Adora2a Mouse Models

Why Model Adora2a

Adora2a is the mouse ortholog of human ADORA2A and encodes the adenosine A2A receptor, a class A G-protein-coupled receptor. A2A-receptor signaling has been associated with regulation of immune-cell activity and with neurological functions in the basal ganglia.

A2A-receptor antagonists are used in Parkinson’s disease and are under study in cancer immunotherapy, where adenosine signaling can dampen immune responses. Adora2a-deficient mice are viable and show altered responses to adenosine and changes in motor and inflammatory phenotypes.

Model Applications

Humanized ADORA2A models, in which the human receptor replaces the mouse counterpart, have been used to evaluate A2A-receptor-targeted agents in defined experimental settings.

Custom Adora2a Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Comparative efficacy and safety of adenosine A2A receptor antagonists for Parkinson’s disease: a systematic review and network meta-analysis. Brain Netw Disord. 2026. doi:10.1016/j.bnd.2026.03.001
• Meng F et al. Cloning and expression of the A2a adenosine receptor from guinea pig brain. Neurochem Res. 1994. doi:10.1007/bf00971338

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Adora1 · Adora2b · Adora3 · Drd2