Over 26 years of pioneering mouse genetics expertise, guiding thousands of researchers from project design through publication
Since 1998, ingenious targeting laboratory has maintained unwavering commitment to scientific rigor, experimental reproducibility, and researcher success. Every mouse model we generate undergoes comprehensive quality control to ensure stable germline transmission and phenotypic consistency.
Our team combines decades of mouse genetics experience with continuous innovation. We have contributed to over 800 peer-reviewed publications across Nature, Science, Cell, and leading disease-specific journals, advancing understanding of human disease mechanisms and therapeutic interventions.
Every project receives dedicated scientific oversight from design through delivery. Our quality control protocols ensure: verified germline transmission, confirmed allele structure, complete molecular characterization, and detailed breeding recommendations for reproducible cohort generation.
Homologous recombination expertise spanning conventional knockouts, conditional alleles, point mutations, and complex humanization strategies. Over 2,500 successful targeting events since 1998.
Critical exon selection, LoxP site placement optimization, selection cassette design, and germline stability prediction. Every design reviewed for experimental utility and phenotypic impact.
Comprehensive understanding of tissue-specific Cre drivers, inducible systems, and conditional deletion strategies. Expert guidance on Cre line selection and breeding scheme optimization.
Southern blot confirmation, PCR genotyping design, expression analysis, and multi-generation breeding verification. All founders guaranteed for stable germline transmission.
Strain selection consultation, backcrossing strategy design, speed congenic implementation, and phenotype-background interaction analysis. Expertise across C57BL/6, 129, BALB/c, and other backgrounds.
Research application consultation, phenotyping strategy development, control selection guidance, and statistical power analysis. Partnership approach to ensure model utility for specific research questions.
Peer-Reviewed Publications
Mouse Models Generated
Years of Excellence
NIH Award Recipient
Our mouse models have enabled breakthrough discoveries across diverse therapeutic areas:
Initial consultation to understand research goals, phenotype expectations, and experimental timeline. Allele design strategy review ensuring optimal exon selection, LoxP placement, and control strategies.
Sequence verification of all vector components including homology arms, selection cassettes, and recombination sites. Confirmation of proper reading frame and domain preservation for conditional alleles.
Southern blot confirmation of correct integration, PCR verification of allele structure, and karyotype analysis ensuring chromosomal stability. Only properly targeted clones advance to injection.
Germline transmission verification through breeding analysis, genotyping confirmation across multiple generations, and expression analysis where applicable. Delivery only after confirmed stable germline.
Ongoing consultation for breeding questions, genotyping troubleshooting, phenotype optimization, and experimental design. Lifetime technical support for all delivered models.
Our scientific team is ready to help design your custom mouse model. Get expert guidance from initial consultation through germline transmission.