CCR8 Mouse Models

Why Model CCR8

Ccr8 is the mouse ortholog of human CCR8 and encodes CC chemokine receptor 8, a class A G-protein-coupled receptor. CCR8 is expressed on certain regulatory T cells and other cells and has been associated with their migration and tissue localization.

CCR8 is expressed on tumor-infiltrating regulatory T cells, and CCR8-directed agents are under study for selective depletion of these cells in cancer. Ccr8-deficient mice are viable with altered type 2 and regulatory T-cell responses in some models.

Model Applications

Humanized CCR8 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate CCR8-directed antibodies intended to target tumor-infiltrating regulatory T cells in defined experimental settings.

Custom CCR8 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• CCR8: a promising therapeutic target against tumor-infiltrating regulatory T cells. Trends Immunol. 2025. doi:10.1016/j.it.2025.01.001
• Tiffany HL et al. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. J Exp Med. 1997. doi:10.1084/jem.186.1.165

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Ccl1 · Ccr4 · Foxp3 · Ccr10