Explore Therapeutic Areas
Custom mouse models for research across major disease categories, supporting both basic research and therapeutic development programs.
Oncology Mouse Models
Cancer research requires models that accurately recapitulate tumor biology, immune interactions, and therapeutic responses. ingenious targeting laboratory supports oncology programs with tumor suppressor knockouts, oncogene models, and humanized immune checkpoint mice for immuno oncology studies.
Key Applications
- Tumor suppressor knockout models enable study of cancer initiation and progression
- Conditional approaches allow tissue specific or temporal control over tumor development
- Germline knockouts model inherited cancer syndromes
- Humanized checkpoint models including PD1, PDL1, CTLA4, LAG3, and TIM3 for immuno oncology
Neuroscience Mouse Models
Neurological and neurodegenerative disease research demands models that reproduce disease pathology while enabling mechanistic studies. ingenious targeting laboratory has generated models for Alzheimer disease, Parkinson disease, ALS, Huntington disease, epilepsy, autism spectrum disorders, and other neurological conditions.
Key Applications
- Alzheimer disease models incorporate mutations in APP, presenilin genes, or tau
- Movement disorder research uses alpha synuclein models for Parkinson disease
- SOD1 or TDP43 models for ALS and huntingtin models for Huntington disease
- Reporter knockins enable cell population tracking in neural circuits
Metabolic Disease Mouse Models
Metabolic research spans diabetes, obesity, fatty liver disease, and lipid metabolism disorders. ingenious targeting laboratory provides models for studying metabolic pathways, testing therapeutic interventions, and understanding disease progression.
Key Applications
- Diabetes models address type 1 autoimmune mechanisms and type 2 insulin resistance
- Tissue specific knockouts in liver, adipose, muscle, or pancreas reveal organ contributions
- NASH and obesity research with models developing hepatic steatosis and fibrosis
- Humanized models enable testing of human specific therapeutic targets
Immunology Mouse Models
Immune system research requires models that accurately reflect human immunology while enabling mechanistic studies. ingenious targeting laboratory supports autoimmune disease research, inflammatory conditions, and basic immunology with knockout, knockin, and humanized models.
Key Applications
- Autoimmune disease models for rheumatoid arthritis, lupus, and multiple sclerosis
- Inflammatory bowel disease and other inflammatory conditions
- Conditional knockouts in specific immune cell populations
- Humanized immune models express human cytokines, receptors, or immune checkpoints
Cardiovascular Mouse Models
Cardiovascular research encompasses atherosclerosis, heart failure, hypertension, cardiac fibrosis, and vascular disease. ingenious targeting laboratory provides models for studying cardiovascular pathophysiology and testing therapeutic approaches.
Key Applications
- Atherosclerosis models combine lipid metabolism gene modifications with ApoE or LDLR deficiency
- Conditional knockouts enable tissue specific studies in endothelium or smooth muscle
- Cardiac disease models address heart failure, arrhythmia, and fibrosis
- Ion channels, sarcomeric proteins, or signaling pathway component modifications
Rare Disease Mouse Models
Rare and orphan diseases affect small patient populations but often have high unmet need for effective therapies. ingenious targeting laboratory supports rare disease research with models for muscular dystrophies, lysosomal storage disorders, cystic fibrosis, and other inherited conditions.
Key Applications
- Muscular dystrophy models carry mutations in dystrophin, dysferlin, or other muscle proteins
- Enable study of disease mechanisms and testing of gene therapy approaches
- Lysosomal storage disorder models reproduce enzyme deficiencies
- Platforms for enzyme replacement and gene therapy development
Ophthalmology Mouse Models
Vision research addresses retinal degenerations, glaucoma, macular degeneration, and other ocular conditions. ingenious targeting laboratory provides models for studying photoreceptor biology, retinal pigment epithelium function, and visual pathway development.
Key Applications
- Retinal degeneration models carry mutations in rhodopsin, peripherin, or other photoreceptor genes
- Conditional approaches enable temporal control over degeneration onset
- Reporter knockins enable visualization of specific retinal cell populations
- Tracking of cell fate during development and disease
What Researchers Say
“The Hephaestin flox model ingenious has made for us has been great. It has helped generate eight research publications.”
— Joshua Dunaief, PhD, MD
University of Pennsylvania
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