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Mouse Model Strategies & Allele Types

Rosa26 Locus

A well-characterized safe harbor site in the mouse genome, located on chromosome 6. It supports stable and ubiquitous expression of inserted genes without interfering with nearby genomic functions and is the standard integration site for transgenic constructs.

Overview

The Rosa26 locus is a well-characterized safe harbor site in the mouse genome, located on chromosome 6. It supports stable and ubiquitous expression of inserted genes without interfering with nearby genomic functions and has become the standard integration site for transgenic and conditional constructs.

Frequently Asked Questions

Why is Rosa26 the most commonly used safe harbor?

Rosa26 offers open chromatin structure, ubiquitous expression across tissues, and genomic neutrality—making it ideal for reporter constructs, Cre-inducible alleles, and human gene integrations.

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Related Terms

Safe Harbor Locus

A defined region of the genome where a transgene or targeted DNA sequence can be inserted without disrupting endogenous genes or regulatory networks. Integration at a safe harbor site allows stable, predictable expression.

Reporter Gene / Reporter Allele

A reporter gene is an easily detectable genetic marker—such as GFP, LacZ, or luciferase—inserted into a mouse genome to visualize gene expression, monitor cellular activity, or trace lineage in vivo.

Safe-Harbor Targeted Transgenesis

A precise genome engineering strategy in which a transgene is inserted into a well-characterized, transcriptionally active, and non-disruptive genomic locus to ensure predictable and stable expression.

More in Mouse Model Strategies & Allele Types

Knockout (KO) Mouse ModelsConditional Knockout (cKO) Mouse ModelsConventional (Constitutive) Knockout Mouse ModelsKnockin (KI) Mouse ModelsHumanized Mouse Models
Rosa26View All TermsSafe Harbor Locus

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