ALB Mouse Models

Why Model ALB

Alb is the mouse ortholog of human ALB and encodes serum albumin, the most abundant protein in blood plasma, produced by the liver. Albumin has been associated with maintenance of plasma oncotic pressure and with transport of many endogenous and exogenous molecules.

Albumin’s long circulating half-life is used in drug design to extend the half-life of therapeutics, and albumin is used clinically as a volume expander. Alb-deficient mice are viable with altered plasma protein handling.

Model Applications

Humanized ALB models, in which the human protein replaces the mouse counterpart, have been used to study the pharmacokinetics of albumin-binding and albumin-fused therapeutics in defined experimental settings.

Custom ALB Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Revolutionizing Alzheimer’s treatment: harnessing human serum albumin for targeted drug delivery and therapy advancements. Ageing Res Rev. 2024. doi:10.1016/j.arr.2024.102379
• Dugaiczyk A et al. Nucleotide sequence and the encoded amino acids of human serum albumin mRNA. Proc Natl Acad Sci U S A. 1982. doi:10.1073/pnas.79.1.71

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Afp · Gc · Ttr · Serpina1a