouse ModelsReporter Gene / Reporter Allele
Conditional Knockout (cKO) Mouse ModelsView All TermsCre Driver Line (Tissue-Specific Cre)

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