CD2 Mouse Models

Why Model CD2

Cd2 is the mouse ortholog of human CD2 and encodes CD2 (LFA-2, T11), an immunoglobulin-superfamily adhesion receptor on T cells and natural killer cells. CD2 binds CD58 (or CD48 in mice) and has been associated with cell adhesion and costimulation of T-cell activation.

CD2 is a target of agents used in psoriasis and transplantation and has been studied in T-cell-directed therapy. Cd2-deficient mice are viable with altered T-cell responses in some settings.

Model Applications

Humanized CD2 models, in which the human protein replaces the mouse counterpart, have been used to evaluate CD2-directed agents in defined experimental settings.

Custom CD2 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2. Exp Mol Med. 2024. doi:10.1038/s12276-024-01317-9
• Sewell WA et al. Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen. Proc Natl Acad Sci U S A. 1986. doi:10.1073/pnas.83.22.8718

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cd58 · Cd48 · Cd2ap · Lck