Researcher Spotlight
Scientists whose published work used ITL custom mouse models. Each feature documents the research question, the model strategy, and what the work reveals.
A Lysosomal Brake That Sustains Anti-Tumor Immunity
Inside the Billadeau lab at Mayo Clinic, where a knockout mouse reveals how lysosomal NKG7 restrains mTORC1 to preserve CD8 T cell durability and the capacity to control tumors over time.
Read SpotlightThe Splicing Factor That Safeguards the T Cell
How a T cell specific deletion of CLNS1A reveals a previously unrecognized control point for genome stability, cell cycle progression, and the boundary between healthy immunity and autoimmunity.
Read SpotlightA Single Variant That Delays the Inevitable
Inside the Yamamoto lab's arc from a Venezuelan pedigree to a shared therapeutic target across Huntington's, Parkinson's, and tauopathies, and the point mutation knockin that recapitulated 23 years of protection in a mouse.
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