ANGPT2 Mouse Models

Why Model ANGPT2

Angpt2 is the mouse ortholog of human ANGPT2 and encodes angiopoietin-2, a secreted ligand of the endothelial receptor Tie2. Angiopoietin-2 has been associated with context-dependent regulation of blood-vessel stability and angiogenesis.

Angiopoietin-2 has been associated with tumor angiogenesis, retinal vascular disease, and vascular leak, and ANGPT2-directed approaches, including in combination with VEGF inhibition, are in use or under study. Angpt2-deficient mice show lymphatic and vascular defects.

Model Applications

Humanized ANGPT2 models, in which the human protein replaces the mouse counterpart, have been used to evaluate angiopoietin-2-directed agents in defined experimental settings.

Custom ANGPT2 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• The correlation between serum angiopoietin-2 levels and acute kidney injury (AKI): a meta-analysis. Clin Chem Lab Med. 2024. doi:10.1515/cclm-2024-0365
• Maisonpierre PC et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science. 1997. doi:10.1126/science.277.5322.55

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Angpt1 · Tek · Vegfa · Tie1