Cdk5 Conditional Knockout mouse — Villin-CreERT2 pairing
Conditional deletion of Cdk5 limits genetic change to the lineage you choose. That precision matters for oncology, immunology, and metabolic work where systemic loss would confound interpretation. After you confirm your Cre specificity, crossing to Cdk5 floxed stock yields interpretable cohorts. For intestinal work, plan Cre specificity, reporter crosses, and baseline phenotyping before you scale.
Driver pairing
Villin-CreERT2 biases toward intestinal. Inducible: yes (tamoxifen).
Catalog options
Conditional knockout keeps intestine as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
| Model | Type | Category | Availability | Catalog # | |
|---|---|---|---|---|---|
| Cdk5-Flox | Conditional Knockout | KO/CKO mice | sperm cryopreservation | CKO 220575 | Inquire |
Why this approach
Conditional knockout keeps neuron as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Cdk5 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Cdk5 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with milestones for genotyping, QC, and dispatch.
FAQ
Is Cdk5 knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Cdk5 germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for villin creert2 focused experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. Your query highlights villin creert2 as a primary axis, which we treat as the starting point for driver selection.
Do you ship live Cdk5 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a model generation project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Cdk5?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.