IBD Mouse Models
Since 1998, ingenious targeting laboratory has supported inflammatory bowel disease research with custom mouse models enabling mechanistic studies of intestinal inflammation, mucosal immunity, and therapeutic interventions for Crohn disease and ulcerative colitis.
IBD mouse models provide essential platforms for investigating the molecular pathways underlying chronic intestinal inflammation and developing therapies for millions of patients affected by these conditions.
Spontaneous IBD Models
IL10 Knockout
Develops spontaneous colitis dependent on intestinal microbiota. Shows importance of regulatory cytokines.
IL2 Knockout
Autoimmune colitis with ulcerative colitis like features.
NOD2 Knockout/Knockin
Crohn disease associated gene. Patient derived variants model Crohn susceptibility.
ATG16L1 Hypomorph
Reduced ATG16L1 causes Paneth cell abnormalities resembling Crohn disease.
Induced Colitis Models
DSS (Dextran Sulfate Sodium)
Oral DSS damages epithelial barrier, causing acute colitis. Cycles produce chronic colitis.
TNBS
Rectal administration causes transmural inflammation resembling Crohn disease.
Oxazolone
Produces Th2 mediated colitis resembling ulcerative colitis.
CD45RBhigh T Cell Transfer
Transfer of naive CD4+ T cells causes chronic colitis. Models T cell mediated inflammation.
Cre Drivers for IBD Studies
Phenotyping IBD Models
Clinical Assessment
- Body weight loss
- Stool consistency
- Occult blood
- Disease activity index
Histological Assessment
- H&E staining
- Inflammation scoring
- Crypt damage
- Ulceration
Molecular Assessment
- Cytokine expression (TNF, IL1B, IL6)
- Barrier function (FITC dextran)
- Microbiome analysis (16S sequencing)
What Researchers Say
“I've been working with iTL over the past 5 years in the production of 3 different genetically altered mice. Not only did iTL help in the design of the mice, but the entire process was transparent with the opportunity at any time along the way to discuss my questions or concerns with scientists who had significant insight into the process. The mice were delivered on time, as billed!”
— Raghu Mirmira, MD, PhD
University of Chicago
Start Your IBD Model Project
Our scientific consultants can help design custom IBD models tailored to your research questions, whether studying barrier function, immune cell contributions, or therapeutic interventions.
Frequently asked questions
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