Syngeneic Mouse Models
Since 1998, ingenious targeting laboratory has supported immuno oncology research with custom mouse models that enable syngeneic tumor studies, providing immunocompetent platforms for evaluating cancer immunotherapies, checkpoint inhibitors, and combination treatment strategies.
Syngeneic tumor models involve implanting tumor cell lines into genetically compatible mouse hosts, enabling study of tumor immunity in the context of a fully functional immune system.
Key Advantages of Syngeneic Models
Intact Immune System
Unlike xenograft models, syngeneic models have functional T cells, B cells, NK cells, and myeloid populations.
Tumor Microenvironment
Immune infiltration and tumor immune interactions can be studied in physiological context.
Immunotherapy Testing
Essential for checkpoint inhibitors and other immunotherapies that require functional immunity.
Rapid Tumor Growth
Established cell lines produce consistent, reproducible tumors for study.
Common Syngeneic Tumor Lines
C57BL/6 Compatible Lines
BALB/c Compatible Lines
Humanized Checkpoint Models for Syngeneic Studies
PD1 Humanized
Testing anti human PD1 antibodies (pembrolizumab, nivolumab)
PDL1 Humanized
Testing anti PDL1 antibodies (atezolizumab, durvalumab)
CTLA4 Humanized
Testing anti CTLA4 antibodies (ipilimumab)
Dual PD1/CTLA4
Combination checkpoint blockade studies
What Researchers Say
“iTL produced a new conditional mouse model for us and the quality of service was exceptional. The team is extremely knowledgeable and the work was completed at the highest possible standards. My project manager was excellent and always happy to answer technical questions and keep me up to date with progress and potential problems. I would recommend iTL highly and will use them again in the future if I need to generate a new mouse line.”
— Albert Basson, PhD
King's College London
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Our scientific consultants can help you select the optimal syngeneic models and humanized checkpoint combinations for your immuno oncology program.
Frequently asked questions
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