Our Custom Approach
Scientific Consultation
Every custom project begins with in depth scientific consultation. Our team works with you to understand your research questions, experimental design, and specific requirements.
- Discussion of research objectives and experimental approach
- Review of gene structure and available allele designs
- Evaluation of potential complications or challenges
- Recommendations for optimal strategy
Tailored Allele Design
We design alleles specifically optimized for your experimental needs, drawing on our extensive experience with gene targeting strategies.
- Custom targeting vector design
- Selection of appropriate genetic elements
- Consideration of downstream applications
- Flexibility for future experiments
Project Types
Conventional Knockout
Complete gene inactivation throughout the organism.
- Global gene deletion
- Simple allele design
- Streamlined approach
- Lower cost
Conditional Knockout
Cre lox controlled gene deletion for tissue and temporal specificity.
- Floxed allele design
- Tissue specific deletion
- Temporal control options
- Maximum flexibility
Knockin
Introduction of specific sequences, mutations, or reporter genes.
- Point mutations
- Reporter insertions
- Human gene replacement
- Tag insertions
Humanization
Replacement of mouse genes with human sequences.
- Single exon to full gene
- Functional validation
- Disease modeling
- Drug target studies
Complex Projects
Multi allele designs, large insertions, and specialized applications.
- BAC transgenesis
- Multiple modifications
- Dual recombinase systems
- Custom requirements
Published Research
Here are some custom mouse model publications for your review.
What Researchers Say
“I've been working with iTL over the past 5 years in the production of 3 different genetically altered mice. Not only did iTL help in the design of the mice, but the entire process was transparent with the opportunity at any time along the way to discuss my questions or concerns with scientists who had significant insight into the process. The mice were delivered on time, as billed!”
— Raghu Mirmira, MD, PhD
University of Chicago
Start Your Custom Project
Contact us to discuss your custom mouse model requirements. Our scientific team will work with you to design the optimal approach for your research.